[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651188":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":65,"collaborators":69,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":25,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":25,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":93,"whyStopped":25,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"OR extubation","ACTIVE_COMPARATOR","Extubation in the operating room (OR) at the conclusion of cardiac surgery",[13],"Procedure: OR extubation",{"label":15,"type":16,"description":17,"interventionNames":18},"ICU extubation","PLACEBO_COMPARATOR","Extubation in the intensive care unit (ICU) within 6 hours of leaving the OR",[19],"Procedure: ICU extubation",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Immediate extubation in the operating room (OR) at the conclusion of cardiac surgery",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Extubation in the intensive care unit (ICU) within 6 hours of leaving the operating room after cardiac surgery",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Lauren Gibson, MD","CONTACT","617-726-3030","legibson@mgh.harvard.edu",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Jordan Bloom, MD, MPH","617-643-6058","jpbloom@mgh.harvard.edu",[40,58],{"facility":41,"status":25,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Brigham and Women's Hospital","Boston","Massachusetts","02115","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-71.05977,42.35843,{"lat":51,"lon":50},[54],{"name":55,"role":32,"phone":56,"phoneExt":25,"email":57},"Chinyere Archie, MBBS","6034962892","legibson@mgb.org",{"facility":5,"status":25,"city":42,"state":43,"zip":59,"country":45,"countryCode":46,"cosmosGeoPoint":60,"geoPoint":62,"contacts":63},"02141",{"type":48,"coordinates":61},[50,51],{"lat":51,"lon":50},[64],{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Lauren E Gibson","Cardiac anesthesiologist",[70],{"name":41,"class":6},"100651188","randomized-evaluation-of-operating-room-extubation-after-cardiac-surgery-100651188",false,"NCT07757880","Randomized Evaluation of Operating Room Extubation After Cardiac Surgery","Randomized Evaluation of Operating Room Extubation Versus Intensive Care Unit Extubation After Cardiac Surgery","Inclusion Criteria:\n\n* Adults (age 18+) scheduled for elective cardiac surgery requiring cardiopulmonary bypass\n* Low perioperative risk defined as STS Predicted Risk of Mortality (PROM) ≤ 3% based on the latest STS Adult Cardiac Surgery Database (ACSD) Risk Calculator\n* Deemed appropriate for OR extubation preoperatively by the attending cardiac surgeon\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Underlying pulmonary disease requiring use of home supplemental oxygen\n* Pre-capillary pulmonary hypertension (mPAP ≥ 25 mmHg or PVR \\> 2 Wood units) on most recent right heart catheterization for any patient for which there is suspicion for pulmonary hypertension at the time of preoperative evaluation\n* Preoperative right ventricular dysfunction greater than mild on most recent echocardiogram\n* Obstructive sleep apnea with home CPAP or biPAP use or recommended use\n* Neuromuscular disease associated with respiratory muscle weakness including myasthenia gravis, Lambert-Eaton myasthenic syndrome, or muscular dystrophy\n* Airway abnormalities including tracheostomy, history of difficult mask ventilation, history of difficult intubation requiring fiberoptic rescue or multiple (\\>2) attempts, known anatomic abnormalities including limited mouth opening (\\\u003C 3cm), severe micrognathia, tracheal stenosis, or tracheal compression due to mass or goiter\n\nWe will also exclude patients undergoing the following procedures:\n\n* Transplant surgery\n* Pulmonary thromboendarterectomy\n* Implantation of mechanical circulatory support including LVAD, Impella, intra-aortic balloon pump, RVAD, or ECMO","ALL","18 Years",{"count":81,"type":82},120,"ESTIMATED","INTERVENTIONAL",[85],"NA","We are studying whether waking patients up and removing the breathing tube (also known as \"extubation\") in the operating room after cardiac surgery improves postoperative recovery without causing harm.",[88],"Cardiac Surgery",[90,91,92],"Extubation","Cardiac surgery","Cardiac surgery recovery","NOT_YET_RECRUITING","2026-08-06",{"date":96,"type":97},"2026-08-11","ACTUAL",{"date":99,"type":82},"2026-08",{"date":101,"type":82},"2027-03",{"name":5,"class":6},2]