[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658855":3},{"organization":4,"outcomesModule":7,"designInfo":34,"detailedDescription":37,"studyPopulation":38,"armGroups":39,"interventions":33,"overallOfficials":43,"centralContacts":48,"locations":33,"responsibleParty":54,"collaborators":33,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":33,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":33,"studyType":71,"phases":33,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":83,"whyStopped":33,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":33},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":33},[9],{"measure":10,"description":11,"timeFrame":12},"In-Hospital Mortality","Proportion of critically ill children who die during hospital stay, assessed by review of medical records and PICU follow-up.","Up to 4 weeks",[14,17,20,23,26,30],{"measure":15,"description":16,"timeFrame":12},"PICU Length of Stay","Mean number of days spent in the Pediatric Intensive Care Unit (PICU), assessed by review of medical records.",{"measure":18,"description":19,"timeFrame":12},"Duration of Mechanical Ventilation","Mean number of days of mechanical ventilation, assessed by review of medical records.",{"measure":21,"description":22,"timeFrame":12},"Need for Vasoactive Support","Proportion of children requiring vasoactive medications during PICU stay, assessed by review of medical records.",{"measure":24,"description":25,"timeFrame":12},"Multiple Organ Dysfunction Syndrome (MODS)","Proportion of children who develop multiple organ dysfunction syndrome (MODS) during PICU stay, assessed by review of medical records.",{"measure":27,"description":28,"timeFrame":29},"Hospital Length of Stay","Mean number of days spent in the hospital, assessed by review of medical records.","Up to 8 weeks",{"measure":31,"description":32,"timeFrame":12},"Need for Renal Replacement Therapy","Proportion of children requiring renal replacement therapy during PICU stay, assessed by review of medical records.",null,{"allocation":33,"interventionModel":33,"interventionModelDescription":33,"primaryPurpose":33,"observationalModel":35,"timePerspective":36,"maskingInfo":33},"COHORT","PROSPECTIVE","Critical illness in children may progress to dysfunction of one or more organ systems, and multiple organ dysfunction is an important determinant of morbidity and mortality. The Pediatric Sequential Organ Failure Assessment (pSOFA) score evaluates six organ systems (respiratory, cardiovascular, neurological, hepatic, coagulation, and renal) in critically ill children, with each domain scored from 0 to 4 and a total score of 0-24.\n\nThis prospective observational cohort study will include 100 critically ill children admitted to the PICU of Assiut University Children's Hospital who fulfill the eligibility criteria. Demographic, clinical, and laboratory data required for pSOFA calculation will be collected. The worst value for each variable during each 24-hour period will be used to calculate the score. The primary outcome will be in-hospital mortality; secondary outcomes will include PICU length of stay, mechanical ventilation duration, vasoactive support, MODS, hospital length of stay, and renal replacement therapy.","Critically ill children aged 1 month to 18 years admitted to the Pediatric Intensive Care Unit (PICU) of Assiut University Children's Hospital who fulfill the eligibility criteria.",[40],{"label":41,"type":33,"description":42,"interventionNames":33},"Critically Ill Children Admitted to PICU","Consecutive critically ill children aged 1 month to 18 years admitted to the Pediatric Intensive Care Unit (PICU) of Assiut University Children's Hospital who fulfill the eligibility criteria and will be followed to assess pSOFA score and clinical outcomes.",[44],{"name":45,"affiliation":46,"role":47},"Emad M Hammad, prof","Pediatrics Department, Assiut University Hospitals","STUDY_CHAIR",[49],{"name":50,"role":51,"phone":52,"phoneExt":33,"email":53},"Sara H Abdellatif, Resident","CONTACT","+20 10 95752600","Sara.17289692@med.aun.edu.eg",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Sara Hussen","Resident Physician, Department of Pediatrics","100658855","psofa-score-in-predicting-mortality-in-pediatric-intensive-care-100658855",false,"NCT07858487","pSOFA Score in Predicting Mortality in Pediatric Intensive Care","Evaluation of Pediatric Sequential Organ Failure Assessment (pSOFA) Score in Predicting Mortality and Outcome in Pediatric Intensive Care Unit","Inclusion Criteria:\n\n* Age 1 month to 18 years.\n* PICU admission requiring intensive monitoring and\u002For organ support.\n* Availability of required pSOFA clinical and laboratory data.\n* Written informed consent from parent\u002Flegal guardian.\n\nExclusion Criteria:\n\n* Age less than 1 month.\n* PICU stay less than 24 hours.\n* Incomplete data required for pSOFA calculation.\n* Readmission during the same hospitalization.\n* Refusal by parent\u002Flegal guardian.","ALL","1 Month","18 Years",{"count":69,"type":70},121,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study aims to evaluate the predictive performance of the Pediatric Sequential Organ Failure Assessment (pSOFA) score for mortality and selected clinical outcomes among critically ill children admitted to the Pediatric Intensive Care Unit (PICU). A total of 100 children will be enrolled and followed during their PICU stay.",[74,75],"Critical Illness","Multiple Organ Dysfunction Syndrome",[77,78,79,80,81,82],"pSOFA score","Pediatric intensive care","Organ dysfunction","Mortality","MODS","Assiut","NOT_YET_RECRUITING","2026-09-29",{"date":86,"type":87},"2026-10-05","ACTUAL",{"date":89,"type":70},"2026-09-30",{"date":91,"type":70},"2028-02-01",{"name":5,"class":6}]