[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614003":3},{"organization":4,"outcomesModule":7,"designInfo":31,"detailedDescription":11,"studyPopulation":11,"armGroups":38,"interventions":50,"overallOfficials":11,"centralContacts":57,"locations":64,"responsibleParty":337,"collaborators":11,"id":339,"slug":340,"hasResults":341,"nctId":342,"briefTitle":343,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":341,"sex":346,"minAge":347,"maxAge":11,"enrollmentInfo":348,"targetDuration":11,"studyType":351,"phases":352,"briefSummary":354,"conditions":355,"keywords":357,"overallStatus":363,"whyStopped":11,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":373},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"All-cause mortality at day 90 after inclusion",null,"90 days after inclusion",[14,18,21,24,28],{"measure":15,"description":16,"timeFrame":17},"Functional recovery","Number of days alive after discharge at home by day 90","Day 90",{"measure":19,"description":20,"timeFrame":17},"SF-36 (Short Form-36 Health Survey) questionnaire score","Quality of livre is evaluated by SF-36 (Short Form-36 Health Survey) questionnaire at day 90",{"measure":22,"description":11,"timeFrame":23},"Number of days alive without vasopressors","Day 7",{"measure":25,"description":26,"timeFrame":27},"Sepsis-related Organ Failure Assessment (SOFA) score","The severity of multiple organ failure assessed by the Sepsis-related Organ Failure Assessment (SOFA) score","Inclusion and days 1, 3 and 7",{"measure":29,"description":30,"timeFrame":27},"Sepsis-induced immuno-inflammatory responses","Dosage of inflammation biomarkers\n\n* Neutrophils to lymphocytes ratio for all patients\n* In about 100 patients (from two centers) with a biological collection, markers of inflammatory\u002Fimmune response (including cytokines, monocyte HLA-DR (Human Leukocyte Antigen) expression, immature neutrophils)",{"allocation":32,"interventionModel":33,"interventionModelDescription":11,"primaryPurpose":34,"observationalModel":11,"timePerspective":11,"maskingInfo":35},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":36,"maskingDescription":37,"whoMasked":11},"NONE","In the control group, no intervention is performed.",[39,45],{"label":40,"type":41,"description":42,"interventionNames":43},"Remote ischemic conditioning","EXPERIMENTAL","A brachial cuff is positioned around one arm of the patient. Remote ischemic conditioning consists of alternating inflations and deflations of the brachial cuff. Four cycles of ischemic conditioning (5-min brachial cuff inflation at 200 mmHg followed by 5-min cuff deflation) are started as soon as possible after inclusion. The intervention is repeated 12 and 24 hours after inclusion.",[44],"Other: Remote ischemic conditioning",{"label":46,"type":6,"description":47,"interventionNames":48},"Control group","No intervention wil be performed in the control group.",[49],"Other: No intervention",[51,53],{"type":6,"name":40,"description":42,"armGroupLabels":52,"otherNames":11},[40],{"type":6,"name":54,"description":55,"armGroupLabels":56,"otherNames":11},"No intervention","No intervention will be performed in the conrol group",[46],[58],{"name":59,"role":60,"phone":61,"phoneExt":62,"email":63},"Martin COUR, MD","CONTACT","4 72 11 28 52","+33","martin.cour@chu-lyon.fr",[65,80,92,104,116,128,140,152,164,175,184,196,205,217,229,241,253,265,277,289,301,313,325],{"facility":66,"status":11,"city":67,"state":11,"zip":68,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":77},"Service de Réanimation Médicale, Hôpital Jean-Minjoz, CHU de Besançon","Besançon","25030","France","FR",{"type":72,"coordinates":73},"Point",[74,75],6.01815,47.24878,{"lat":75,"lon":74},[78],{"name":79,"role":60,"phone":11,"phoneExt":11,"email":11},"Gaël