[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652036":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":27,"locations":33,"responsibleParty":47,"collaborators":20,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":20,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":20,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":20,"overallStatus":68,"whyStopped":20,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Yale University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Individuals with OUD","EXPERIMENTAL","Participants will complete five study visits. They will receive neurofeedback at two separate scanning sessions (sessions 2-3). Neurofeedback scans will include rest, neurofeedback, and transfer (i.e., no feedback) runs, one week apart.",[13],"Device: real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback","A non-invasive, non-pharmacological therapeutic tool that enables an individual to learn to modulate their neural activity in order to effect behavioral change.",[9],null,[22,25],{"name":23,"affiliation":5,"role":24},"Michelle Hampson, PhD","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":5,"role":24},"Kathleen Garrison, PhD",[28],{"name":29,"role":30,"phone":31,"phoneExt":20,"email":32},"Sarah Paprotna","CONTACT","+1 (203) 737-5994","sarah.paprotna@yale.edu",[34],{"facility":35,"status":20,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":20},"APT Foundation","New Haven","Connecticut","06520","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-72.92816,41.30815,{"lat":45,"lon":44},{"type":48,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100652036","real-time-opioid-study-100652036",false,"NCT07768007","Real-time Opioid Study","Neurofeedback in Individuals With Substance Use Disorders","Inclusion Criteria:\n\n* ≥3 months of methadone treatment for OUD\n* Presence of anhedonia, as assessed via SHAPS\n* Baseline autobiographical memory deficit, as assessed via AMT\n\nExclusion Criteria:\n\n* Failure to pass an MRI screening\n* Women who are pregnant\n* Psychosis, as assessed via Yale PRIME Early Psychosis Screening Test\n* Serious suicidal ideation\n* Serious medical condition\n* Legally blind","ALL","18 Years","50 Years",{"count":60,"type":61},3,"ESTIMATED","INTERVENTIONAL",[64],"NA","This feasibility study collects initial data on the use of an fMRI neurofeedback protocol for treating anhedonia in methadone-treated individuals with opioid use disorder (OUD). The intervention tested has previously been shown to reduce anhedonia in individuals with depression and this study is collecting first-in-human data in an OUD population. Investigators will assess tolerability of the intervention and collect preliminary data from 2-3 subjects monitoring changes in anhedonia, non-substance-related autobiographical memory recall, and meaning in life.",[67],"Substance Use Disorder (SUD)","NOT_YET_RECRUITING","2026-08-11",{"date":71,"type":72},"2026-08-17","ACTUAL",{"date":74,"type":61},"2026-08",{"date":76,"type":61},"2027-02",{"name":5,"class":6},1]