[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100386033":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":64,"collaborators":23,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":23,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":46,"whyStopped":23,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University Medical Center Mainz","OTHER",[8,14],{"label":9,"type":10,"description":9,"interventionNames":11},"Robot assisted minimally invasive esophagectomy","EXPERIMENTAL",[12,13],"Procedure: Minimally invasive esophagectomy","Device: daVinci Xi system",{"label":15,"type":16,"description":17,"interventionNames":18},"Minimally invasive esophagectomy","ACTIVE_COMPARATOR","Conventional minimally invasive esophagectomy",[12],[20,24],{"type":21,"name":15,"description":17,"armGroupLabels":22,"otherNames":23},"PROCEDURE",[15,9],null,{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":23},"DEVICE","daVinci Xi system","robot assisted minimally invasive esophagectomy",[9],[30],{"name":31,"affiliation":32,"role":33},"Peter Grimminger, MD,PhD","JGU Medizin Mainz, dept. AVTC","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":23,"email":39},"Pieter Christiaan van der Sluis, MD,PhD","CONTACT","+31628880709","p.c.vandersluis-2@umcutrecht.nl",{"name":41,"role":37,"phone":42,"phoneExt":23,"email":43},"Evangelos Tagkalos, MD","+4917673865294","evangelos.tagkalos@unimedizin-mainz.de",[45],{"facility":5,"status":46,"city":47,"state":23,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Mainz","55131","Germany","DE",{"type":52,"coordinates":53},"Point",[54,55],8.28008,49.98185,{"lat":55,"lon":54},[58,62],{"name":59,"role":37,"phone":60,"phoneExt":23,"email":61},"Peter P Grimminger, MD","+496131177291","peter.grimminger@unimedizin-mainz.de",{"name":63,"role":37,"phone":60,"phoneExt":23,"email":43},"Evangelos Tagkalos, MD,MHBA",{"type":33,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Peter Grimminger","Principle investigator","100386033","ramie-versus-mie-for-resectable-esophageal-cancer-a-randomized-controlled-trial-robot-2-trial-100386033",false,"NCT04306458","RAMIE Versus MIE for Resectable Esophageal Cancer, a Randomized Controlled Trial (ROBOT-2 Trial).","Robot-assisted Minimally Invasive Thoraco-laparoscopic Esophagectomy Versus Minimally Invasive Esophagectomy for Resectable Esophageal Cancer, a Randomized Controlled Trial (ROBOT-2 Trial).","ROBOT-2","Inclusion Criteria:\n\n* Histologically proven adenocarcinoma of the intrathoracic esophagus and gastroesophageal junction (including Siewert I and II)\n* Surgically resectable (T1-4a, N0-3, M0)\n* Age ≥ 18 and ≤ 90 years\n* European Clinical Oncology Group (ECOG) performance status 0,1 or 2\n* Written informed consent\n\nExclusion Criteria:\n\n* Esophageal squamous cell carcinoma\n* Carcinoma of the cervical esophagus\n* Carcinoma of the gastro-esophageal junction (GEJ) with the main part of the tumor in the gastric cardia (Siewert type III)\n* Prior thoracic surgery at the right hemithorax or thoracic trauma","ALL","18 Years","90 Years",{"count":79,"type":80},218,"ESTIMATED","INTERVENTIONAL",[83],"NA","BACKGROUND: For patients with esophageal cancer, radical esophagectomy with 2-field lymphadenectomy is the cornerstone of the multimodality treatment with curative intent. Both, conventional minimally invasive esophagectomy (MIE) and robot assisted minimally invasive esophagectomy (RAMIE) were shown to be superior compared to open transthoracic esophagectomy considering postoperative complications. However, no randomized comparison was made until now to compare MIE to RAMIE\n\nOBJECTIVES: The objective is to evaluate the extent of lymph node dissection, efficacy, risks, quality of life and cost-effectiveness of RAMIE as an alternative to MIE as treatment for esophageal adenocarcinoma or adenocarcinoma of the gastroesophageal junction..\n\nMETHODS: This is an investigator-initiated and investigator-driven multicenter randomized controlled parallel-group, superiority trial. All adult patients (age ≥18 and ≤ 90 years) with histologically proven, surgically resectable (cT1-4a, N0-3, M0) adenocarcinoma of the intrathoracic esophagus or adenocarcinoma of the gastroesophageal junction with European Clinical Oncology Group performance status 0, 1 or 2 will be assessed for eligibility and included after obtaining informed consent. Patients (n=218) are randomized at the outpatient department to either RAMIE (n=109) or MIE (n=109). The primary outcome of this study is the total number of resected lymph nodes according to the TIGER classification for esophageal cancer lymphadenectomy.\n\nCONCLUSION: This is the first randomized controlled trial designed to compare RAMIE to MIE as surgical treatment for resectable adenocarcinoma of the intrathoracic esophagus or adenocarcinoma of the gastroesophageal junction in the Western World. If our hypothesis is proven correct, RAMIE will result in a better lymph node dissection compared to conventional MIE. The study started in September 2019. Follow up will be 5 years. Short term results will be analyzed and published after discharge of the last randomized patient.",[86],"Esophageal Adenocarcinoma",[88,27,89,90,91,92],"minimally invasive esophagectomy","MIE","RAMIE","lymph node dissection","lymphadenectomy","2022-05-16",{"date":95,"type":96},"2022-05-17","ACTUAL",{"date":98,"type":96},"2021-01-18",{"date":100,"type":80},"2028-01-19",{"name":5,"class":6},1]