[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658867":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":26,"studyPopulation":27,"armGroups":28,"interventions":23,"overallOfficials":23,"centralContacts":37,"locations":46,"responsibleParty":63,"collaborators":23,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":23,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":81,"studyType":82,"phases":23,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":90,"whyStopped":23,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Adiyaman University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Correlation Between Periodontal Disease Severity and Choroidal Thickness","The correlation between periodontal disease severity and choroidal thickness will be assessed using Spearman's correlation coefficient (rₛ). Periodontal disease severity will be assessed using probing pocket depth (PPD) and clinical attachment level (CAL), measured in millimeters (mm) using a periodontal probe. Choroidal thickness will be measured in micrometers (µm) using spectral-domain optical coherence tomography (SD-OCT).","Baseline",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Correlation Between Periodontal Disease Severity and Retinal Nerve Fiber Layer (RNFL) Thickness","The correlation between periodontal disease severity and retinal nerve fiber layer (RNFL) thickness will be evaluated. Periodontal disease severity will be assessed using clinical periodontal parameters, including probing pocket depth (PPD) and clinical attachment level (CAL), measured in millimeters (mm). RNFL thickness will be measured in micrometers (µm) using spectral-domain optical coherence tomography (SD-OCT). The correlation will be quantified using Spearman's correlation coefficient (rₛ).",{"measure":18,"description":19,"timeFrame":12},"Correlation Between Periodontal Disease Severity and Ganglion Cell Layer (GCL) Thickness","The correlation between periodontal disease severity and ganglion cell layer (GCL) thickness will be evaluated. Periodontal disease severity will be assessed using clinical periodontal parameters, including probing pocket depth (PPD) and clinical attachment level (CAL), measured in millimeters (mm). GCL thickness will be measured in micrometers (µm) using spectral-domain optical coherence tomography (SD-OCT). The correlation will be quantified using Spearman's correlation coefficient (rₛ).",{"measure":21,"description":22,"timeFrame":12},"Correlation Between Periodontal Disease Severity and Inner Plexiform Layer (IPL) Thickness","The correlation between periodontal disease severity and inner plexiform layer (IPL) thickness will be evaluated. Periodontal disease severity will be assessed using clinical periodontal parameters, including probing pocket depth (PPD) and clinical attachment level (CAL), measured in millimeters (mm). IPL thickness will be measured in micrometers (µm) using spectral-domain optical coherence tomography (SD-OCT). The correlation will be quantified using Spearman's correlation coefficient (rₛ).",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":6,"timePerspective":25,"maskingInfo":23},"CROSS_SECTIONAL","Periodontal disease, by causing chronic inflammation, can affect not only oral tissues but also systemic organs. While the potential link between periodontal disease and eye diseases has attracted attention in recent years, data regarding retinal and choroidal structural changes are limited. In this study, periodontal clinical findings were compared with measurements of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroid thickness obtained using spectral-domain optical coherence tomography (SD-OCT) in a total of 80 individuals diagnosed with periodontal health, gingivitis, early periodontitis, and advanced periodontitis. The findings showed that choroidal thickness increased and GCL thickness decreased as the severity of periodontal disease increased. This study aims to contribute to a better understanding of the relationship between periodontal disease and ocular structural changes and to provide a basis for future prospective research.\n\nGroup 1: Periodontal Healthy\n\nParticipants with clinically healthy periodontal tissues and no evidence of gingivitis or periodontitis.\n\nGroup 2: Gingivitis\n\nParticipants diagnosed with gingivitis, presenting gingival inflammation without clinical attachment loss.\n\nGroup 3: Early Periodontitis\n\nParticipants diagnosed with early-stage periodontitis based on clinical periodontal examination.\n\nGroup 4: Advanced Periodontitis\n\nParticipants diagnosed with advanced periodontitis with greater periodontal tissue destruction.","The study population consisted of 80 systemically healthy, non-smoking adults who underwent comprehensive periodontal examination and spectral-domain optical coherence tomography (SD-OCT). Participants were classified into four groups according to their periodontal status (periodontally healthy, gingivitis, early periodontitis, and advanced periodontitis). All participants provided written informed consent before enrollment.",[29,31,33,35],{"label":30,"type":23,"description":23,"interventionNames":23},"Periodontal Healthy",{"label":32,"type":23,"description":23,"interventionNames":23},"Gingivitis",{"label":34,"type":23,"description":23,"interventionNames":23},"Early Periodontitis",{"label":36,"type":23,"description":23,"interventionNames":23},"Advanced Periodontitis",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":23,"email":42},"Zeliha B ÇAKIR ERDİL, DDS","CONTACT","+905059444038","bskcakirr@gmail.com",{"name":44,"role":40,"phone":23,"phoneExt":23,"email":45},"Metin Çalışır, Prof.DR","metincalisir@adiyaman.edu.tr",[47],{"facility":48,"status":23,"city":49,"state":50,"zip":51,"country":52,"countryCode":23,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Faculty of Dentistry, Adıyaman University","Adıyaman","Adıyaman Province","02030","Turkey (Türkiye)",{"type":54,"coordinates":55},"Point",[56,57],38.27629,37.76441,{"lat":57,"lon":56},[60],{"name":61,"role":40,"phone":62,"phoneExt":23,"email":42},"Zeliha B ERDİL, DDS","05059444038",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"SPONSOR_INVESTIGATOR","Zeliha Başak Çakır Erdil","Research Assistant in Periodontology","100658867","retinal-and-choroidal-changes-in-periodontal-disease-100658867",false,"NCT07856901","Retinal and Choroidal Changes in Periodontal Disease","RETİNAL AND CHOROİDAL STRUCTURAL ALTERATİONS ACROSS THE PERİODONTAL DİSEASE CONTİNUUM: A CROSS-SECTİONAL OBSERVATİONAL STUDY","Inclusion Criteria:\n\nSystemically healthy adults. Non-smokers (no current or previous tobacco use). Participants who underwent optical coherence tomography (OCT) imaging. Participants who provided written informed consent and agreed to participate in the study.\n\nExclusion Criteria:\n\nPresence of any systemic disease. Current or former smokers. Participants with incomplete clinical or OCT data. Individuals who did not provide written informed consent.\n\n\\-",true,"ALL","20 Years","54 Years",{"count":79,"type":80},80,"ESTIMATED","1 Day","OBSERVATIONAL","Advanced PeriodontitisIn this cross-sectional study, the relationship between periodontal disease severity and retinal and choroidal structural changes was evaluated using SD-OCT. Data from a total of 80 participants were examined. It was found that choroidal thickness increased and ganglion cell layer thickness decreased as periodontal disease severity increased, while no significant relationship was found in RNFL and IPL thicknesses. The findings support a possible association between periodontal disease and ocular structural changes.",[85,86,87],"Periodontal Diseases","Periodontal Diseases Inflammation","Retinal Thickening",[89],"Retinal degeneration ; Tomography, Optical Coherence ; Periodontitis ; gingivitis; Retinal Ganglion Cells ; Periodontal Index","NOT_YET_RECRUITING","2026-09-28",{"date":93,"type":94},"2026-10-05","ACTUAL",{"date":96,"type":80},"2026-10",{"date":96,"type":80},{"name":65,"class":6},1]