[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630208":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":37,"studyPopulation":29,"armGroups":38,"interventions":51,"overallOfficials":29,"centralContacts":61,"locations":67,"responsibleParty":106,"collaborators":109,"id":113,"slug":114,"hasResults":115,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":115,"sex":121,"minAge":122,"maxAge":29,"enrollmentInfo":123,"targetDuration":29,"studyType":126,"phases":127,"briefSummary":129,"conditions":130,"keywords":133,"overallStatus":70,"whyStopped":29,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":149},{"fullName":5,"class":6},"Universidad Catolica Santiago de Guayaquil","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Mean change in horizontal alveolar ridge width (mm) measured by cone-beam computed tomography (CBCT)","Horizontal alveolar ridge width will be measured in millimeters using cone-beam computed tomography (CBCT). Measurements will be obtained at three standardized levels (1 mm, 3 mm, and 5 mm below the crestal bone). Baseline and follow-up CBCT scans will be superimposed, and the mean change in ridge width (mm) between time points will be calculated.","Baseline (immediately after ridge preservation surgery) to 6 months after surgery (prior to implant placement)",[14,17,21,25],{"measure":15,"description":16,"timeFrame":12},"Mean change in vertical alveolar bone height (mm) measured by cone-beam computed tomography (CBCT)","Vertical alveolar bone height will be measured in millimeters using CBCT by determining the distance between the crestal bone (line C) and the apical reference line (line A). Baseline and follow-up CBCT scans will be superimposed, and the mean change in vertical bone height will be calculated.",{"measure":18,"description":19,"timeFrame":20},"Mean implant stability quotient (ISQ) measured using resonance frequency analysis (Osstell IDx)","Implant stability will be measured using resonance frequency analysis with the Osstell IDx device. Implant Stability Quotient (ISQ) values will be recorded in mesiodistal and buccolingual directions, and the mean ISQ value will be calculated for each implant.","Implant placement to prosthetic loading (approximately 3 months)",{"measure":22,"description":23,"timeFrame":24},"Mean marginal bone level change (mm) measured on standardized periapical radiographs","Marginal bone levels will be measured using standardized digital periapical radiographs obtained with a parallel technique and individualized film holders. The distance from the implant-abutment junction to the first bone-to-implant contact will be measured mesially and distally, and the mean marginal bone level change will be calculated.","Implant placement to 2 years after prosthetic loading",{"measure":26,"description":27,"timeFrame":28},"Mean postoperative pain score measured using the Visual Analog Scale (VAS, 0-10)","Postoperative pain will be assessed using the Visual Analog Scale ranging from 0 (no pain) to 10 (worst imaginable pain). The mean pain score will be calculated.","24 hours to 14 days after implant placement surgery",null,{"allocation":31,"interventionModel":32,"interventionModelDescription":33,"primaryPurpose":34,"observationalModel":29,"timePerspective":29,"maskingInfo":35},"RANDOMIZED","PARALLEL","Participants will be randomly assigned to two parallel groups: one group receiving treatment with a reduced time interval between phases and a control group receiving treatment according to the conventional interval protocol. Outcomes will be compared between groups.","TREATMENT",{"masking":36,"maskingDescription":29,"whoMasked":29},"NONE","The optimal interval between treatment phases remains uncertain in several clinical settings. Traditional protocols often include a waiting period between phases to allow tissue healing or stabilization; however, prolonged intervals may extend overall treatment time and potentially affect patient adherence and outcomes. Emerging evidence suggests that reducing the interval between phases could maintain clinical effectiveness while improving efficiency and patient satisfaction. This randomized controlled trial will compare a reduced-interval protocol with a conventional-interval protocol. Eligible participants who require multi-phase treatment will be randomized into two groups: (1) reduced-interval treatment and (2) standard-interval treatment. Clinical examinations will be conducted at baseline and at scheduled follow-up visits according to the study protocol.\n\nPrimary outcomes will assess clinically relevant parameters associated with the treated condition. Secondary outcomes will evaluate treatment duration, patient-reported symptoms, and quality-of-life measures. Statistical analyses will compare outcomes between groups to determine whether the reduced-interval approach provides equivalent or improved results compared with the conventional schedule.",[39,45],{"label":40,"type":41,"description":42,"interventionNames":43},"Reduced time Interval treatment protocol","EXPERIMENTAL","Participants receive implant placement after extraction socket preservation using a reduced healing interval according to the experimental protocol.",[44],"Procedure: Reduced time interval treatment protocol",{"label":46,"type":47,"description":48,"interventionNames":49},"Standard Time Interval","ACTIVE_COMPARATOR","Participants receive treatment following the conventional interval protocol used in routine clinical practice.",[50],"Procedure: Standard time interval treatment protocol",[52,57],{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":29},"PROCEDURE","Reduced