[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541490":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":33,"responsibleParty":53,"collaborators":19,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":19,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":19,"enrollmentInfo":66,"targetDuration":19,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":36,"whyStopped":19,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Dartmouth-Hitchcock Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with Dupuytren's Contacture","EXPERIMENTAL","Patients with Dupuytren's Contacture will undergo Collagenase Clostridium Histolyticum injection and release followed by two 5-day courses of radiation therapy separated by 6-8 weeks. They will then be followed for 3 years for recurrence.",[13],"Radiation: Radiation therapy",[15],{"type":16,"name":17,"description":11,"armGroupLabels":18,"otherNames":19},"RADIATION","Radiation therapy",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Lance Warhold, MD","Dartmouth Health","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"Peter A DePalo, BS, CCRP","CONTACT","603 653-0494","peter.a.depalo.sr@hitchcock.org",{"name":22,"role":28,"phone":32,"phoneExt":19,"email":19},"603 650-5133",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Dartmouth Hitchcock","RECRUITING","Lebanon","New Hampshire","03766","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-72.25176,43.64229,{"lat":46,"lon":45},[49],{"name":50,"role":28,"phone":51,"phoneExt":19,"email":52},"Julia Schwarz, MD","6036505133","julia.s.schwarz@hitchcock.org",{"type":24,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Lance G. Warhold","Staff Physican, Principal Investigator","100541490","radiation-therapy-for-dupuytrens-contracture-following-non-surgical-release-100541490",false,"NCT06330545","Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release","A Prospective Clinical Trial of Radiation Therapy for Dupuytren's Contracture Following Surgical and Non-Surgical Release","Inclusion Criteria:\n\n* Age 45 or greater with DC\n* Extension deficit \\>10 degrees\n* Unable to simultaneously place the affected finger and palm flat on a table.\n* Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.\n* For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included\n\nExclusion Criteria:\n\n* Unsuccessful non-surgical release (\\> N\u002F1 disease)\n* They develop an open wound during CCH\n* Breast feeding or pregnancy\n* A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.\n* Less than the age of 45\n* They have previously undergone radiation on the hand in which they plan to get CCH injections\n* They are pregnant women, impaired adults or prisoners",true,"ALL","45 Years",{"count":67,"type":68},95,"ESTIMATED","INTERVENTIONAL",[71],"NA","The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are:\n\n• Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum?\n\nParticipants will undergo:\n\n* Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection\n* Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy",[74],"Dupuytren Contracture",[76,77],"Dupuytren's contracture","radiation therapy","2026-07-24",{"date":80,"type":81},"2026-07-28","ACTUAL",{"date":83,"type":81},"2024-09-16",{"date":85,"type":68},"2032-04",{"name":5,"class":6},1]