[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647540":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":40,"locations":46,"responsibleParty":59,"collaborators":31,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":31,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":49,"whyStopped":31,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Mansoura University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"nano-eggshell varnish group 1","EXPERIMENTAL","Nano-eggshell varnish will be professionally applied to the teeth surfaces every 3 months according to the manufacturer's instructions. Participants will be instructed to avoid eating or drinking for at least 30 minutes after application.",[13],"Drug: nano-eggshell varnish",{"label":15,"type":10,"description":16,"interventionNames":17},"Casein phosphopeptide amorphous calcium phosphate (CPP-ACP) as GC tooth mousse group 2","Participants will be instructed to apply CPP-ACP (GC tooth mousse) daily after tooth brushing at bedtime. The material will be kept on the tooth surfaces for at least 3 minutes before rinsing.",[18],"Drug: Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP)Dental Paste",{"label":20,"type":21,"description":22,"interventionNames":23},"Sodium fluoride varnish (5%) group 3","ACTIVE_COMPARATOR","Sodium fluoride varnish (5%) will be professionally applied every 3 months according to manufacturer instructions. Participants will be instructed to avoid eating or drinking for at least 30 minutes after application.",[24],"Drug: Sodium Fluoride Varnish (5%)",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","nano-eggshell varnish","Nano-eggshell varnish is applied topically to tooth surfaces every 3 months, according to manufacturer instructions, to promote the remineralization of initial enamel caries.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP)Dental Paste","Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste was applied daily by participants after tooth brushing at bedtime and left on teeth for at least 3 minutes before rinsing.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Sodium Fluoride Varnish (5%)","5% sodium fluoride varnish is applied topically every 3 months according to manufacturer instructions as a controlled remineralizing agent.",[20],[41],{"name":42,"role":43,"phone":44,"phoneExt":31,"email":45},"Ghada E Elhindawy","CONTACT","00201102668577","ghada.ezzat91@yahoo.com",[47],{"facility":48,"status":49,"city":50,"state":31,"zip":31,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":31},"Faculty of Dentistry, Mansoura University","RECRUITING","Al Mansurah","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],31.38069,31.03637,{"lat":57,"lon":56},{"type":60,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100647540","remineralizing-effect-of-nano-eggshell-casein-phosphopeptide-amorphous-calcium-phosphate-cpp-acp-and-sodium-fluoride-on-initial-enamel-caries-100647540",false,"NCT07711132","Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries","Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries: Randomized Controlled Trial","CPP-ACP","Inclusion Criteria:\n\nPatients' ages should be 15-20 years. Patients should have at least three to four teeth with ICDAS II scores of 1-2. Patients should have moderate-to-high caries risk.\n\nExclusion Criteria:\n\nKnown hypersensitivity to one of the components of the material under study. Systemic disorders or medication interfering with normal salivary flow.","ALL","15 Years","20 Years",{"count":73,"type":74},90,"ESTIMATED","INTERVENTIONAL",[77],"NA","This randomized controlled clinical trial aims to evaluate and compare the remineralizing effect of nano-eggshell varnish, CPP-ACP paste (GC Tooth Mousse), and sodium fluoride varnish on initial enamel caries among adolescents aged 15-20 years.\n\nParticipants will be randomly allocated into three groups. Remineralization and caries activity will be assessed using DIAGNOdent readings, International Caries Classification and Management System (ICCMS) criteria, and the decayed, missed, and filled surfaces (DMFS) index over a 12-month follow-up period.",[80],"Initial Dental Caries",[82,83,84],"Remineralization","Nano eggshell","initial enamel caries","2026-07-14",{"date":87,"type":88},"2026-07-17","ACTUAL",{"date":90,"type":88},"2025-12-20",{"date":92,"type":74},"2026-12-20",{"name":5,"class":6},1]