[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100268928":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":37,"studyPopulation":38,"armGroups":39,"interventions":34,"overallOfficials":61,"centralContacts":65,"locations":73,"responsibleParty":276,"collaborators":34,"id":279,"slug":280,"hasResults":281,"nctId":282,"briefTitle":283,"officialTitle":283,"acronym":284,"eligibilityCriteria":285,"healthyVolunteers":281,"sex":286,"minAge":34,"maxAge":34,"enrollmentInfo":287,"targetDuration":34,"studyType":290,"phases":34,"briefSummary":291,"conditions":292,"keywords":298,"overallStatus":153,"whyStopped":34,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":326},{"fullName":5,"class":6},"Mayo Clinic","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"inflammatory blood and urinary biomarkers","Statistically significant changes (increase or decrease) in inflammatory urinary biomarkers compared to reference values","Annually for 5 years",[14],{"measure":15,"description":16,"timeFrame":12},"Longitudinal changes in eGFR","changes in eGFR during the 5 years",[18,21,24,27,30],{"measure":19,"description":20,"timeFrame":12},"Development of new onset CKD","Development of new onset CKD stage 4 (eGFR\\\u003C30) or stage 5 (eGFR\\\u003C15)",{"measure":22,"description":23,"timeFrame":12},"Lithogenic substances in the urine","Quantity of change in the substance in the urine",{"measure":25,"description":26,"timeFrame":12},"Protein in the urine","change in protein in the urine",{"measure":28,"description":29,"timeFrame":12},"Stone events","change in number of stone events",{"measure":31,"description":32,"timeFrame":12},"Quality of Life","change in the quality of life score",{"allocation":34,"interventionModel":34,"interventionModelDescription":34,"primaryPurpose":34,"observationalModel":35,"timePerspective":36,"maskingInfo":34},null,"COHORT","PROSPECTIVE","Severe, hereditary forms of nephrolithiasis cause marked excretion of insoluble minerals important in stone formation, including primary hyperoxaluria, cystinuria, Dent disease, and adenine phosphoribosyltransferase deficiency (APRTd). Patients with these disorders experience recurring stones from childhood and are at high risk for chronic kidney disease caused by crystal nephropathy. Enteric hyperoxaluria is an acquired disease characterized by hyperoxaluria and calcium oxalate crystal nephropathy associated with chronic kidney disease, and in that respect similar to the inherited stone diseases. The investigators will collect longitudinal data of individual patients in order to provide clues about potentially modifiable factors that influence disease severity and identify factors leading to kidney injury. the investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow to better evaluate mechanisms of renal dysfunction in these diseases.","Individuals with Primary Hyperoxaluria, Dent Disease, Cystinuria and APRT Deficiency, Lowe syndrome, Dent Disease Carriers and Enteric Hyperoxaluria",[40,43,46,49,52,55,58],{"label":41,"type":34,"description":42,"interventionNames":34},"Primary Hyperoxaluria Patients","Patients with confirmed diagnosis of Primary Hyperoxaluria.",{"label":44,"type":34,"description":45,"interventionNames":34},"Dent Disease Patients","Patients with confirmed diagnosis of Dent Disease.",{"label":47,"type":34,"description":48,"interventionNames":34},"Cystinuria Patients","Patients with confirmed diagnosis of Cystinuria.",{"label":50,"type":34,"description":51,"interventionNames":34},"APRT deficiency Patients","Patients with confirmed diagnosis of adenine phosphoribosyltransferase deficiency (APRTd)",{"label":53,"type":34,"description":54,"interventionNames":34},"Lowe Syndrome or Dent 2 patients","Patients with confirmed diagnosis of Lowe Syndrome or Dent 2.",{"label":56,"type":34,"description":57,"interventionNames":34},"Dent 1 carriers","Patients with confirmed diagnosis of Dent 1. Dent 1 