[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627322":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":28,"locations":37,"responsibleParty":54,"collaborators":19,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":19,"enrollmentInfo":67,"targetDuration":19,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":83,"whyStopped":19,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"East Carolina University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with end-stage kidney disease (ESKD) requiring continuous renal replacement therapy (CRRT).","EXPERIMENTAL","This cohort will include adult patients with end-stage kidney disease (ESKD) receiving chronic outpatient hemodialysis who are admitted to the Intensive Care Unit (ICU) and require continuous renal replacement therapy (CRRT). Eligible participants must have a mature, functional permanent vascular access used for outpatient hemodialysis, defined as either a functioning arteriovenous fistula (AVF) or a functioning arteriovenous graft (AVG). Patients must meet the inclusion and exclusion criteria prior to enrollment.",[13],"Other: Cannulation of permanent dialysis access, for the purpose of delivering continuous renal replacement therapy.",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Cannulation of permanent dialysis access, for the purpose of delivering continuous renal replacement therapy.","Permanent dialysis access, including arteriovenous fistulas or grafts, will be cannulated using standard dialysis needles for the purpose of delivering continuous renal replacement therapy.\n\nCRRT via arteriovenous access will only be performed in ICU settings where nursing staff have at least one year of ICU experience and have completed both study-specific training and institutional CRRT training. Dialysis nurses will perform cannulation of the arteriovenous access according to the standardized operating procedure.",[9],null,[21,25],{"name":22,"affiliation":23,"role":24},"Armando F Rodriguez Lopez, MD","ECU Health Medical Center","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":23,"role":27},"Iskra Myers, MD","STUDY_DIRECTOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":19,"email":33},"Armando Rodriguez Lopez, MD","CONTACT","+19392750483","rodriguezlopeza23@ecu.edu",{"name":26,"role":31,"phone":35,"phoneExt":19,"email":36},"914-282-4448","myersi20@ecu.edu",[38],{"facility":39,"status":19,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"East Carolina University Medical Center","Greenville","North Carolina","27834","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-77.36635,35.61266,{"lat":49,"lon":48},[52],{"name":22,"role":31,"phone":53,"phoneExt":19,"email":33},"9392750483",{"type":24,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Armando Rodriguez Lopez","Doctor in Medicine","100627322","prospective-analysis-of-arteriovenous-access-ava-use-in-continuous-renal-replacement-therapy-a-feasibility-project-100627322",false,"NCT07447128","Prospective Analysis of Arteriovenous Access (AVA) Use in Continuous Renal Replacement Therapy: A Feasibility Project","Prospective Analysis of Arteriovenous Access Use in Continuous Renal Replacement Therapy, a Feasibility Project","CRRT","Inclusion Criteria:\n\n1. Age ≥18 years.\n2. ESKD patients on chronic hemodialysis for \\>1 year in duration who are admitted to the ICU and in need of CRRT.\n3. Anticipated CRRT duration ≥24 hours, based on clinical assessment of the renal trajectory.\n4. Patient with functioning arteriovenous access, either arteriovenous fistula or arteriovenous graft.\n5. Expected mechanical ventilation for a minimum of 12 hours, based on clinical assessment of the underlying diagnosis.\n6. Expected Richmond Agitation Sedation Scale (RASS) goal of 0 or less for a minimum of 12 hours, based on clinical assessment of the underlying diagnosis.\n7. Patients able to tolerate placement of an arm board at the vascular access site.\n8. Baseline AVA blood flow of at least 600 mL\u002Fmin for AVG and 500 mL\u002Fmin for AVF during ultrasonography evaluation upon enrollment.\n\nExclusion Criteria:\n\n1. Age less than 18 years old.\n2. Patients who receive dialysis via hemodialysis catheter or existing central catheter suitable for hemodialysis.\n3. ESKD patients who, at the time of enrollment, have a sacral pressure ulcer or other clinically significant skin integrity impairment requiring frequent repositioning, extensive patient rotation, or advanced wound care management.\n4. Patients with elevated INR above 5 at the time of study enrollment.\n5. Patients with acute liver failure, defined as AST \\>1000 U\u002FL and\u002For ALT \\>1000 U\u002FL at the time of study enrollment.\n6. Patients with a platelet count of less than 50,000 (10⁹ plt\u002FL) at the time of study enrollment.\n7. Patients with evidence of disseminated intravascular coagulation at the time of study enrollment.\n8. Known pregnancy at the time of study enrollment.\n9. Patients at high risk for rapid clinical deterioration, or those deemed unsuitable for AVA-based CRRT by the prescribing nephrologist or ICU physician.","ALL","18 Years",{"count":68,"type":69},50,"ESTIMATED","INTERVENTIONAL",[72],"NA","This study will test whether patients who already have a permanent dialysis access (an arteriovenous fistula or graft) can safely use that access for continuous dialysis (CRRT) while they are critically ill in the intensive care unit, instead of requiring a temporary central venous catheter. About 50 patients will participate. Researchers will monitor how well the access works, whether any complications occur, and whether there are differences between fistulas and grafts. The goal is to determine whether using a patient's existing dialysis access is a safe and practical option that could reduce the need for temporary catheters and their associated risks, such as infection and bleeding.",[75,76],"Continuous Renal Replacement Therapy (CRRT)","End Stage Kidney Disease (ESRD)",[78,79,63,80,81,82],"Arteriovenous access","Continuous Renal Replacement Therapy","AVA","ESKD","End Stage Kidney Disease","NOT_YET_RECRUITING","2026-07-01",{"date":86,"type":87},"2026-07-06","ACTUAL",{"date":89,"type":69},"2026-07-27",{"date":91,"type":69},"2027-12-31",{"name":5,"class":6},1]