[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659983":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":17,"overallOfficials":27,"centralContacts":32,"locations":42,"responsibleParty":314,"collaborators":316,"id":319,"slug":320,"hasResults":321,"nctId":322,"briefTitle":323,"officialTitle":323,"acronym":17,"eligibilityCriteria":324,"healthyVolunteers":321,"sex":325,"minAge":326,"maxAge":17,"enrollmentInfo":327,"targetDuration":330,"studyType":331,"phases":17,"briefSummary":332,"conditions":333,"keywords":335,"overallStatus":340,"whyStopped":17,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":350},{"fullName":5,"class":6},"Mundipharma (China) Pharmaceutical Co. Ltd","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"The proportion of participants achieving pain relief after treatment.","Pain assessments will be performed using the BPI-SF (Brief Pain Inventory-Short Form) and NRS (Numerical Rating Scale).\n\nThe proportion of participants achieving pain remission, which is defined as the rate of participants with average NRS (Numerical rating scale) score ≤3 \\[CR (Complete remission)\\] or achieving a reduction of 25% when NRS score \\>3 \\[PR (Partial remission)\\] at 72 h","From enrollment to the end of follow-up at Day 8.",[14],{"measure":15,"description":16,"timeFrame":12},"Adverse events: the frequency and severity of adverse events","assessed primarily by adverse events occurring after treatment (defined as adverse events that emerge or worsen following the first dose of OxyContin), and may also be evaluated via physical examinations and vital signs.",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"COHORT","PROSPECTIVE","Primary Endpoints: The proportion of participants achieving pain remission, which is defined as the rate of participants with average NRS (Numerical rating scale) score ≤3 \\[CR (Complete remission)\\] or achieving a reduction of 25% when NRS score \\>3 \\[PR (Partial remission)\\] at 72 h.\n\nSecondary Endpoints:\n\n* The proportions of participants with CR and PR at 24h and 48h\n* Time-to-first CR and PR\n* The respective proportions of participants with no rescue medication use at 24h, 48h, and 72h\n* Pain severity subscale score, interference of pain subscale score from the BPI-SF\n* The average titration dosage of OxyContin\n* The average maintenance dosage of OxyContin\n* Adverse events: the frequency and severity of adverse event","Adult patients with moderate-to-severe cancer pain treated with the outpatient OxyContin dose titration regimen，able to complete questionnaire and scale assessments.",[24],{"label":25,"type":17,"description":26,"interventionNames":17},"Outpatient OxyContin Dose Titration for Patients with Moderate-to-Severe Cancer Pain","Outpatient OxyContin Dose Titration for Patients with Moderate-to-Severe Cancer Pain，This study is a multi-center prospective single arm real-world study with OxyContin as background titration. The study consists of 2 phases: Screening\u002F titration phase and maintenance phase.",[28],{"name":29,"affiliation":30,"role":31},"Minghua Cong, MD","Cancer Institute and Hospital, Chinese Academy of Medical Sciences","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":17,"email":37},"Gang Peng","CONTACT","+86 13699158703","Gang.Peng@mundipharma.com.cn",{"name":39,"role":35,"phone":40,"phoneExt":17,"email":41},"Xu Chen","+86 18019947155","xu.chen@tigermedgrp.com",[43,60,74,88,102,116,130,144,158,172,183,197,205,219,230,244,258,272,286,300],{"facility":44,"status":17,"city":45,"state":17,"zip":17,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Cancer Hospital Chinese Academy of Medical Scienc","Beijing","China","CN",{"type":49,"coordinates":50},"Point",[51,52],116.39723,39.9075,{"lat":52,"lon":51},[55,59],{"name":56,"role":35,"phone":57,"phoneExt":17,"email":58},"Minghua Cong","+86 150 0104 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Institute)","Shenyang",{"type":49,"coordinates":248},[249,250],123.43278,41.79222,{"lat":250,"lon":249},[253,257],{"name":254,"role":35,"phone":255,"phoneExt":17,"email":256},"Wenyao