[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658248":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":33,"studyPopulation":34,"armGroups":35,"interventions":29,"overallOfficials":39,"centralContacts":44,"locations":29,"responsibleParty":50,"collaborators":29,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":29,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":29,"studyType":67,"phases":29,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":76,"whyStopped":29,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":29},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Proportion of children with unfavorable outcome","Proportion of children who develop one or more of the following during hospital stay: acute liver failure, hepatic encephalopathy, acute kidney injury, ICU admission, prolonged hospital stay (\\>7 days), or death.","Baseline",[14,17,20,23,26],{"measure":15,"description":16,"timeFrame":12},"Proportion of children with acute liver failure","Proportion of children who develop acute liver failure during hospital stay.",{"measure":18,"description":19,"timeFrame":12},"Proportion of children with hepatic encephalopathy","Proportion of children who develop hepatic encephalopathy (any West Haven grade) during hospital stay.",{"measure":21,"description":22,"timeFrame":12},"Mean duration of hospital stay","Mean number of days of hospitalization.",{"measure":24,"description":25,"timeFrame":12},"Proportion of children requiring ICU admission","Proportion of children who require intensive care unit admission.",{"measure":27,"description":28,"timeFrame":12},"Mortality rate","Proportion of children who die during hospital stay.",null,{"allocation":29,"interventionModel":29,"interventionModelDescription":29,"primaryPurpose":29,"observationalModel":31,"timePerspective":32,"maskingInfo":29},"COHORT","PROSPECTIVE","Hepatitis A virus infection is a common cause of acute hepatitis in children in Egypt. While most cases recover completely, some children may develop complications such as prolonged cholestasis, acute liver failure, or hepatic encephalopathy.\n\nThis observational study will include children aged 1 month to 18 years with confirmed acute hepatitis A infection (positive Anti-HAV IgM). Patients will be followed during their hospital stay to assess clinical course and outcomes.","Children with confirmed acute hepatitis A infection admitted to or presenting at Assiut University Children Hospital.",[36],{"label":37,"type":29,"description":38,"interventionNames":29},"Single cohort: Children with acute hepatitis A","Children aged 1 month to 18 years with confirmed acute hepatitis A infection who will be followed during hospital stay to assess clinical course and outcomes.",[40],{"name":41,"affiliation":42,"role":43},"Ahlam B Ali, prof","Pediatrics Department, Assiut University Hospitals","STUDY_CHAIR",[45],{"name":46,"role":47,"phone":48,"phoneExt":29,"email":49},"Nada A Fouad, Resident","CONTACT","+20 11 18762071","Nada.17289945@med.aun.edu.eg",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Nada Ashraf Fouad","Resident Physician, Department of Pediatrics","100658248","risk-factors-and-outcomes-of-hepatitis-a-in-children-100658248",false,"NCT07848321","Risk Factors and Outcomes of Hepatitis A in Children","Risk Factors, Clinical Course and Predictors of Outcome in Children With Hepatitis A Infection Admitted in Assiut University Children Hospital","Inclusion Criteria:\n\n* Age 1 month to 18 years\n* Confirmed acute hepatitis A infection by positive Anti-HAV IgM\n* Written informed consent from parents or legal guardians\n\nExclusion Criteria:\n\n* \\- Co-infection with hepatitis B, hepatitis C, or hepatitis E\n* Chronic liver diseases (autoimmune hepatitis, Wilson disease, metabolic liver diseases)","ALL","1 Month","18 Years",{"count":65,"type":66},190,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the risk factors, clinical course, and outcomes among children with acute hepatitis A infection admitted to Assiut University Children Hospital.",[70,71],"Hepatitis A","Acute Hepatitis",[70,73,74,75],"Assiut","Children","Acute liver failure","NOT_YET_RECRUITING","2026-09-28",{"date":79,"type":80},"2026-09-30","ACTUAL",{"date":82,"type":66},"2026-09-26",{"date":84,"type":66},"2028-03-25",{"name":5,"class":6}]