[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650457":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":36,"collaborators":10,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":10,"eligibilityCriteria":44,"healthyVolunteers":40,"sex":45,"minAge":46,"maxAge":10,"enrollmentInfo":47,"targetDuration":10,"studyType":50,"phases":10,"briefSummary":51,"conditions":52,"keywords":57,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Second Affiliated Hospital, Zhejiang University, School of Medicine","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1: Remimazolam group (RM)",null,"Elderly patients who receive remimazolam as the benzodiazepine sedative during general anesthesia induction (final dose and sequence determined individually by the attending anesthesiologist).",{"label":13,"type":10,"description":14,"interventionNames":10},"Cohort 2: Midazolam group (MZ)","Elderly patients who receive midazolam as the benzodiazepine sedative during general anesthesia induction (final dose and sequence determined individually by the attending anesthesiologist).",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"min Yan, doctor","CONTACT","+86 13757118632","zryanmin@zju.edu.cn",[22],{"facility":23,"status":24,"city":25,"state":10,"zip":10,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"The Second Affiliated Hospital of Zhejiang University School of Medicin","RECRUITING","Hangzhou","China","CN",{"type":29,"coordinates":30},"Point",[31,32],120.16142,30.29365,{"lat":32,"lon":31},[35],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":37,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100650457","remimazolam-versus-midazolam-for-general-anesthesia-induction-in-elderly-patients-undergoing-non-cardiac-surgery-100650457",false,"NCT07746505","Remimazolam Versus Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery","Effectiveness and Safety of Remimazolam Compared With Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n1. Age 65 years or older.\n2. Scheduled for elective non-cardiac surgery under general anesthesia.\n3. American Society of Anesthesiologists physical status I to IV.\n4. Planned airway management with tracheal intubation or a laryngeal mask airway.\n5. Written informed consent provided by the participant or the participant's legally authorized representative.\n\n   \\-\n\nExclusion Criteria:\n\n1. Long-term preoperative benzodiazepine use.\n2. Known allergy or contraindication to benzodiazepines, flumazenil, opioids, naloxone, or related drugs.\n3. History of drug abuse or alcoholism within the past 2 years.\n4. No preoperative cognitive assessment available.\n5. Preoperative cognitive impairment, defined as a Mini-Mental State 6.Examination score less than 18.\n\n7.Refusal to provide informed consent.\n\n\\-","ALL","65 Years",{"count":48,"type":49},1000,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study evaluates the effectiveness and safety of two benzodiazepine sedatives-remimazolam and midazolam-used for general anesthesia induction in elderly patients (≥65 years) undergoing elective non-cardiac surgery. Elderly patients have reduced organ reserve and altered pharmacokinetics\u002Fpharmacodynamics, increasing their susceptibility to anesthesia-related complications such as intraoperative hypotension, delayed emergence, and postoperative delirium. Remimazolam, an ultra-short-acting benzodiazepine metabolized by organ-independent tissue esterases, is hypothesized to offer greater hemodynamic stability, faster recovery, and a more favorable safety profile than midazolam in this vulnerable population. Investigators prospectively observe and collect data without altering routine clinical care; the choice of sedative is made by the attending anesthesiologist according to standard practice. Propensity score methods will be used to reduce confounding by indication.",[53,54,55,56],"General Anesthesia","Aged","Intraoperative Hypotension","Anxiety",[58,59,60,61,62,63,64],"Remimazolam","Midazolam","Elderly","Non-cardiac surgery","Anesthesia induction","Hemodynamic stability","Quality of recovery","2026-08-03",{"date":67,"type":68},"2026-08-05","ACTUAL",{"date":70,"type":68},"2026-06-15",{"date":72,"type":49},"2027-07-15",{"name":5,"class":6},1]