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The WSG ADAPT trial data on the impact of postmenopausal status and\u002For use of OFS within 3-4 weeks endocrine induction therapy show relevant impact of OFS\u002Fpostmenopausal status on Ki-67 response; also, secondary amenorrhea after (neo-)adjuvant chemotherapy was a positive predictor of outcome due to OFS \\[8, 9\\].\n\nThis registry will give insights in the real-world use of OFS and the effect of secondary amenorrhea in female pre- and perimenopausal patients with or without previous use of chemotherapy and with different endocrine treatments (ET +\u002F- GnRH).\n\nAs adherence over time (5-10 years) plays a major role in the endocrine treatment, the registry will follow patients' treatments for up to 10 years and include QoL information.\n\nResults of MammaPrint® (MammaPrint® Index) as indicating factor for chemotherapy use and risk classification, thus, choice of adjuvant treatment (chemotherapy, OFS combined with endocrine therapy, or endocrine therapy alone) will be correlated to outcome under real-world conditions.\n\nBaseline, treatment, and relapse data shall be collected to gain further insight in the treatment paths, treatment adherence, and outcome of such patients.",[978],"Female Breast Cancer",[980,981,982,983,984,985,986,987],"HR+","HER2-","EBC","early breast cancer","female","OFS","ET","chemotherapy","2026-08-04",{"date":990,"type":991},"2026-08-05","ACTUAL",{"date":993,"type":991},"2022-12-07",{"date":995,"type":973},"2035-06",{"name":5,"class":6},71]