[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584206":3},{"organization":4,"outcomesModule":7,"designInfo":31,"detailedDescription":30,"studyPopulation":30,"armGroups":37,"interventions":43,"overallOfficials":48,"centralContacts":52,"locations":57,"responsibleParty":71,"collaborators":30,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":30,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":30,"studyType":87,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":60,"whyStopped":30,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":30},[9],{"measure":10,"description":11,"timeFrame":12},"6-month oncological outcome","6-month oncological outcome after Prostate Irreversible Electroporation treatment, as defined by multiparametric MRI result of prostate","6-month after treatment",[14,18,22,26],{"measure":15,"description":16,"timeFrame":17},"6-month and 12-month functional and oncological outcome","6-month and 12-month functional and oncological outcome after Prostate Irreversible Electroporation treatment by questionnaires and multiparametric MRI result of prostate","At 6-month and 12-month after treatment",{"measure":19,"description":20,"timeFrame":21},"30-day complications","30-day complications after study intervention","at 30 day after treatment",{"measure":23,"description":24,"timeFrame":25},"Presence of histologically proven prostate cancer recurrence","Presence of histologically proven prostate cancer recurrence on biopsy in suspicious cases","At 12-month after treatment",{"measure":27,"description":28,"timeFrame":29},"PSA change","PSA change after treatment","At 3-month, 6-month, 9-month and 12-month after treatment",null,{"allocation":32,"interventionModel":33,"interventionModelDescription":30,"primaryPurpose":34,"observationalModel":30,"timePerspective":30,"maskingInfo":35},"NA","SINGLE_GROUP","TREATMENT",{"masking":36,"maskingDescription":30,"whoMasked":30},"NONE",[38],{"label":39,"type":40,"description":30,"interventionNames":41},"Prostate Irreversible Electroporation","EXPERIMENTAL",[42],"Device: Prostate Irreversible Electroporation",[44],{"type":45,"name":39,"description":46,"armGroupLabels":47,"otherNames":30},"DEVICE","The Prostate Irreversible Electroporation procedure was performed in our institution by a single urologist using an Prostate Irreversible Electroporation device and 18-gauge electrodes (Nanoknife®; Angiodynamics, Queensbury, NY, USA). All patients were positioned in lithotomy position under general anesthesia. A transrectal ultrasound was used to visualize the prostate and a brachytherapy grid was used to place the electrodes. An indwelling catheter was placed to empty the bladder. Four to six electrodes were placed through the perineum via the template grid to surround the targeted lesion. The lesion was defined based on prostate biopsy and MRI images. The active tip varied between 15- and 20-mm exposure. The distances between the electrodes were measured using TRUS and entered into the Nanoknife system. An initial ten pulses were delivered to ensure sufficient current was delivered between the electrodes (20-40 A). If sufficient then the remaining 80 pulses were given.",[39],[49],{"name":50,"affiliation":5,"role":51},"Chi Hang Yee, MBBS","PRINCIPAL_INVESTIGATOR",[53],{"name":50,"role":54,"phone":55,"phoneExt":30,"email":56},"CONTACT","+852 35053933","yeechihang@surgery.cuhk.edu.hk",[58],{"facility":59,"status":60,"city":61,"state":30,"zip":30,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"Prince of Wales Hospital, the Chinese University of Hong Kong","RECRUITING","Hong Kong","HK",{"type":64,"coordinates":65},"Point",[66,67],114.17469,22.27832,{"lat":67,"lon":66},[70],{"name":50,"role":51,"phone":30,"phoneExt":30,"email":30},{"type":51,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Chi Hang Yee","Principal Investigator","100584206","prostate-irreversible-electroporation-study-100584206",false,"NCT06886321","Prostate Irreversible Electroporation Study","Evaluation of the Effectiveness of Irreversible Electroporation for the Treatment of Prostate Cancer","Inclusion Criteria:\n\n* Men aged between 40 - 85 years\n* Visible index lesion(s) on MRI\n* Found to have localized prostate cancer after MRI-USG fusion targeted biopsy or USG-guided template biopsy: Clinical tumour stage \\\u003C=T2, or Gleason score \\\u003C=7, or PSA \\\u003C= 20 ng\u002Fml\n\nExclusion Criteria:\n\n* Patients unfit for contrast MRI exam\n* Patients with active urinary tract infection\n* Patients with bladder pathology including bladder stone and bladder cancer\n* Patients with urethral stricture\n* Patients with neurogenic bladder and\u002For sphincter abnormalities\n* Patients who fail to give informed consent","MALE","40 Years","85 Years",{"count":85,"type":86},10,"ESTIMATED","INTERVENTIONAL",[32],"Conventional treatment options for localized prostate cancer include prostatectomy, radiotherapy and active surveillance. However, prostatectomy and radiotherapy carry certain degree of morbidity, including the risks of urinary incontinence, erectile dysfunction and injury to the structures in the proximity. Active surveillance carries the risk of disease progression and psychological distress to the patients. Focal therapy employs the concept of only destroying the significant lesion, resulting in disease cure and improved functional outcome. Among the different options of focal therapy, Irreversible electroporation has evolved over the past decades and can be a reliable treatment option. Our study aims at assess the safety and effectiveness of such treatment in prostate cancer management.",[91],"Prostate Cancer",[93],"Focal therapy","2026-09-08",{"date":96,"type":97},"2026-09-10","ACTUAL",{"date":99,"type":97},"2025-06-30",{"date":101,"type":86},"2027-06-30",{"name":5,"class":6},1]