time interval treatment protocol","Participants receive treatment phases with a reduced time interval between sessions according to the experimental protocol in order to evaluate whether shortening the interval improves clinical outcomes and treatment efficiency.",[40],{"type":53,"name":58,"description":59,"armGroupLabels":60,"otherNames":29},"Standard time interval treatment protocol","Participants receive implant placement after extraction socket preservation following the conventional healing interval used in routine clinical practice.",[46],[62],{"name":63,"role":64,"phone":65,"phoneExt":29,"email":66},"GABRIELA GUADALUPE ZAMBRANO MANZABA, DDS","CONTACT","+19546298543","gabriela.manzaba30@gmail.com",[68],{"facility":69,"status":70,"city":71,"state":72,"zip":73,"country":74,"countryCode":75,"cosmosGeoPoint":76,"geoPoint":81,"contacts":82},"Universidad Catolica Santiago de Guayaquil- Carrera de Odontologia de La Ucsg","RECRUITING","Guayaquil","Guayas","090101","Ecuador","EC",{"type":77,"coordinates":78},"Point",[79,80],-79.88621,-2.19616,{"lat":80,"lon":79},[83,85,88,91,94,96,98,100,102,104],{"name":63,"role":64,"phone":84,"phoneExt":29,"email":66},"+1 9546298543",{"name":86,"role":64,"phone":87,"phoneExt":29,"email":66},"GABRIELA ZAMBRANO MANZABA, DDS","9546298543",{"name":89,"role":90,"phone":29,"phoneExt":29,"email":29},"GABRIELA G ZAMBRANO MANZABA, DDS","PRINCIPAL_INVESTIGATOR",{"name":92,"role":93,"phone":29,"phoneExt":29,"email":29},"MANUEL TOLEDANO PEREZ, DDS","SUB_INVESTIGATOR",{"name":95,"role":93,"phone":29,"phoneExt":29,"email":29},"RAQUEL OSORIO RUIZ, DDS",{"name":97,"role":93,"phone":29,"phoneExt":29,"email":29},"MANUEL TOLEDANO OSORIO, DDS",{"name":99,"role":93,"phone":29,"phoneExt":29,"email":29},"MARIA C VALLECILLO, DDS",{"name":101,"role":93,"phone":29,"phoneExt":29,"email":29},"JAVIER GIL, DDS",{"name":103,"role":93,"phone":29,"phoneExt":29,"email":29},"HECTOR A LEMA GUTIERREZ, DDS",{"name":105,"role":93,"phone":29,"phoneExt":29,"email":29},"ALEJANDRA TORRES SOSA, DDM",{"type":90,"investigatorFullName":107,"investigatorTitle":108,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Gabriela Guadalupe Zambrano Manzaba","Specialist in Periodontology",[110],{"name":111,"class":112},"Klockner Implant System","UNKNOWN","100630208","reduced-time-interval-for-implant-placement-after-extraction-socket-preservation-using-the-vega-plus-implants-100630208",false,"NCT07484685","Reduced Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implants","Effect of Reducing the Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implant System (Klockner): A Randomized Controlled Clinical Trial","RIP-VEGA","Inclusion Criteria:\n\n* Age: ≥ 18 years.\n* Good general health.\n* Need of extraction of incisors, canines or premolars due to carious lesion, endodontic complication, root fracture or prosthetic reason.\n* Presence of three intact socket walls after tooth extraction with a defect of 50% or more of the buccal wall.\n* Need of single-tooth implant treatment, with presence of adjacent teeth and opposing occluding teeth (for measurement stent indexing).\n* Enough available bone assessed on CBCT to place implants with 3.6 mm diameter and 10 mm in length.\n* Periodontal health in intact or reduced periodontium.\n* Full-mouth plaque and bleeding scores \\\u003C 20%.\n* Able and willing to follow study procedures and instructions.\n\nExclusion Criteria:\n\n* \\\u003C 18 years.\n* Compromised health. Existence of any systemic condition such as uncontrolled diabetes mellitus, cancer, HIV, disorders that compromise wound healing, chronic high dose steroid therapy, intravenous and oral bisphosphonate therapy, bone metabolic diseases, history of irradiation of the head and neck area, or any other immunosuppressive therapy that would contraindicate oral surgical treatment.\n* Absence of any adjacent teeth or the opposing occluding teeth.\n* The hopeless tooth is a molar.","ALL","18 Years",{"count":124,"type":125},40,"ESTIMATED","INTERVENTIONAL",[128],"NA","This randomized controlled clinical trial aims to evaluate whether reducing the healing interval for implant placement after extraction socket preservation improves clinical and radiographic outcomes compared with the conventional waiting period. Participants requiring single-tooth extraction and implant therapy will be randomly assigned to implant placement either 4 months or 6 months after ridge preservation using the Vega Plus implant system (Klockner).\n\nClinical and radiographic assessments will be performed at baseline and during follow-up visits. The primary outcome will be the mean change in horizontal alveolar ridge width measured using cone-beam computed tomography (CBCT). Secondary outcomes will include vertical bone height changes measured on CBCT, implant stability measured using resonance frequency analysis (ISQ values), marginal bone level changes assessed on standardized periapical radiographs, and postoperative pain assessed using the Visual Analog Scale (VAS).\n\nThe results of this study may contribute to optimizing treatment timing and improving efficiency in implant dentistry while maintaining favorable clinical outcomes.",[131,132],"Alveolar Bone Loss","Tooth Extraction",[134,135,136,137,138,139],"Dental implant","Tooth extraction","Alveolar ridge preservation","Guided Bone Regeneration","Bone regeneration","Dental Implant Placement","2026-04-27",{"date":142,"type":143},"2026-05-01","ACTUAL",{"date":145,"type":143},"2026-02-28",{"date":147,"type":125},"2027-02-27",{"name":5,"class":6},1]