[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658023":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":31,"studyPopulation":24,"armGroups":32,"interventions":45,"overallOfficials":24,"centralContacts":53,"locations":59,"responsibleParty":75,"collaborators":24,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":24,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":24,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":24,"overallStatus":61,"whyStopped":24,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Tanta University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":24},[9],{"measure":10,"description":11,"timeFrame":12},"Incidence of ventilator-associated pneumonia","Incidence of ventilator-associated pneumonia (VAP) diagnosed according to predefined CDC\u002FNHSN pediatric criteria","During the first 28 days after initiation of mechanical ventilation",[14,18,21],{"measure":15,"description":16,"timeFrame":17},"Duration of mechanical ventilation","Duration of invasive mechanical ventilation will be measured in days from initiation of mechanical ventilation until successful extubation.","Up to 28 days",{"measure":19,"description":20,"timeFrame":17},"Pediatric intensive care unit length of stay","Pediatric intensive care unit (PICU) length of stay will be measured in days from PICU admission until PICU discharge.",{"measure":22,"description":23,"timeFrame":17},"Incidence of mortality","Incidence of mortality will be recorded.",null,{"allocation":26,"interventionModel":27,"interventionModelDescription":24,"primaryPurpose":28,"observationalModel":24,"timePerspective":24,"maskingInfo":29},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":30,"maskingDescription":24,"whoMasked":24},"NONE","Critically ill children are the children whom requiring, or potentially requiring, high reliance or serious consideration whether in medical, surgical or trauma-related fields.\n\nBased on the time of onset of Ventilator Associated Pneumonia (VAP), it can be divided into two types. Early-onset VAP occurs during the first four days of mechanical ventilation and is usually caused by antibiotic sensitive bacteria. Late-onset VAP develops five or more days after initiation of MV and is caused by multidrug-resistant (MDR) pathogens .VAP is associated with a high rate of all-cause mortality and a prolonged duration of mechanical ventilation and intensive care unit stay.",[33,39],{"label":34,"type":35,"description":36,"interventionNames":37},"Group I","EXPERIMENTAL","Critically ill ventilated children will receive standard management plus probiotics.",[38],"Drug: Probiotics",{"label":40,"type":41,"description":42,"interventionNames":43},"Group II","ACTIVE_COMPARATOR","Critically ill ventilated children will receive standard management only.",[44],"Other: Standard management",[46,50],{"type":47,"name":48,"description":36,"armGroupLabels":49,"otherNames":24},"DRUG","Probiotics",[34],{"type":6,"name":51,"description":42,"armGroupLabels":52,"otherNames":24},"Standard management",[40],[54],{"name":55,"role":56,"phone":57,"phoneExt":24,"email":58},"Yomna G El-Feky, MD","CONTACT","00201005562005","Youmna.elfeky@med.tanta.edu.eg",[60],{"facility":5,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"RECRUITING","Tanta","Al Gharbia","31739","Egypt","EG",{"type":68,"coordinates":69},"Point",[70,71],31.00192,30.78847,{"lat":71,"lon":70},[74],{"name":55,"role":56,"phone":57,"phoneExt":24,"email":58},{"type":76,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Yomna Gaber El-Feky","Lecturer of Pediatrics, Faculty of Medicine, Tanta University, Egypt.","100658023","probiotic-role-in-prevention-of-ventilator-associated-pneumonia-in-critically--ill-children-admitted-at-pediatric-intensive-care-unit-100658023",false,"NCT07848165","Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care Unit","Assessment of Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care Unit","Inclusion Criteria:\n\n* Critically ill children from 1 month to 18 years.\n* Both sexes.\n* Ventilated not due to chest infection.\n\nExclusion Criteria:\n\n* Children recently received enteral vaccines.\n* Children receiving chronic immunosuppressive such as chemotherapy agents. and immunosuppressive medications, and high dose corticosteroids (more than 1 milligram per kilogram).\n* Children with contraindications of enteral feeding.\n* Children with gastrointestinal bleeding.\n* Children with open wounds following major surgery.\n* Children with short gut syndrome.","ALL","1 Month","18 Years",{"count":90,"type":91},68,"ESTIMATED","INTERVENTIONAL",[94],"NA","The aim of the work is to evaluate the impact of Probiotics supplementation on prevention of ventilator associated pneumonia in critically ill children admitted at Pediatric Intensive Care Unit at Tanta University Hospitals.",[97,98,99],"Probiotic","Ventilator Associated Pneumonia","Critically- Ill Children","2026-09-26",{"date":102,"type":103},"2026-09-29","ACTUAL",{"date":105,"type":103},"2026-07-01",{"date":107,"type":91},"2027-02-01",{"name":5,"class":6},1]