[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646422":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":12,"collaborators":10,"id":16,"slug":17,"hasResults":18,"nctId":19,"briefTitle":20,"officialTitle":21,"acronym":10,"eligibilityCriteria":22,"healthyVolunteers":18,"sex":23,"minAge":24,"maxAge":10,"enrollmentInfo":25,"targetDuration":10,"studyType":28,"phases":10,"briefSummary":29,"conditions":30,"keywords":34,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"AECOPD Patients",null,"Adult patients (over 18 years of age) admitted to the Chest Diseases and Tuberculosis department with an Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). Participants will undergo routine clinical and laboratory assessments, including complete blood counts to evaluate red blood cell and platelet indices, arterial blood gases, pulmonary function tests (PFTs), and high-resolution computed tomography (HRCT) to predict disease severity and clinical outcomes.",{"type":13,"investigatorFullName":14,"investigatorTitle":15,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Maha Elsayed Allam","Resident at Chest Diseases Department","100646422","red-blood-cell-and-platelet-indices-for-predicting-outcomes-in-acute-exacerbations-of-copd-100646422",false,"NCT07693127","Red Blood Cell and Platelet Indices for Predicting Outcomes in Acute Exacerbations of COPD","Assessment of Red Blood Cell and Platelet Indices in Predicting Outcome in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n* Patients above 18 years admitted to the department with AECOPD defined as an event characterized by increased dyspnea and\u002For cough and sputum that worsens in ≤14 days.\n\nExclusion Criteria:\n\n* Primary reason for admission other than AECOPD.\n* The patient has a diagnosis of connective tissue disorder, inflammatory bowel disease, or hematological system diseases (such as malignancy, thalassemia, hemolytic anemia).","ALL","18 Years",{"count":26,"type":27},50,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to evaluate if standard, easily accessible blood tests can help doctors predict the severity and outcomes of sudden flare-ups in patients with Chronic Obstructive Pulmonary Disease (COPD).\n\nWhen a patient's COPD suddenly worsens, an event called an acute exacerbation, it can lead to serious health complications, breathing difficulties, and hospitalization. Currently, doctors need simple and cost-effective ways to figure out early on which patients are at the highest risk for severe complications.\n\nThis observational study will focus on specific components of a routine Complete Blood Count (CBC) test. Researchers will look at the size, volume, and variation of red blood cells (such as Red Cell Distribution Width, or RDW) and platelets. Both red blood cells and platelets are known to be affected by the body's systemic inflammatory response during a severe COPD flare-up.\n\nParticipants will include adults over 18 years old who are admitted to the hospital for an acute exacerbation of COPD. As part of the study, researchers will collect and analyze routine clinical data, including:\n\n* Medical history and physical examination findings (including dyspnea severity).\n* Standard laboratory blood tests (evaluating red blood cells, platelets, kidney and liver function, and inflammation markers).\n* Arterial blood gas levels.\n* Pulmonary function tests (breathing tests to measure lung capacity).\n* High-resolution computed tomography (HRCT) chest scans.\n\nBy analyzing this information, the study aims to determine if red blood cell and platelet indices can accurately predict important clinical outcomes. These outcomes include the need for Intensive Care Unit (ICU) admission, the need for a mechanical ventilator (breathing machine), the total length of the hospital stay, and in-hospital mortality. Identifying reliable biomarkers could help healthcare providers make faster, more targeted treatment decisions for COPD patients.",[31,32,33],"Acute Exacerbation of Chronic Obstructive Pulmonary Disease","Chronic Obstructive Pulmonary Disease (COPD)","AECOPD",[35,36,37,38,39,40,41,42],"Red Blood Cell Indices","Platelet Indices","Red Cell Distribution Width (RDW)","Mean Platelet Volume (MPV)","Platelet Distribution Width (PDW)","Biomarkers","Prognosis","Systemic Inflammation","NOT_YET_RECRUITING","2026-07-03",{"date":46,"type":47},"2026-07-09","ACTUAL",{"date":49,"type":27},"2026-08",{"date":51,"type":27},"2027-09",{"name":5,"class":6}]