Cui","+86 18509860120","wenyaoc@163.com",{"name":254,"role":31,"phone":17,"phoneExt":17,"email":17},{"facility":259,"status":17,"city":260,"state":17,"zip":17,"country":46,"countryCode":47,"cosmosGeoPoint":261,"geoPoint":265,"contacts":266},"Shenzhen Second People's Hospital","Shenzhen",{"type":49,"coordinates":262},[263,264],114.0683,22.54554,{"lat":264,"lon":263},[267,271],{"name":268,"role":35,"phone":269,"phoneExt":17,"email":270},"Geng Tian","+86 13724395569","tiangeng666@aliyun.com",{"name":268,"role":31,"phone":17,"phoneExt":17,"email":17},{"facility":273,"status":17,"city":274,"state":17,"zip":17,"country":46,"countryCode":47,"cosmosGeoPoint":275,"geoPoint":279,"contacts":280},"The Second Hospital of Hebei Medical University","Shijiazhuang",{"type":49,"coordinates":276},[277,278],114.47861,38.04139,{"lat":278,"lon":277},[281,285],{"name":282,"role":35,"phone":283,"phoneExt":17,"email":284},"Guangzhao Liu","+86 15803210979","liuguangzhao100@sina.com",{"name":282,"role":31,"phone":17,"phoneExt":17,"email":17},{"facility":287,"status":17,"city":288,"state":17,"zip":17,"country":46,"countryCode":47,"cosmosGeoPoint":289,"geoPoint":293,"contacts":294},"Shaanxi Cancer Hospital","Xi'an",{"type":49,"coordinates":290},[291,292],108.92861,34.25833,{"lat":292,"lon":291},[295,299],{"name":296,"role":35,"phone":297,"phoneExt":17,"email":298},"Xiaoquan Chen","+86 13186141921","2435350357@qq.com",{"name":296,"role":31,"phone":17,"phoneExt":17,"email":17},{"facility":301,"status":17,"city":302,"state":17,"zip":17,"country":46,"countryCode":47,"cosmosGeoPoint":303,"geoPoint":307,"contacts":308},"Henan Cancer Hospital","Zhengzhou",{"type":49,"coordinates":304},[305,306],113.64861,34.75778,{"lat":306,"lon":305},[309,313],{"name":310,"role":35,"phone":311,"phoneExt":17,"email":312},"Guanglun Xie","+86 13939029792","xieguanglun@126.com",{"name":310,"role":31,"phone":17,"phoneExt":17,"email":17},{"type":315,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR",[317],{"name":318,"class":6},"Tigermed Consulting Co., Ltd","100659983","real-world-study-of-the-effectiveness-and-tolerability-of-outpatient-titration-of-oxycontin-for-the-moderate-and-severe-pain-in-cancer-patients-100659983",false,"NCT07869797","Real-world Study of the Effectiveness and Tolerability of Outpatient Titration of OxyContin for the Moderate and Severe Pain in Cancer Patients","Inclusion Criteria:\n\n* Male or female cancer participants, age ≥ 18 years\n* Participants presenting with moderate to severe (NRS ≥ 4 points) cancer-related pain\n* Participants undergoing outpatient titration regimen with OxyContin as background, see Appendix 3\n* Voluntarily sign an informed consent form\n\nExclusion Criteria:\n\n* Participants with cognitive impairment, delirium, psychiatric disorders, or other conditions that may interfere with reliable pain self-assessment\n* Participants are receiving surgery or minimally invasive interventional pain management\n* Participants are not willing to cooperate in completing follow-up\n* The investigator judges as unsuitable for inclusion in the study","ALL","18 Years",{"count":328,"type":329},378,"ESTIMATED","8 Days","OBSERVATIONAL","The purpose of this observational study is to evaluate the effectiveness and tolerability of outpatient titration regimen with OxyContin as background for moderate and severe pain in cancer patients in adult patients with moderate to severe cancer pain. The main questions it aims to answer are\n\n* To evaluate the effectiveness of titration regimen with OxyContin as background for the moderate and severe pain in cancer participants\n* To explore the tolerability of titration regimen with OxyContin as background use in outpatient participants with moderate and severe cancer pain",[334],"Cancer Pain",[336,337,338,339],"moderate and severe pain in cancer patients","outpatient titration of OxyContin","Real-world study","effectiveness and tolerability","NOT_YET_RECRUITING","2026-10-07",{"date":343,"type":344},"2026-10-13","ACTUAL",{"date":346,"type":329},"2026-10",{"date":348,"type":329},"2027-04",{"name":5,"class":6},20]