PITON, MD",{"facility":81,"status":11,"city":82,"state":11,"zip":83,"country":69,"countryCode":70,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Service Réanimation Polyvalente, Centre Hospitalier de Fleyriat","Bourg-en-Bresse","01012",{"type":72,"coordinates":85},[86,87],5.2258,46.20574,{"lat":87,"lon":86},[90],{"name":91,"role":60,"phone":11,"phoneExt":11,"email":11},"François DHELFT, MD",{"facility":93,"status":11,"city":94,"state":11,"zip":95,"country":69,"countryCode":70,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Service de Médecine Intensive- Réanimation, Hôpital Gabriel Montpied, CHU de Clermont-Ferrand","Clermont-Ferrand","63003",{"type":72,"coordinates":97},[98,99],3.08682,45.77969,{"lat":99,"lon":98},[102],{"name":103,"role":60,"phone":11,"phoneExt":11,"email":11},"Maxime DUMESNIL, MD",{"facility":105,"status":11,"city":106,"state":11,"zip":107,"country":69,"countryCode":70,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Service de Médecine Intensive-Réanimation, Hôpital Henri Mondor, Assistance Publique des Hôpitaux de Paris","Créteil","94000",{"type":72,"coordinates":109},[110,111],2.46569,48.79266,{"lat":111,"lon":110},[114],{"name":115,"role":60,"phone":11,"phoneExt":11,"email":11},"Armand MEKONTSO-DESSAP, MD",{"facility":117,"status":11,"city":118,"state":11,"zip":119,"country":69,"countryCode":70,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Service de Médecine intensive-Réanimation,Hôpital F Mitterrand, CHU de Dijon","Dijon","21079",{"type":72,"coordinates":121},[122,123],5.01391,47.31344,{"lat":123,"lon":122},[126],{"name":127,"role":60,"phone":11,"phoneExt":11,"email":11},"Jean-Pierre QUENOT, MD",{"facility":129,"status":11,"city":130,"state":11,"zip":131,"country":69,"countryCode":70,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Service de Médecine intensive-Réanimation,Hôpital Albert Michallon, CHU de Grenoble","La Tronche","38700",{"type":72,"coordinates":133},[134,135],5.74629,45.20507,{"lat":135,"lon":134},[138],{"name":139,"role":60,"phone":11,"phoneExt":11,"email":11},"Carole SCHWEBEL, MD",{"facility":141,"status":11,"city":142,"state":11,"zip":143,"country":69,"countryCode":70,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"Service de Médecine Intensive-Réanimation, Hôpital Bicêtre, Assistance Publique des Hôpitaux de Paris","Le Kremlin-Bicêtre","94270",{"type":72,"coordinates":145},[146,147],2.36073,48.81471,{"lat":147,"lon":146},[150],{"name":151,"role":60,"phone":11,"phoneExt":11,"email":11},"Tai PHAM, MD",{"facility":153,"status":11,"city":154,"state":11,"zip":155,"country":69,"countryCode":70,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"Service de Médecine Intensive-Réanimation, Hôpital Salengro, CHU de Lille","Lille","59037",{"type":72,"coordinates":157},[158,159],3.05512,50.63391,{"lat":159,"lon":158},[162],{"name":163,"role":60,"phone":11,"phoneExt":11,"email":11},"Raphaël FAVORY, MD",{"facility":165,"status":11,"city":166,"state":11,"zip":167,"country":69,"countryCode":70,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon","Lyon","69003",{"type":72,"coordinates":169},[170,171],4.84789,45.74906,{"lat":171,"lon":170},[174],{"name":59,"role":60,"phone":11,"phoneExt":62,"email":11},{"facility":176,"status":11,"city":166,"state":11,"zip":177,"country":69,"countryCode":70,"cosmosGeoPoint":178,"geoPoint":180,"contacts":181},"Service Réanimation Polyvalente, Hôpital Saint-Joseph Saint-Luc","69007",{"type":72,"coordinates":179},[170,171],{"lat":171,"lon":170},[182],{"name":183,"role":60,"phone":11,"phoneExt":11,"email":11},"Emmanuel VIVIER, MD",{"facility":185,"status":11,"city":186,"state":11,"zip":187,"country":69,"countryCode":70,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"Service