[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652260":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":64,"collaborators":25,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":25,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":90,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Auckland, New Zealand","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Stimulation-Enhanced Physical Therapy","EXPERIMENTAL","Participants complete baseline assessments up to 7 days prior to the first treatment day. On the first treatment day participants meet with their treating team to review their current symptoms and discuss FND to ensure they understand the condition. On the second treatment day the treating team delivers the experimental intervention. The primary outcome measure is obtained at the end of this session by the blinded clinical assessor. On the third treatment day the treating team discusses ongoing self-management with the participant.",[13],"Combination Product: Stimulation-Enhanced Physical Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Physical Therapy","ACTIVE_COMPARATOR","Participants complete baseline assessments up to 7 days prior to the first treatment day. On the first treatment day participants meet with their treating team to review their current symptoms and discuss FND to ensure they understand the condition. On the second treatment day the treating team delivers the active comparator intervention. The primary outcome measure is obtained at the end of this session by the blinded clinical assessor. On the third treatment day the treating team discusses ongoing self-management with the participant.",[19],"Other: Active Comparator",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"COMBINATION_PRODUCT","The intervention uses Transcranial Magnetic Stimulation (TMS) to activate the motor pathways from the primary motor cortex to affected lower limb muscles. This is followed by specialist physical therapy applying consensus recommendations for the treatment of movement symptoms due to FND. Key elements include distraction, momentum, and exploratory movement.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Active Comparator","The active comparator uses structured goal-setting and movement imagery to prepare for physical therapy. This is followed by specialist physical therapy applying consensus recommendations for the treatment of movement symptoms due to FND. Key elements include distraction, momentum, and progressive movement retraining.",[15],[31],{"name":32,"affiliation":5,"role":33},"Cathy Stinear","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","+64210770788","c.stinear@auckland.ac.nz",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Winston Byblow","+640211444252","w.byblow@auckland.ac.nz",[44],{"facility":45,"status":25,"city":46,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Clinical Research Centre, Grafton Campus, University of Auckland","Auckland","1142","New Zealand","NZ",{"type":51,"coordinates":52},"Point",[53,54],174.76349,-36.84853,{"lat":54,"lon":53},[57,59,62],{"name":32,"role":36,"phone":58,"phoneExt":25,"email":38},"+64 21 077 0788",{"name":60,"role":36,"phone":25,"phoneExt":25,"email":61},"Ben Scrivener","b.scrivener@auckland.ac.nz",{"name":63,"role":33,"phone":25,"phoneExt":25,"email":25},"Cathy Stinear, PhD",{"type":33,"investigatorFullName":32,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Professor","100652260","restoring-independence-with-stimulation-enhanced-treatment-for-people-with-functional-neurological-disorder-100652260",false,"NCT07769970","Restoring Independence With Stimulation-Enhanced Treatment for People With Functional Neurological Disorder","A Phase 3, Single-site, Assessor-blinded, Randomised Controlled Trial of Transcranial Magnetic Stimulation-Enhanced Treatment to Restore Movement Agency and Walking Independence in People With Functional Neurological Disorder","RISE-FND","Inclusion Criteria:\n\n* Clinically established diagnosis of FND or an equivalent term\n* Investigations are accepted as complete by the patient and treating physician\n* Walking difficulty that prevents crossing the road unaided at a traffic light pedestrian crossing\n* Lower limb functional weakness\n* 30 days or more since first onset of functional motor symptoms\n* Tinetti POMA score \\\u003C 21\u002F28\n\nExclusion Criteria:\n\n* Age \\\u003C 21 years\n* Living with a parent or guardian who provides primary emotional support and assistance with most daily tasks\n* Medical instability precluding safe participation in physical therapy\n* Cognitive or communication impairment precluding informed consent or the ability to effectively engage in education aspects of the trial with family support\n* Untreated and severe psychiatric illness affecting the ability to safely participate\n* Co-existing non-FND neurological or musculoskeletal impairments restricting walking independence\n* A primary diagnosis of chronic pain or chronic fatigue syndrome\n* Pain significantly limiting standing or walking\n* Prior treatment for FND that included Transcranial Magnetic Stimulation (TMS)\n* Contraindicated to TMS as determined using a standard safety screening checklist","ALL","21 Years",{"count":77,"type":78},60,"ESTIMATED","INTERVENTIONAL",[81],"NA","The goal of this clinical trial is to test a new treatment for adults with walking problems due to Functional Neurological Disorder (FND).\n\nThe main question the trial aims to answer is:\n\n\\- Is stimulation-enhanced physical therapy an effective treatment for walking problems due to FND?\n\nResearchers will compare the stimulation-enhanced physical therapy to gold-standard physical therapy.\n\nParticipants will:\n\n* Complete three in-person sessions on three consecutive days\n* Complete follow-up assessments by video call at 7 days, 30 days and 90 days after treatment",[84,85],"Functional Neurological Disorder","Conversion Disorder",[84,85,87,88,89],"Walking","Weakness","Paralysis","NOT_YET_RECRUITING","2026-08-12",{"date":93,"type":94},"2026-08-18","ACTUAL",{"date":96,"type":78},"2026-11",{"date":98,"type":78},"2030-04",{"name":5,"class":6},1]