[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646190":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":68,"collaborators":25,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":25,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":25,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Hospital Universitario Dr. Jose E. Gonzalez","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Participants assigned to this arm will receive one identical, inactive oral capsule daily for a period of 6 months.",[13],"Dietary Supplement: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Synbiotic","EXPERIMENTAL","Participants assigned to this arm will receive one oral capsule daily for a period of 6 months. Each capsule contains a combination of probiotic strains and prebiotic fibers.",[19],"Dietary Supplement: Synbiotic",[21,26],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Oral administration of an active nutritional supplement consisting of one capsule daily taken in the morning before meals for 6 months. Each capsule contains a specific synbiotic formulation composed of probiotic strains (Bifidobacterium longum, Lactobacillus acidophilus, and Streptococcus thermophilus at 7.5 x 10\\^12 CFU\u002F100g) combined with prebiotic soluble fibers (chicory inulin root and tapioca starch) designed to modulate the gut microbiota.",[15],null,{"type":22,"name":9,"description":27,"armGroupLabels":28,"otherNames":25},"Oral administration of one identical, inactive oral capsule daily taken in the morning before meals for a period of 6 months. The placebo capsule looks, tastes, and smells exactly like the intervention supplement but contains no active ingredients.",[9],[30],{"name":31,"affiliation":32,"role":33},"Elisa María Guadalupe Guerrero González, MD","Hospital Universitario. Dr. José Eleuterio González","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","528182803788","eguerrerog@uanl.edu.mx",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Giovanna Yazmín Arteaga Müller, MD, PhD","528112512168","giomuller@gmail.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Hospital Universitario Dr. José E. González, Centro Regional de Enfermedades Renales (CRER)","RECRUITING","Monterrey","Nuevo León","64460","Mexico","MX",{"type":53,"coordinates":54},"Point",[55,56],-100.31721,25.68435,{"lat":56,"lon":55},[59,63,67],{"name":60,"role":36,"phone":61,"phoneExt":25,"email":62},"Irma Isabel Flores Ponzio, MD","528127312940","Irmaflorespz24@gmail.com",{"name":64,"role":36,"phone":65,"phoneExt":25,"email":66},"Heidi Daniela Hernández Francisco, MD","528180259573","heididhf@gmail.com",{"name":31,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":33,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Irma Isabel Flores Ponzio","Clinical Research Fellow, Department of Nephrology","100646190","probiotic-and-prebiotic-supplementation-in-peritoneal-dialysis-patients-100646190",false,"NCT07694791","Probiotic and Prebiotic Supplementation in Peritoneal Dialysis Patients","Impact of Synbiotic Supplementation in Peritoneal Dialysis Patients","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Patients diagnosed with kidney disease who have been receiving peritoneal dialysis at home for at least 1 month.\n\nExclusion Criteria:\n\n* Patients who are unable to eat or receive food through a feeding tube.\n* Patients who have taken prebiotics or probiotics (supplements that support gut health) in the month before the study starts.\n* Patients who used antibiotics in the month before the study starts.\n* Patients who cannot attend the scheduled follow-up visits (missing the second follow-up appointment will result in being removed from the study).\n* Note on non-adherence and withdrawal: Patients who are unable to take their assigned capsules regularly (taking less than 80% of the total capsules will result in being removed from the study).","ALL","18 Years",{"count":81,"type":82},60,"ESTIMATED","INTERVENTIONAL",[85],"NA","The goal of this clinical trial is to learn if synbiotics work to lower inflammation in adults with chronic kidney disease who are on peritoneal dialysis. Synbiotics are daily capsules that contain a mix of probiotics (good bacteria) and prebiotics (fiber that feeds good bacteria).\n\nThe main questions it aims to answer are:\n\nDo synbiotics lower the level of inflammation markers in the blood? Do synbiotics improve the nutritional status of the participants? Do synbiotics lower the number of peritonitis (peritoneal infections) episodes?\n\nResearchers will compare synbiotics to a placebo to see if the treatment works. A placebo is a look-alike capsule that contains no active ingredients. Participants will:\n\nTake 1 capsule every day for 6 months Visit the clinic at the start, at 3 months, and at 6 months for blood tests and nutrition checkups",[88,89],"Chronic Kidney Disease (Stages 4 and 5)","Peritoneal Dialysis (PD)",[91,92,93,94,95,96],"Synbiotics","Probiotics","Prebiotics","Inflammation","Uremic Toxins","Dialysis","2026-07-04",{"date":99,"type":100},"2026-07-10","ACTUAL",{"date":102,"type":100},"2025-10-03",{"date":104,"type":82},"2027-06",{"name":5,"class":6},1]