carriers",{"label":59,"type":34,"description":60,"interventionNames":34},"Enteric Hyperoxaluria Patients","Patients with confirmed diagnosis enteric hyperoxaluria.",[62],{"name":63,"affiliation":5,"role":64},"John Lieske, MD","PRINCIPAL_INVESTIGATOR",[66,71],{"name":67,"role":68,"phone":69,"phoneExt":34,"email":70},"Barb Seide","CONTACT","800-270-4637","RareKidneyStones@mayo.edu",{"name":72,"role":68,"phone":69,"phoneExt":34,"email":70},"Julie Olson, RN",[74,95,115,131,151,169,189,206,223,244,261],{"facility":75,"status":76,"city":77,"state":78,"zip":79,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":87,"contacts":88},"University of Alabama @ Birmingham","NOT_YET_RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":83,"coordinates":84},"Point",[85,86],-86.80249,33.52066,{"lat":86,"lon":85},[89,93],{"name":90,"role":68,"phone":91,"phoneExt":34,"email":92},"Lisa Harvey","205-996-2613","lharvey@uab.edu",{"name":94,"role":64,"phone":34,"phoneExt":34,"email":34},"Dean Assimos, MD",{"facility":96,"status":76,"city":97,"state":98,"zip":99,"country":80,"countryCode":81,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Mayo Clinic Jacksonville","Jacksonville","Florida","32224",{"type":83,"coordinates":101},[102,103],-81.65565,30.33218,{"lat":103,"lon":102},[106,110,113],{"name":107,"role":68,"phone":108,"phoneExt":34,"email":109},"Arta Palaj","904-953-3071","palaj.arta@mayo.edu",{"name":111,"role":68,"phone":34,"phoneExt":34,"email":112},"Ivan Porter, MD","porter.ivan@mayo.edu",{"name":114,"role":64,"phone":34,"phoneExt":34,"email":34},"William Haley, MD",{"facility":116,"status":76,"city":117,"state":118,"zip":119,"country":80,"countryCode":81,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Children's Memorial Hospital","Chicago","Illinois","60614",{"type":83,"coordinates":121},[122,123],-87.65005,41.85003,{"lat":123,"lon":122},[126,129],{"name":127,"role":68,"phone":34,"phoneExt":34,"email":128},"Heather Price, MS","hprice@childrensmemorial.org",{"name":130,"role":64,"phone":34,"phoneExt":34,"email":34},"Craig Langman, M.D.",{"facility":132,"status":76,"city":133,"state":134,"zip":135,"country":80,"countryCode":81,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"Children's Hospital, Harvard Medical School","Boston","Massachusetts","02115",{"type":83,"coordinates":137},[138,139],-71.05977,42.35843,{"lat":139,"lon":138},[142,146,149],{"name":143,"role":68,"phone":144,"phoneExt":34,"email":145},"Leslie Spaneas","617-355-6129","leslie.spaneas@childrens.harvard.edu",{"name":147,"role":68,"phone":34,"phoneExt":34,"email":148},"Michael Somers, MD","michael.somers@childrens.harvard.edu",{"name":150,"role":64,"phone":34,"phoneExt":34,"email":34},"Michelle Baum, MD",{"facility":152,"status":153,"city":154,"state":155,"zip":156,"country":80,"countryCode":81,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Mayo Clinic Hyperoxaluria Center","RECRUITING","Rochester","Minnesota","55905",{"type":83,"coordinates":158},[159,160],-92.4699,44.02163,{"lat":160,"lon":159},[163,165,167],{"name":67,"role":68,"phone":69,"phoneExt":34,"email":164},"hyperoxaluriacenter@mayo.edu",{"name":166,"role":68,"phone":69,"phoneExt":34,"email":164},"Julie B Olson, RN",{"name":168,"role":64,"phone":34,"phoneExt":34,"email":34},"Dawn Milliner, MD",{"facility":170,"status":76,"city":171,"state":171,"zip":172,"country":80,"countryCode":81,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"New York University","New York","10010",{"type":83,"coordinates":174},[175,176],-74.00597,40.71427,{"lat":176,"lon":175},[179,184,187],{"name":180,"role":68,"phone":181,"phoneExt":182,"email":183},"Frank Modersitzki, MPH","216-686-7500","6379","Frank.Modersitzki@nyumc.org",{"name":185,"role":68,"phone":34,"phoneExt":34,"email":186},"Lada Beara-Lasic, MD","lada.bearalasic@nymc.org",{"name":188,"role":64,"phone":34,"phoneExt":34,"email":34},"David