[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648048":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":19,"locations":28,"responsibleParty":43,"collaborators":18,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":18,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":18,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":70,"whyStopped":18,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Queen Mary University of London","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Psychosocial intervention","EXPERIMENTAL","A brief manualised psychosocial intervention comprising information provision, psychoeducation, goal setting, coping strategies, self-management strategies, and Cognitive Behavioural Therapy techniques (Inc. Mindfulness, cognitive reframing). The intervention will be tailored to individual needs, informed by questionnaire results, goal setting, homework activities, and open discussion.",[13],"Behavioral: Psychosocial intervention",[15],{"type":16,"name":9,"description":11,"armGroupLabels":17,"otherNames":18},"BEHAVIORAL",[9],null,[20,25],{"name":21,"role":22,"phone":23,"phoneExt":18,"email":24},"Laura Smith, PhD, PGCHE, MSc, BSc","CONTACT","+447842885047","l.j.smith@qmul.ac.uk",{"name":26,"role":22,"phone":18,"phoneExt":18,"email":27},"Alastair Noyce","A.J.Noyce@qmul.ac.uk",[29],{"facility":5,"status":18,"city":30,"state":18,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"London","E1 4NS","United Kingdom","UK",{"type":35,"coordinates":36},"Point",[37,38],-0.12574,51.50853,{"lat":38,"lon":37},[41],{"name":42,"role":22,"phone":23,"phoneExt":18,"email":24},"Laura Smith",{"type":44,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100648048","psychosocial-support-for-nitrous-oxide-misuse-100648048",false,"NCT07716293","Psychosocial Support for Nitrous Oxide Misuse","Development and Evaluation of a Psychosocial Intervention for Nitrous Oxide Misuse in East London","Inclusion Criteria:\n\n* Confirmed clinical neurological diagnosis related to N₂O use.\n* Experiencing mild to moderate psychological distress.\n* Aged 16-65 years.\n* Able to communicate in English.\n* Able and willing to give informed consent.\n\nExclusion Criteria:\n\n* Other causes of neurological symptoms.\n* Currently receiving another structured psychosocial intervention.\n* Severe psychiatric distress.","ALL","16 Years","65 Years",{"count":56,"type":57},10,"ESTIMATED","INTERVENTIONAL",[60],"NA","Nitrous oxide (laughing gas, N₂O) is the third most commonly used recreational drug among young people in the UK. Although it may seem harmless, frequent use can damage the nerves and spinal cord. Vitamin B12 injections can help treat these neurological complications, but continued N₂O use can reduce how effective this treatment is.\n\nSome people use N₂O to cope with stress or emotional difficulties, while others may find it hard to stop because of cravings or habits. These emotional and social difficulties can negatively affect recovery, wellbeing, and quality of life.\n\nOur team has developed a new brief support programme for people experiencing mild to moderate emotional and social difficulties related to N₂O use. The programme provides information and practical strategies to help people cope, manage emotions, and prevent problems from worsening. It is delivered by a trained facilitator over up to four weekly sessions, either in-person or remotely.\n\nIn this study, the support programme will be introduced to patients attending the Royal London Hospital clinic for N₂O related neurological harms. Ten participants will receive the programme alongside their usual care. Participants will complete questionnaires before and after the programme to monitor mental health, quality of life, and dependence on N₂O. The research team will evaluate whether the programme was delivered as intended and whether participants remained engaged. Participants will be invited to take part in an interview to feedback on their experiences and suggest improvements before the programme is tested in a larger study. Participation will last up to 8 hours in total over approximately 9 weeks.",[63],"Brief Psychosocial Intervention",[65,66,67,68,69],"Feasibility study","Mixed methods","Nitrous oxide","Psychological intervention","Addiction and dependence","NOT_YET_RECRUITING","2026-07-16",{"date":73,"type":74},"2026-07-21","ACTUAL",{"date":76,"type":57},"2026-09-14",{"date":78,"type":57},"2027-09-13",{"name":5,"class":6},1]