[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650327":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":30,"responsibleParty":70,"collaborators":10,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":10,"eligibilityCriteria":77,"healthyVolunteers":74,"sex":78,"minAge":79,"maxAge":10,"enrollmentInfo":80,"targetDuration":83,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"University of Florida","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Adult Lung Transplant Candidates",null,"adults enrolled for in-hospital evaluation for lung transplant and listed for surgery who undergo serial assessments of respiratory and limb muscle properties before transplantation and during the early postoperative period. Assessments include ultrasound imaging, respiratory and limb strength testing, physical performance measures, patient-reported outcomes, and collection of clinical outcomes from the medical record.",[13],"Diagnostic Test: Respiratory and Limb Muscle Assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Respiratory and Limb Muscle Assessment","Participants undergo serial assessments of respiratory and limb muscle structure and function before and after lung transplantation. Assessments include ultrasound imaging of the diaphragm, rectus abdominis, and quadriceps muscles; respiratory muscle strength testing; handgrip strength testing; knee extension strength testing; physical performance measures; and patient-reported outcome questionnaires.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Barbara K Smith, PhD, PT","CONTACT","352-294-5315","bksmith@ufl.edu",{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},"Wagner Souza Leite, PT","(352) 273-6085","wagnersouzaleite@ufl.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"UF Health Shands Medical Center","RECRUITING","Gainesville","Florida","32608","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-82.32483,29.65163,{"lat":43,"lon":42},[46,50,53,56,58,60,62,64,66,68],{"name":47,"role":23,"phone":48,"phoneExt":10,"email":49},"Mindaugas Rackauskas, MD, PhD","(352) 265-5470","mindaugas.Rackauskas@surgery.ufl.edu",{"name":51,"role":23,"phone":48,"phoneExt":10,"email":52},"Mohammad A. Aladaileh, MBBS, MRCSI, EBCTS, FRCSIC-Th","maladaileh@ufl.edu",{"name":54,"role":55,"phone":10,"phoneExt":10,"email":10},"Barbara K Smith, PhD","PRINCIPAL_INVESTIGATOR",{"name":27,"role":57,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":59,"role":57,"phone":10,"phoneExt":10,"email":10},"Sandra Morgan, RN, PhD",{"name":61,"role":57,"phone":10,"phoneExt":10,"email":10},"Jessica Cornman, PT",{"name":63,"role":57,"phone":10,"phoneExt":10,"email":10},"May Smith-Hublou, PhD, CCC-SLP",{"name":65,"role":57,"phone":10,"phoneExt":10,"email":10},"Ushna Khan, MD",{"name":67,"role":57,"phone":10,"phoneExt":10,"email":10},"Amir M Emtiazjoo, MD, MSc",{"name":69,"role":57,"phone":10,"phoneExt":10,"email":10},"Marc O Maybauer, MD, PhD, EDIC, FCCP, FACC, FAS",{"type":71,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100650327","respiratory-limb-muscle-properties-and-physical-performance-in-adult-lung-transplant-recipients-100650327",false,"NCT07747337","Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients","Inclusion Criteria:\n\n* 18 years or older.\n* Hospitalized as potential candidates for single- or bilateral-lung transplant surgery.\n* Hemodynamically stable for out-of-bed mobilization\n\nExclusion Criteria:\n\n* Baseline cognitive impairment\n* History of previous solid organ transplantation or thoracic surgery\n* Existing phrenic nerve lesion\n* Lower limb amputation or fracture\n* External fixators or open wounds of the lower extremities\n* Diagnosed neuromuscular disorder.\n* Morbid obesity (body mass index \\>45 kg\u002Fm²).\n* Any other medical condition that, in the opinion of the investigators, would make participation unsuitable.","ALL","18 Years",{"count":81,"type":82},36,"ESTIMATED","3 Months","OBSERVATIONAL","The goal of this observational study is to evaluate respiratory and limb muscle properties in adults awaiting lung transplantation and determine how these measures relate to physical performance, symptoms, and recovery after transplantation. Respiratory and limb muscle weakness may contribute to impaired mobility, frailty, and delayed postoperative recovery, but their specific role in lung transplant candidates is not well understood. Participants will undergo muscle ultrasound imaging at weekly basis, respiratory and limb strength testing, physical performance assessments, and symptom questionnaires once before and after transplantation. Researchers will also collect information from medical records regarding intensive care unit stay, hospital length of stay, rehabilitation participation, and postoperative recovery outcomes.",[87,88],"Lung Transplantation","End Stage Lung Disease",[90,91,92,93,94,95],"lung transplant candidates","diaphragm ultrasound","limb muscles ultrasound","respiratory muscles","quadriceps muscles","rehabilitation","2026-07-30",{"date":98,"type":99},"2026-08-05","ACTUAL",{"date":101,"type":99},"2026-02-05",{"date":103,"type":82},"2027-07",{"name":5,"class":6},1]