[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647858":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":46,"responsibleParty":68,"collaborators":26,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":26,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":26,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":49,"whyStopped":26,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"American University of Beirut Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IQOS Iluma i (Induction Heating)","EXPERIMENTAL","Participants use the IQOS Iluma i device with TEREA tobacco sticks under two flavor conditions (preferred flavor and standardized Amber flavor) across study visits. The IQOS Iluma i uses induction-based heating technology.",[13],"Device: IQOS Iluma i with TEREA Tobacco Sticks",{"label":15,"type":16,"description":17,"interventionNames":18},"IQOS 2.4 (Blade Heating)","ACTIVE_COMPARATOR","Participants use the IQOS 2.4 device with HEETS tobacco sticks under two flavor conditions (preferred flavor and standardized Amber flavor) across study visits. The IQOS 2.4 uses ceramic blade heating technology.",[19],"Device: IQOS 2.4 with HEETS Tobacco Sticks",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","IQOS Iluma i with TEREA Tobacco Sticks","The IQOS Iluma i is an induction-heated tobacco device used with TEREA STICKS. Participants use the device ad libitum during two smoking bouts (preferred flavor and Amber flavor conditions) across two study visits. Puff topography is recorded continuously during use.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"IQOS 2.4 with HEETS Tobacco Sticks","The IQOS 2.4 is a ceramic blade-heated tobacco device used with HEETS tobacco sticks. Participants use the device ad libitum during two smoking bouts (preferred flavor and Amber flavor conditions) across two study visits. Puff topography is recorded continuously during use.",[15],[32],{"name":33,"affiliation":5,"role":34},"Soha Talih","PRINCIPAL_INVESTIGATOR",[36,42],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Soha Talih, PhD","CONTACT","+961-1-350000","3627","st38@aub.edu.lb",{"name":43,"role":38,"phone":44,"phoneExt":26,"email":45},"Mario El Hourani, PhD","+96170715263","me217@aub.edu.lb",[47,64],{"facility":48,"status":49,"city":50,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Clinical Aerosol Technology Laboratory (CATLAB), American University of Beirut","RECRUITING","Beirut","1107 2020","Lebanon","LB",{"type":55,"coordinates":56},"Point",[57,58],35.50157,33.89332,{"lat":58,"lon":57},[61],{"name":62,"role":38,"phone":63,"phoneExt":40,"email":41},"Dr. Soha Talih, PHD","+9611350000",{"facility":48,"status":49,"city":50,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":65,"geoPoint":67,"contacts":26},{"type":55,"coordinates":66},[57,58],{"lat":58,"lon":57},{"type":69,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100647858","puff-topography-and-sensory-effects-across-iqos-device-generations-100647858",false,"NCT07712887","Puff Topography and Sensory Effects Across IQOS Device Generations","Puff Topography and Sensory Effects Across IQOS Device Generations: A Randomized Crossover Study","Inclusion Criteria:\n\n* Current IQOS user (at least 3 days per week in the past 30 days)\n* Age 18 to 65 years\n* Generally healthy\n* Willing to provide informed written consent\n* Willing to attend all laboratory visits\n* Willing to abstain from all nicotine and tobacco products for at least 12 hours before each visit\n\nExclusion Criteria:\n\n* Use of any tobacco products other than IQOS in the past 30 days\n* Chronic cardiovascular conditions, seizures, or abnormal blood pressure\n* Current psychiatric disorder requiring active treatment, including major depressive disorder\n* Regular use of prescription medications that may influence cardiovascular function, respiratory function, or nicotine metabolism (excluding vitamins or birth control)\n* Use of cocaine, opioids, benzodiazepines, or methamphetamines in the past month\n* Marijuana use on more than 15 days per month\n* Current pregnancy or breastfeeding\n* Plans to quit nicotine or tobacco products within the next 30 days",true,"ALL","18 Years","65 Years",{"count":82,"type":83},50,"ESTIMATED","INTERVENTIONAL",[86],"NA","The goal of this clinical trial is to learn how people use two generations of IQOS heated tobacco devices and how each device affects their smoking behavior and sensory experience.\n\nThe main questions it aims to answer are:\n\n* Do participants puff differently when using the newer IQOS Iluma i compared to the older IQOS 2.4?\n* Does the flavor of the tobacco stick (preferred flavor vs. standard tobacco flavor) affect puffing behavior or sensory experience?\n* What are the differences in throat hit, mouthfeel, and satisfaction between the two devices?\n\nParticipants will:\n\n* Attend 2 laboratory visits at the American University of Beirut\n* Use both the IQOS Iluma i and IQOS 2.4 devices during each visit\n* Have their puffing behavior recorded automatically during device use\n* Provide a breath sample before and after each use session\n* Complete short questionnaires about how each device felt and their urge to smoke",[89,90],"Nicotine Dependence","Tobacco Use",[92,93,94,95,96,97,98],"Heated Tobacco Products","IQOS","Puff Topography","Electronic Nicotine Delivery Systems","Nicotine","Subjective Effects","Tobacco Harm Reduction","2026-07-29",{"date":101,"type":102},"2026-07-30","ACTUAL",{"date":104,"type":102},"2026-07-27",{"date":106,"type":83},"2027-12-15",{"name":5,"class":6},2]