[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646327":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":38,"responsibleParty":52,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":25,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Oxford","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Biofeedback","EXPERIMENTAL","The participants in the active group will receive repeated active biofeedback training sessions.",[13],"Behavioral: Active Biofeedback",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Biofeedback","SHAM_COMPARATOR","The participants in the sham group will receive repeated sham biofeedback training sessions.",[19],"Behavioral: Sham Biofeedback",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","The active biofeedback session will be done within the 7T MRI. It will include MOTIVATE and active rest trials. During each MOTIVATE trial, subjects will be instructed to generate a heightened state of motivation. Subjects will simultaneously view a progress bar on the screen during MOTIVATE trials that represents their VTA activity and they will be trained to try to increase the level of the bar by motivating themselves.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"The sham biofeedback session resembles the active condition, however, the progress bar seen during the MOTIVATE trials will represent yoked sham values.",[15],[30],{"name":31,"affiliation":5,"role":32},"Laurel S Morris, Dr","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","01865 (6)16577","laurel.morris@ndcn.ox.ac.uk",[39],{"facility":40,"status":41,"city":42,"state":25,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":25},"Oxford Centre for Integrative Neuroimaging (OxCIN) FMRIB, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital","RECRUITING","Oxford","OX39DU","United Kingdom","UK",{"type":47,"coordinates":48},"Point",[49,50],-1.25596,51.75222,{"lat":50,"lon":49},{"type":53,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[55],{"name":56,"class":6},"Wellcome Trust","100646327","repeated-real-time-biofeedback-with-7-tesla-mri-for-treatment-of-depression-100646327",false,"NCT07694076","Repeated Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression","Inclusion Criteria:\n\n* Male or female aged 18-65 years;\n* Meets DSM-5 criteria for major depressive disorder (MDD) as determined by the Structured Clinical Interview for DSM-5 Axis Disorders (SCID) or the Mini International Neuropsychiatric Interview (MINI); with a current major depressive episode.\n* Participants must have a level of understanding of the English language sufficient to agree to all tests and examinations required by the study and must be able to participate fully in the informed consent process.\n\nExclusion Criteria:\n\n* Current or history of schizophrenia or other psychotic disorder, neurodevelopmental disorder, neurocognitive disorder or cognitive impairment\n* Active substance use disorder within the past 1 year;\n* Any unstable medical illnesses;\n* Women who are pregnant;\n* Any contraindications to MRI\n* Antidepressant medication initiated within 2 weeks of the Baseline Assessment and concomitant use of any other medication with central nervous system activity during active participation;\n* Active suicidal intent or plan.","ALL","18 Years","65 Years",{"count":67,"type":68},60,"ESTIMATED","INTERVENTIONAL",[71],"NA","Previous work demonstrated that individuals are able to self-regulate their ventral tegmental area (VTA) activity using real-time biofeedback. The current study expands this approach to a larger sample with repeated training sessions to more robustly characterize the effects of VTA modulation. The study will assess change in mood and motivation-related measures, as well as neural activity and connectivity changes.",[74],"Major Depressive Disorder (MDD)",[76,77,78,79,80],"Brain imaging","Biofeedback","7-Tesla MRI","Depression","Dopamine","2026-07-06",{"date":83,"type":84},"2026-07-09","ACTUAL",{"date":86,"type":68},"2026-06",{"date":88,"type":68},"2033-06",{"name":5,"class":6},1]