[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590450":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":45,"collaborators":20,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":20,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Open or laparoscopic TG followed by JP reconstruction.","EXPERIMENTAL","All participants will undergo open or laparoscopic Total Gastrectomy (TG) followed by Jejunal Pouch (JP) reconstruction.",[13],"Procedure: Jejunal Pouch reconstruction.",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Jejunal Pouch reconstruction.","The JP will be fashioned with a standard length of 12 cm using two 60 mm staple lines, the esophago-pouch anastomosis will be performed with a circular mechanical 25 mm stapling device, and finally the staple entrance on the pouch will be closed with two layers of running sutures in Vicryl 3\u002F0",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Annamaria Agnes, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","+39 0630167190","annamaria.agnes@policlinicogemelli.it",[31],{"facility":32,"status":33,"city":34,"state":20,"zip":20,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Fondazione Policlinico Universitario A. Gemelli IRCCS","RECRUITING","Roma","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],11.10642,44.99364,{"lat":41,"lon":40},[44],{"name":23,"role":27,"phone":20,"phoneExt":20,"email":29},{"type":46,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100590450","reconstruction-with-a-lawrence-hunt-jejunal-pouch-after-total-gastrectomy-100590450",false,"NCT06967571","Reconstruction With a Lawrence-Hunt Jejunal Pouch After Total Gastrectomy","Reconstruction With a Lawrence-Hunt Jejunal Pouch for Upfront Total Gastrectomy - Study Protocol of a Prospective, Single-arm, Phase II Trial","REJOY","Inclusion Criteria:\n\n* Adults aged 18-75 years.\n* Histologically confirmed gastric tumor (including adenocarcinoma, gastrointestinal stromal tumor - GIST- or neuroendocrine tumor) or patients with CDH1 mutation, scheduled for TG with a maximal esophageal resection of \\\u003C 6 cm.\n* Informed consent capability.\n\nExclusion Criteria:\n\n* Prior abdominal surgeries affecting the jejunum.\n* Severe comorbidities or non-appropriate organ function: uncontrolled diabetes with HbA1C \\> 7.5, significant heart disease: New York Heart Association (NYHA) functional classification Class III or IV, chronic obstructive pulmonary disease (COPD) requiring oxygen supplementation or continuous positive airway pressure (CPAP), chronic corticosteroid therapy (daily for more than 6 months), neutrophil count \\\u003C 2000\u002Fmm3, hemoglobin \\\u003C 8.0 g\u002FdL, platelet count \\\u003C 100,000\u002Fmm3, serum total bilirubin \\> 1.5 mg\u002FdL, serum aspartate aminotransferase (AST) \\>100 IU\u002FL, serum alanine aminotransferase (ALT) \\>100 IU\u002FL, and creatinine clearance (CCr) ≥ 50 mL\u002Fmin), ECOG performance status \\> 1.\n* Pregnancy or breastfeeding.","ALL","18 Years","75 Years",{"count":59,"type":60},26,"ESTIMATED","INTERVENTIONAL",[63],"NA","The aim of the study is to establish the efficacy of jejunal pouch reconstruction in reducing dumping syndrome in patients undergoing total gastrectomy, ultimately enhancing postoperative quality of life and nutritional status.",[66,67],"Total Gastrectomy","Gastric Cancer",[69,70],"gastric cancer","total gastrectomy","2026-07-22",{"date":73,"type":74},"2026-07-23","ACTUAL",{"date":76,"type":74},"2026-01-01",{"date":78,"type":60},"2028-04-01",{"name":5,"class":6},1]