Goldfarb, MD",{"facility":190,"status":76,"city":191,"state":192,"zip":193,"country":80,"countryCode":81,"cosmosGeoPoint":194,"geoPoint":198,"contacts":199},"Cincinnati Children's Hosptial Medical Center","Cincinnati","Ohio","45229",{"type":83,"coordinates":195},[196,197],-84.51439,39.12711,{"lat":197,"lon":196},[200,204],{"name":201,"role":68,"phone":202,"phoneExt":34,"email":203},"Prasad Devarajan, MD","515-636-4200","prasad.devarajan@cchmc.org",{"name":205,"role":64,"phone":34,"phoneExt":34,"email":34},"Prasad Decarajan, MD",{"facility":207,"status":76,"city":208,"state":209,"zip":210,"country":80,"countryCode":81,"cosmosGeoPoint":211,"geoPoint":215,"contacts":216},"Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"type":83,"coordinates":212},[213,214],-75.16362,39.95238,{"lat":214,"lon":213},[217,221],{"name":218,"role":68,"phone":219,"phoneExt":34,"email":220},"Taylor Moatz","267-425-3937","moatzt@chop.edu",{"name":222,"role":64,"phone":34,"phoneExt":34,"email":34},"Lawrence Copelovitch, MD",{"facility":224,"status":76,"city":225,"state":226,"zip":227,"country":228,"countryCode":229,"cosmosGeoPoint":230,"geoPoint":234,"contacts":235},"Hosptial of Sick Children","Toronto","Ontario","M5G 1X8","Canada","CA",{"type":83,"coordinates":231},[232,233],-79.39864,43.70643,{"lat":233,"lon":232},[236,240,243],{"name":237,"role":68,"phone":238,"phoneExt":34,"email":239},"Lisa Robinson, MD","416-813-5082","lisa.robinson@sickkids.ca",{"name":241,"role":68,"phone":238,"phoneExt":34,"email":242},"Elizabeth Harvey, MD","Elizabeth.harvey@sickkids.ca",{"name":241,"role":64,"phone":34,"phoneExt":34,"email":34},{"facility":245,"status":76,"city":246,"state":34,"zip":34,"country":247,"countryCode":248,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"Landspitali Universtiy Hospital","Reykjavik","Iceland","IS",{"type":83,"coordinates":250},[251,252],-21.89541,64.13548,{"lat":252,"lon":251},[255,259],{"name":256,"role":68,"phone":257,"phoneExt":34,"email":258},"Inger Agustsdottir, RN","354-824-5227","ingeragu@landspitali.is",{"name":260,"role":64,"phone":34,"phoneExt":34,"email":34},"Vidar Edvardsson, MD",{"facility":262,"status":76,"city":263,"state":34,"zip":34,"country":264,"countryCode":265,"cosmosGeoPoint":266,"geoPoint":270,"contacts":271},"Shaare Zedek Medica Center","Jerusalem","Israel","IL",{"type":83,"coordinates":267},[268,269],35.21633,31.76904,{"lat":269,"lon":268},[272,275],{"name":273,"role":68,"phone":34,"phoneExt":34,"email":274},"Yaacov Frishberg, MD","yaacovf@ekmd.huji.ac.il",{"name":273,"role":64,"phone":34,"phoneExt":34,"email":34},{"type":64,"investigatorFullName":277,"investigatorTitle":278,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"John Lieske","PI","100268928","prospective-research-rare-kidney-stones-prorks-100268928",false,"NCT02780297","Prospective Research Rare Kidney Stones (ProRKS)","ProRKS","Inclusion Criteria:\n\n1. Diagnosis of primary hyperoxaluria\n2. Diagnosis of enteric hyperoxaluria\n3. Diagnosis of Dent Disease\n4. Diagnosis of Cystinuria\n5. Diagnosis of adenine phosphoribosyltransferase deficiency (APRTd)\n6. Diagnosis of Lowe Syndrome\n7. Diagnosis of Dent Disease Carrier\n\nExclusion Criteria:\n\n1. Prior renal failure\n2. History of liver and\u002For kidney transplant.","ALL",{"count":288,"type":289},220,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.",[293,294,295,296,297],"Hyperoxaluria","Cystinuria","Dent Disease","Lowe Syndrome","Adenine Phosphoribosyltransferase Deficiency",[299,295,300,301,296,302,303,304,305,306,307,308,309,310,311,312,313,314,315,316],"primary hyperoxaluria","enteric hyperoxaluria","cystinuria","Adenine phosphoribosyltransferase deficiency","PH","APRTd","APRT","hyperoxaluria","oxalate","oxalosis","PH type 1","PH type 2","PH type 3","Dents","Dent","Dent 1","Dent 2","APRT deficiency","2026-08-05",{"date":319,"type":320},"2026-08-07","ACTUAL",{"date":322,"type":34},"2016-05",{"date":324,"type":289},"2028-07",{"name":5,"class":6},11]