de Médecine Intensive-Réanimation, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille","Marseille","13015",{"type":72,"coordinates":189},[190,191],5.38107,43.29695,{"lat":191,"lon":190},[194],{"name":195,"role":60,"phone":11,"phoneExt":11,"email":11},"Sami HRAIECH, MD",{"facility":197,"status":11,"city":186,"state":11,"zip":198,"country":69,"countryCode":70,"cosmosGeoPoint":199,"geoPoint":201,"contacts":202},"Service de Réanimation des Urgences, Hôpital de la Timone, CHU de Marseille","13385",{"type":72,"coordinates":200},[190,191],{"lat":191,"lon":190},[203],{"name":204,"role":60,"phone":11,"phoneExt":11,"email":11},"Marc GAINNIER, MD",{"facility":206,"status":11,"city":207,"state":11,"zip":208,"country":69,"countryCode":70,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Service de Médecine intensive-Réanimation, Hôpital Lapeyronie, CHU de Montpellier","Montpellier","34295",{"type":72,"coordinates":210},[211,212],3.87635,43.61093,{"lat":212,"lon":211},[215],{"name":216,"role":60,"phone":11,"phoneExt":11,"email":11},"Kada KLOUCHE, MD",{"facility":218,"status":11,"city":219,"state":11,"zip":220,"country":69,"countryCode":70,"cosmosGeoPoint":221,"geoPoint":225,"contacts":226},"Service de Médecine Intensive-Réanimation, Hôpital Central, CHRU de Nancy","Nancy","54035",{"type":72,"coordinates":222},[223,224],6.18496,48.68439,{"lat":224,"lon":223},[227],{"name":228,"role":60,"phone":11,"phoneExt":11,"email":11},"Sébastien GIBOT, MD",{"facility":230,"status":11,"city":231,"state":11,"zip":232,"country":69,"countryCode":70,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Service de Médecine Intensive-Réanimation, Hôtel Dieu, CHU de Nantes","Nantes","44093",{"type":72,"coordinates":234},[235,236],-1.55336,47.21725,{"lat":236,"lon":235},[239],{"name":240,"role":60,"phone":11,"phoneExt":11,"email":11},"Jean REIGNIER, MD",{"facility":242,"status":11,"city":243,"state":11,"zip":244,"country":69,"countryCode":70,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"Service de Médecine Intensive - Réanimation, Hôpital Cochin, Assistance Publique des Hôpitaux de Paris","Paris","75014",{"type":72,"coordinates":246},[247,248],2.3488,48.85341,{"lat":248,"lon":247},[251],{"name":252,"role":60,"phone":11,"phoneExt":11,"email":11},"Jean-Paul MIRA, MD",{"facility":254,"status":11,"city":255,"state":11,"zip":256,"country":69,"countryCode":70,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"Service d'Anesthésie - Réanimation - Médecine Intensive, Hôpital Lyon Sud, Hospices Civils de Lyon","Pierre-Bénite","69495",{"type":72,"coordinates":258},[259,260],4.82424,45.70359,{"lat":260,"lon":259},[263],{"name":264,"role":60,"phone":11,"phoneExt":11,"email":11},"Auguste DARGENT, MD",{"facility":266,"status":11,"city":267,"state":11,"zip":268,"country":69,"countryCode":70,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Service de Médecine Intensive et Réanimation Polyvalente, Hôpital Robert Debré, CHU Reims","Reims","51090",{"type":72,"coordinates":270},[271,272],4.02853,49.26526,{"lat":272,"lon":271},[275],{"name":276,"role":60,"phone":11,"phoneExt":11,"email":11},"David BUSSY, MD",{"facility":278,"status":11,"city":279,"state":11,"zip":280,"country":69,"countryCode":70,"cosmosGeoPoint":281,"geoPoint":285,"contacts":286},"Service des maladies infectieuses et réanimation médicale, Hôpital Pontchaillou, CHU de Rennes","Rennes","35000",{"type":72,"coordinates":282},[283,284],-1.67431,48.11109,{"lat":284,"lon":283},[287],{"name":288,"role":60,"phone":11,"phoneExt":11,"email":11},"Félicie BELICARD, MD",{"facility":290,"status":11,"city":291,"state":11,"zip":292,"country":69,"countryCode":70,"cosmosGeoPoint":293,"geoPoint":297,"contacts":298},"Service Réanimation Polyvalente, Centre