[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651448":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":46,"responsibleParty":106,"collaborators":26,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":110,"sex":116,"minAge":117,"maxAge":26,"enrollmentInfo":118,"targetDuration":26,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":127,"overallStatus":136,"whyStopped":26,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":146},{"fullName":5,"class":6},"Qilu Hospital of Shandong University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Prophylactic IABP + PPCI","EXPERIMENTAL","Participants randomized to this arm will receive prophylactic intra-aortic balloon pump counterpulsation before primary percutaneous coronary intervention (PPCI), followed by standard PPCI and guideline-directed medical therapy.",[13,14],"Device: Intra-Aortic Balloon Pump","Procedure: Primary Percutaneous Coronary Intervention",{"label":16,"type":17,"description":18,"interventionNames":19},"Standard PPCI Alone","ACTIVE_COMPARATOR","Participants randomized to this arm will receive standard PPCI and guideline-directed medical therapy without routine prophylactic IABP. Rescue IABP may be used only if clinically indicated according to protocol.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Intra-Aortic Balloon Pump","Intra-aortic balloon counterpulsation initiated before opening the infarct-related artery and maintained according to protocol.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","Primary Percutaneous Coronary Intervention","Standard primary percutaneous coronary intervention for infarct-related artery reperfusion.",[9,16],[33],{"name":34,"affiliation":5,"role":35},"Yuguo Chen","STUDY_CHAIR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Chuanbao Li, MD","CONTACT","+86 18560083097","lichuanbao@qiluhospital.cn",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Yuguo Chen, MD","+86 18560085555","chen919085@126.com",[47,64,78,92],{"facility":48,"status":26,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Qilu Hospital of Shandong University, Jinan, Shandong, China","Jinan","Shandong","250012","China","CN",{"type":55,"coordinates":56},"Point",[57,58],116.99722,36.66833,{"lat":58,"lon":57},[61,63],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":62},"bao2460@126.com",{"name":43,"role":39,"phone":26,"phoneExt":26,"email":26},{"facility":65,"status":26,"city":66,"state":50,"zip":67,"country":52,"countryCode":53,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Jining No.1 People's Hospital","Jining","272011",{"type":55,"coordinates":69},[70,71],116.58139,35.405,{"lat":71,"lon":70},[74],{"name":75,"role":39,"phone":76,"phoneExt":26,"email":77},"Daqing Song, MD","+86 537 2253115","songdq_jn@163.com",{"facility":79,"status":26,"city":80,"state":50,"zip":81,"country":52,"countryCode":53,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"The Affiliated Hospital of Qingdao University","Qingdao","266003",{"type":55,"coordinates":83},[84,85],120.38042,36.06488,{"lat":85,"lon":84},[88],{"name":89,"role":39,"phone":90,"phoneExt":26,"email":91},"Peng Li, MD","+86 532 82911101","lipeng_qdu@163.com",{"facility":93,"status":26,"city":94,"state":26,"zip":95,"country":52,"countryCode":53,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Fuwai Hospital, Chinese Academy of Medical Sciences","Beijing","100037",{"type":55,"coordinates":97},[98,99],116.39723,39.9075,{"lat":99,"lon":98},[102],{"name":103,"role":39,"phone":104,"phoneExt":26,"email":105},"Qing Gu, MD, PhD","+86 10 88396009","guqingfw@126.com",{"type":107,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100651448","prophylactic-iabp-in-delayed-presentation-anterior-stemi-100651448",false,"NCT07761455","Prophylactic IABP in Delayed-Presentation Anterior STEMI","Prophylactic Intra-Aortic Balloon Counterpulsation for Delayed-Presentation Anterior ST-Segment Elevation Myocardial Infarction: A Prospective, Multicenter, Randomized Controlled Trial (PROACTIVE-AMI)","PROACTIVE-AMI","Inclusion Criteria:\n\n1. Age ≥ 18 years.