[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651762":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":15,"collaborators":10,"id":19,"slug":20,"hasResults":21,"nctId":22,"briefTitle":23,"officialTitle":24,"acronym":10,"eligibilityCriteria":25,"healthyVolunteers":21,"sex":26,"minAge":27,"maxAge":28,"enrollmentInfo":29,"targetDuration":10,"studyType":32,"phases":10,"briefSummary":33,"conditions":34,"keywords":38,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Toddlers (3-6 years)",null,"Pediatric patients aged 3 to 6 years undergoing elective surgery under general anesthesia. This cohort receives a standardized propofol-based total intravenous anesthesia (TIVA) protocol, which includes induction with propofol (2-3 mg\u002Fkg IV) and maintenance via continuous infusion utilizing Kataria model predictions.",{"label":13,"type":10,"description":14,"interventionNames":10},"Older Children (6-12 years)","Pediatric patients aged 6 to 12 years undergoing elective surgery under general anesthesia. This cohort receives a standardized propofol-based total intravenous anesthesia (TIVA) protocol, which includes induction with propofol (2-3 mg\u002Fkg IV) and maintenance via continuous infusion utilizing Kataria model predictions.",{"type":16,"investigatorFullName":17,"investigatorTitle":18,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mariam Ashraf Salah Ali","Resident of Anesthesia","100651762","recovery-trajectories-after-propofol-based-intravenous-anesthesia-in-toddlers-and-older-children-100651762",false,"NCT07766629","Recovery Trajectories After Propofol-Based Intravenous Anesthesia in Toddlers and Older Children","Age-Stratified Recovery Trajectories Following Propofol-Based Total Intravenous Anesthesia: A Comparative Study Between Toddlers (3-6 Years) and Older Children (6-12 Years)","Inclusion Criteria:\n\n* Age 3-12 years\n* ASA I-II\n* Elective surgery under general anaesthesia\n* Surgical duration 30-120 minutes\n* Propofol TIVA as the primary anesthetic technique\n\nExclusion Criteria:\n\n* Neurological disorders\n* Developmental delay\n* Hepatic or renal impairment\n* Obesity (\\>95th percentile)\n* Concomitant sedative medications","ALL","3 Years","12 Years",{"count":30,"type":31},64,"ESTIMATED","OBSERVATIONAL","This observational study aims to compare how quickly and smoothly younger children (ages 3 to 6 years) recover from general anesthesia compared to older children (ages 6 to 12 years).\n\nWhile inhalational anesthesia (breathing in anesthetic gases) has traditionally been the standard for pediatric surgeries, total intravenous anesthesia (TIVA) using a short-acting medication called propofol is increasingly being used. Propofol TIVA offers several benefits, including reduced postoperative nausea and vomiting, less airway irritation, a smoother waking process, and an earlier readiness to go home. However, because children's bodies and metabolisms change rapidly as they grow, the way propofol is processed by and clears from the body varies significantly by age.\n\nCurrently, there is limited evidence detailing exactly how these age-related differences affect recovery times. To investigate this, researchers will monitor 64 children undergoing elective surgeries (lasting between 30 and 120 minutes) who receive propofol TIVA as their primary anesthetic.\n\nAfter the procedure, the study will measure the exact time it takes for participants in both age groups to meet specific, standardized safe-discharge criteria (known as Phase II recovery readiness). Researchers will also track several other important recovery factors, including the time it takes for children to open their eyes, pain levels, the occurrence of emergence delirium (agitation or confusion upon waking), and any breathing-related complications. By comparing the recovery trajectories of toddlers and older children, this research seeks to improve postoperative care planning and provide clearer expectations for pediatric intravenous anesthesia.",[35,36,37],"Anesthesia Recovery","Pediatric Anesthesia","Total Intravenous Anesthesia",[39,40,41,42,43],"Propofol","TIVA","Emergence Delirium","Postoperative Nausea and Vomiting","PAED Scale","NOT_YET_RECRUITING","2026-08-11",{"date":47,"type":48},"2026-08-14","ACTUAL",{"date":50,"type":31},"2026-09",{"date":52,"type":31},"2027-10",{"name":5,"class":6}]