[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651115":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":30,"responsibleParty":48,"collaborators":52,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":19,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":77,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Lighting intervention","EXPERIMENTAL","Pupillometry at MGH following by saliva collection during one night of dim light and then one night of bright light",[13],"Other: Ocular light exposure from portable light box",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Ocular light exposure from portable light box","One night of dim light exposure and one night of bright light exposure. Lighting from the portable light box",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Elizabeth Klerman, MD PhD","MGB","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":19,"email":29},"CONTACT","617-643-2424","MGB_OSCAR@mgb.org",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"MassGeneralBrigham","RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-71.05977,42.35843,{"lat":43,"lon":42},[46],{"name":22,"role":27,"phone":28,"phoneExt":19,"email":47},"MGH_OSCAR@MGH.HARVARD.EDU",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"SPONSOR_INVESTIGATOR","Elizabeth B Klerman MD PhD","Professor of Neurology",[53],{"name":5,"class":6},"100651115","relationships-among-pupil-responses-to-light-circadian-rhythms-and-sleep-100651115",false,"NCT07753889","Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep","Documenting Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep in Healthy People and Those With Disorders or Disease","SCOPE","Inclusion Criteria:\n\n* 18-85 years old.\n* stable medically\n* ability to speak, understand and read English at a high school level\n\nExclusion Criteria:\n\n* any history of eye trauma or surgery besides correctable vision abnormalities (e.g., with glasses); any abnormalities on clinical eye exam (e.g., neuritis, Neuromyelitis optica, untreated glaucoma) such that the ophthalmologist recommends the participant not be studied;\n* prescription or non-prescription drugs affecting the pupil (e.g., affecting autonomic function), sleep, melatonin (e.g., lithium, alpha- and beta-adrenergic antagonists), and\u002For circadian rhythms (e.g., beta blockers, non-steroidal anti-inflammatory drugs, tricyclics\\\\\n* shift- or night-work in past three months;\n* crossing more than 2 time zones in past three months;\n* pregnant or less than 6 months post-partum or breastfeeding.",true,"ALL","18 Years","85 Years",{"count":67,"type":68},100,"ESTIMATED","INTERVENTIONAL",[71],"NA","The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or illnesses.\n\nAll participants will:\n\n* Answer questionnaires about their health\n* Receive an eye exam,\n* For one week at home, participants will track their sleep and wake using actigraphy (wrist worn wearable) and an online sleep diary.\n* Complete a pupillometry session (measuring pupil size in response to different lighting) at MGH\n\nParticipants may also choose to participate in the following additional procedures in any order:\n\n* Within one week of their pupillometry session, an at-home saliva collection under dim light. Saliva melatonin can be analyzed to determine Dim-Light-Melatonin-Onset (DLMO), a marker of circadian timing.\n* If participants participate in one night saliva collection, a second night of at-home saliva collection with a bright light exposure to calculate melatonin suppression in response to light.",[74,75,76],"Circadian Rhythm","Pupillometry","Sleep",[78,79,80,76],"Pupil (eye)","Light","Circadian Rhythms","2026-08-06",{"date":83,"type":84},"2026-08-10","ACTUAL",{"date":86,"type":68},"2026-09-01",{"date":88,"type":68},"2035-12",{"name":50,"class":6},1]