[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647375":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":30,"locations":40,"responsibleParty":56,"collaborators":21,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":21,"enrollmentInfo":68,"targetDuration":21,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":82,"whyStopped":21,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Centre Hospitalier Régional d'Orléans","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Imaging (PET and CZT-SPECT\u002FCT) arm","EXPERIMENTAL","Study including patients with chronic coronary syndrome and intermediate coronary lesions requiring functional assessment. At inclusion (J0), participants receive a myocardial perfusion PET scan using Rubidium-82 for the quantification of myocardial blood flow (MBF) and myocardial flow reserve (MFR). During pharmacological stress induced by a coronary vasodilator agent, an additional intravenous injection of 99mTc-tetrofosmin is administered for SPECT imaging. A stress CZT-SPECT\u002FCT acquisition is performed immediately following the PET scan under same stress conditions. Within a maximum of 7 days after the initial imaging session, participants return for a resting CZT-SPECT\u002FCT acquisition (J1), with a minimum interval of 24 hours after the stress acquisition. Hemodynamic parameters are recorded during imaging to allow assessment of potential variability. Quantitative analysis of myocardial perfusion is performed using dedicated software to derive SUV from SPECT imaging.",[13,14],"Diagnostic Test: stress SPECT\u002FCT","Diagnostic Test: rest SPECT\u002FCT",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","stress SPECT\u002FCT","During pharmacological stress induced by a coronary vasodilator agent, an intravenous injection of 99mTc-tetrofosmin is administered for single-photon emission computed tomography (SPECT) imaging.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"rest SPECT\u002FCT","A resting CZT-SPECT\u002FCT acquisition (J1), with a minimum interval of 24 hours after the stress acquisition.",[9],[27],{"name":28,"affiliation":5,"role":29},"Matthieu BAILLY, Professor","PRINCIPAL_INVESTIGATOR",[31,36],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","0238575078","+33","matthieu.bailly@chu-orleans.fr",{"name":37,"role":32,"phone":38,"phoneExt":34,"email":39},"Fanny LOUAT","0238744295","fanny.louat@chu-orleans.fr",[41],{"facility":42,"status":21,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Centre Hospitalier Universitaire d'Orléans","Orléans","Loiret","45067","France","FR",{"type":49,"coordinates":50},"Point",[51,52],1.90407,47.90248,{"lat":52,"lon":51},[55],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},{"type":57,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100647375","quantitative-myocardial-perfusion-imaging-assessment-by-spectct-100647375",false,"NCT07708805","Quantitative Myocardial Perfusion Imaging Assessment by SPECT\u002FCT","Quantitative Myocardial Perfusion Imaging Assessment by SPECT\u002FCT: Evaluation of Standardized Uptake Value (SUV) and Correlation With Myocardial Flow Reserve (MFR) Assessed by PET\u002FCT","SUV-RESERVE","Inclusion Criteria:\n\n1. Participant has provided informed consent to participate in the study.\n2. Age ≥ 18 years.\n3. Patients referred for functional cardiac imaging assessment (SPECT or PET) following diagnostic coronary CT angiography (CCTA) or invasive coronary angiography demonstrating either:\n\n   * moderate coronary atherosclerosis without significant coronary stenosis (\\\u003C50% stenosis), or\n   * coronary lesions for which functional cardiac imaging assessment or medical therapy is indicated.\n\nExclusion Criteria:\n\n1. Severe coronary artery disease requiring prompt revascularization by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), including left main coronary artery stenosis \\>50% or other severe coronary lesions with FFR \\\u003C0.80.\n2. History of coronary revascularization (PCI, coronary stenting, or CABG).\n3. Left ventricular ejection fraction (LVEF) \\\u003C35%.\n4. Contraindication to pharmacological stress testing for cardiac PET\u002FSPECT, including severe hypotension, second- or third-degree atrioventricular block, or recent myocardial infarction.\n5. Protected adult under legal guardianship or curatorship.\n6. Individual under judicial protection measures.\n7. Individual deprived of liberty.\n8. Individual not affiliated with a health insurance\n9. Pregnant or breastfeeding woman.","ALL","18 Years",{"count":69,"type":70},30,"ESTIMATED","INTERVENTIONAL",[73],"NA","Myocardial perfusion single-photon emission computed tomography (SPECT) is a well-established functional imaging technique for the assessment of coronary artery disease. Recent developments in cadmium-zinc-telluride (CZT) camera technology have enabled significant reductions in acquisition time while improving image quality. Positron emission tomography (PET) myocardial imaging remains the reference standard for the quantitative assessment of myocardial blood flow (MBF) and myocardial flow reserve (MFR); however, its use is limited by high costs and restricted availability.\n\nThis exploratory study aims to evaluate the feasibility of using CZT-SPECT\u002FCT imaging as an alternative approach by assessing the absolute quantification of myocardial tracer uptake, expressed as standardized uptake values (SUV), both at rest and during stress. The primary objective is to compare the ratio of stress-to-rest SUV obtained from SPECT with MFR values measured using PET imaging.\n\nPatients under cardiology care at the University Hospital of Orléans who are scheduled for diagnostic coronary angiography or coronary CT angiography will be invited to participate. The study procedures will be integrated into their routine clinical workflow. On Day 0, participants will undergo a PET myocardial perfusion study using Rubidium-82, including measurement of MBF and MFR, with concomitant administration of 99mTc-tetrofosmin under pharmacological stress using the same vasodilator agent. A stress CZT-SPECT\u002FCT acquisition will then be performed immediately after the PET scan. Within seven days of the initial evaluation, participants will undergo a rest CZT-SPECT\u002FCT acquisition. Quantitative analysis of myocardial tracer uptake will subsequently be performed to derive SUV values.\n\nThe overall goal of this feasibility study is to generate preliminary data to support the design of a larger-scale clinical study. Ultimately, the study seeks to determine whether standard CZT-SPECT\u002FCT imaging could provide a simpler, faster, and more widely accessible alternative to PET myocardial perfusion imaging for functional myocardial assessment.",[76,77],"Coronary Artery Disease","Chronic Coronary Syndrome",[79,80,81],"Myocardial perfusion SPECT","myocardial flow reserve","Standardized Uptake Value","NOT_YET_RECRUITING","2026-07-16",{"date":85,"type":86},"2026-07-17","ACTUAL",{"date":88,"type":70},"2026-08-25",{"date":90,"type":70},"2027-11-25",{"name":5,"class":6},1]