Hospitalier de Roanne","Roanne","42328",{"type":72,"coordinates":294},[295,296],4.06802,46.03624,{"lat":296,"lon":295},[299],{"name":300,"role":60,"phone":11,"phoneExt":11,"email":11},"Pascal BEURET, MD",{"facility":302,"status":11,"city":303,"state":11,"zip":304,"country":69,"countryCode":70,"cosmosGeoPoint":305,"geoPoint":309,"contacts":310},"Service de Médecine intensive-Réanimation, Hôpital Nord, CHU de St Etienne","Saint-Priest-en-Jarez","42270",{"type":72,"coordinates":306},[307,308],4.37678,45.4739,{"lat":308,"lon":307},[311],{"name":312,"role":60,"phone":11,"phoneExt":11,"email":11},"Sophie PERINEL, MD",{"facility":314,"status":11,"city":315,"state":11,"zip":316,"country":69,"countryCode":70,"cosmosGeoPoint":317,"geoPoint":321,"contacts":322},"Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, CHU de Strasbourg","Strasbourg","67091",{"type":72,"coordinates":318},[319,320],7.74553,48.58392,{"lat":320,"lon":319},[323],{"name":324,"role":60,"phone":11,"phoneExt":11,"email":11},"Hamid MERDJI, MD",{"facility":326,"status":11,"city":327,"state":11,"zip":328,"country":69,"countryCode":70,"cosmosGeoPoint":329,"geoPoint":333,"contacts":334},"Service de Médecine Intensive-Réanimation, Hôpital Bretonneau, CHRU de Tours","Tours","37000",{"type":72,"coordinates":330},[331,332],0.70398,47.39484,{"lat":332,"lon":331},[335],{"name":336,"role":60,"phone":11,"phoneExt":11,"email":11},"Juliette POCQUET, MD",{"type":338,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100614003","remote-ischemic-postconditioning-in-septic-shock-100614003",false,"NCT07273942","Remote Ischemic Postconditioning in Septic Shock","RIPOST-sepsis","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Hospitalized in intensive care unit for less than 24 hours\n* Septic shock (Sepsis-3 definition) evolving for less than 18 hours\n* Preliminary written informed consent obtained from the patient or his\u002Fher close relative, or use of the emergency procedure in accordance with local regulations\n\nExclusion Criteria:\n\n* Contraindication of the use of a brachial pressure cuff on both arms\n* Cardiac arrest\n* Pregnancy or breast feeding\n* Participation in another interventional study\n* Lack of French national health insurance coverage\n* Patient with any legal protection measure","ALL","18 Years",{"count":349,"type":350},720,"ESTIMATED","INTERVENTIONAL",[353],"NA","Septic shock is a leading cause of death worldwide despite intensive research efforts. Only a few interventions have been proven to be effective in improving patient-centered outcomes. Recent clinical trials have reported the safety and efficacy of remote ischemic postconditioning (RIPOST) in a variety of pathologies, including myocardial infarction, cardiac surgery, and stroke. While RIPOST was mainly tested in pathologies with low mortality rates, several follow-up studies of large randomized clinical trials in acute myocardial infarction and in patients undergoing coronary artery bypass surgery have reported significant decreases (\\> 50%) in long-term mortality. Experimental studies and proof-of-concept clinical trials have also suggested the potential benefits of RIPOST on mortality in sepsis and septic shock. The present protocol aims to test whether this non-invasive, widely available, inexpensive, and innovative intervention can improve survival in septic shock.",[356],"Adult Patients With Septic Shock Admitted in Intensive Care Unit",[358,359,360,361,362],"Septic shock","Remote conditioning","Ischemic conditioning","Ischemia-reperfusion","Intensive care unit","NOT_YET_RECRUITING","2026-10-08",{"date":366,"type":367},"2026-10-09","ACTUAL",{"date":369,"type":350},"2027-01",{"date":371,"type":350},"2029-04",{"name":5,"class":6},23]