\n2. First electrocardiogram on arrival shows ST-segment elevation ≥ 2 mm in at least two contiguous anterior leads, or sum of ST-segment elevation ≥ 4 mm in anterior leads.\n3. Ischemic symptoms (chest pain, chest tightness, upper abdominal discomfort, left shoulder radiation, etc.) onset to hospital arrival between ≥ 4 hours and ≤ 12 hours, and planned for primary PCI.\n4. Coronary angiography confirms the infarct-related artery is the proximal left anterior descending (LAD) (before the first septal branch or first diagonal branch) with TIMI flow grade 0 (total occlusion).\n5. Patient or legal representative provides written informed consent.\n\nExclusion Criteria:\n\n1. Established cardiogenic shock (systolic blood pressure \\\u003C 90 mmHg without inotropes\u002Fvasopressors, or requiring vasopressors to maintain systolic blood pressure ≥ 90 mmHg, AND blood lactate \\> 2.0 mmol\u002FL).\n2. Severe heart failure: Killip class ≥ III, or requiring non-invasive\u002Finvasive positive pressure ventilation before enrollment.\n3. Malignant arrhythmias, including cardiac arrest, ventricular fibrillation, ventricular flutter, pulseless ventricular tachycardia, or high-grade atrioventricular block.\n4. Severe mechanical complications (e.g., free wall rupture, ventricular septal defect, acute severe mitral regurgitation).\n5. Contraindications to IABP (severe peripheral vascular disease, aortic dissection, known aortic aneurysm, moderate-to-severe aortic regurgitation).\n6. Prior myocardial infarction or known chronic heart failure (left ventricular ejection fraction \\\u003C 50%).\n7. Prior coronary artery bypass grafting (CABG).\n8. Stroke within 1 month, or history of hemorrhagic stroke at any time.\n9. Active gastrointestinal bleeding within 3 months, or gastrointestinal diseases with increased bleeding risk.\n10. Received thrombolytic therapy for this episode.\n11. Initiation of any mechanical circulatory support (IABP, Impella, ECMO) before coronary angiography.\n12. Severe hepatic insufficiency (Child-Pugh C, or ALT \\>5×ULN with total bilirubin \\>3×ULN), renal insufficiency (eGFR \\\u003C 15 mL\u002Fmin\u002F1.73 m² or chronic dialysis), or end-stage disease with life expectancy \\\u003C 1 year.\n13. Pregnancy or lactation.\n14. Currently participating in another interventional trial.","ALL","18 Years",{"count":119,"type":120},504,"ESTIMATED","INTERVENTIONAL",[123],"NA","PROACTIVE-AMI is a prospective, multicenter, randomized, open-label trial with blinded endpoint adjudication evaluating whether prophylactic intra-aortic balloon counterpulsation (IABP) initiated before primary percutaneous coronary intervention (PPCI) improves clinical outcomes in patients with delayed-presentation acute anterior ST-segment elevation myocardial infarction (STEMI). Eligible patients are adults aged ≥18 years who present 4 to 12 hours after symptom onset, have electrocardiographic evidence of anterior STEMI with proximal left anterior descending artery total occlusion (TIMI flow 0), and are planned for PPCI. Participants will be randomized 1:1 to pre-PPCI IABP plus standard PPCI or standard PPCI alone. The primary endpoint is 180-day major adverse cardiovascular events (MACE), defined as a composite of all-cause death, cardiogenic shock, and new or worsening heart failure. Secondary outcomes include individual MACE components, cardiac death, length of stay, NT-proBNP, left ventricular ejection fraction, and left ventricular end-diastolic volume. Safety outcomes include major bleeding, vascular complications, thrombocytopenia, and stroke.",[126],"Acute Anterior ST-Segment Elevation Myocardial Infarction",[128,129,130,131,132,133,134,135],"STEMI","Anterior myocardial infarction","Delayed presentation","Intra-aortic balloon pump","IABP","Primary PCI","Percutaneous coronary intervention","Mechanical circulatory support","NOT_YET_RECRUITING","2026-08-10",{"date":139,"type":140},"2026-08-12","ACTUAL",{"date":142,"type":120},"2026-08-01",{"date":144,"type":120},"2028-07-31",{"name":5,"class":6},4]