[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655898":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":33,"studyPopulation":34,"armGroups":35,"interventions":29,"overallOfficials":42,"centralContacts":47,"locations":29,"responsibleParty":53,"collaborators":29,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":29,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":71,"studyType":72,"phases":29,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":85,"whyStopped":29,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":29},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Prevalence of risk factors in ASD versus controls","Proportion of children with specific antenatal, perinatal, and postnatal risk factors (advanced parental age, consanguinity, maternal infection, gestational diabetes, birth asphyxia, NICU admission, and family history of ASD) among ASD cases compared with age- and sex-matched controls.","Baseline",[14,18,21,25],{"measure":15,"description":16,"timeFrame":17},"Change in Childhood Autism Rating Scale score","Change in Childhood Autism Rating Scale (CARS) total score from baseline to 6 months in children with ASD. CARS ranges from 15 to 60; higher scores indicate greater autism severity.","From baseline to 6 months",{"measure":19,"description":20,"timeFrame":17},"Change in Vineland Adaptive Behavior Scales score","Change in Vineland Adaptive Behavior Scales composite score from baseline to 6 months in children with ASD. Higher scores indicate better adaptive functioning.",{"measure":22,"description":23,"timeFrame":24},"Response to early intervention","Proportion of children with ASD showing clinical improvement after speech, occupational, and behavioral therapy.","At 6 months",{"measure":26,"description":27,"timeFrame":28},"Development of comorbidities","Proportion of children with ASD who develop associated comorbidities (seizures, gastrointestinal problems, sleep disturbances) during follow-up.","Through 6 months",null,{"allocation":29,"interventionModel":29,"interventionModelDescription":29,"primaryPurpose":29,"observationalModel":31,"timePerspective":32,"maskingInfo":29},"CASE_CONTROL","PROSPECTIVE","Autism spectrum disorder is a neurodevelopmental condition with multifactorial etiology involving genetic and environmental factors. This observational case-control study will include children aged 3 to 17 years diagnosed with ASD according to DSM-5 criteria and age- and sex-matched controls without neurodevelopmental disorders.\n\nRisk factors (antenatal, perinatal, and postnatal) will be compared between cases and controls. Children with ASD will be followed for 6 months to assess changes in symptom severity and adaptive functioning.","Children aged 3 to 17 years attending Assiut University Children's Hospital (Pediatric Neurology Unit).",[36,39],{"label":37,"type":29,"description":38,"interventionNames":29},"ASD Cases","Children aged 3 to 17 years with confirmed diagnosis of autism spectrum disorder according to DSM-5 criteria, supported by standardized assessment tools (e.g., CARS), attending the Pediatric Neurology Unit of Assiut University Children's Hospital.",{"label":40,"type":29,"description":41,"interventionNames":29},"Controls","Age- and sex-matched children without autism spectrum disorder or other neurodevelopmental disorders, attending the same hospital during the same study period.",[43],{"name":44,"affiliation":45,"role":46},"Abdellatif M Abdelmoez, prof","pediatics Department, Assiut University Hospitals","STUDY_CHAIR",[48],{"name":49,"role":50,"phone":51,"phoneExt":29,"email":52},"Yasmin A Mohamed, Resident","CONTACT","+20 11 13449521","Jasmine.18313474@med.aun.edu.eg",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Yasmin Abdelrahman Fathallah Mohamed","Resident Physician","100655898","risk-factors-and-prognosis-of-autism-spectrum-disorder-100655898",false,"NCT07818460","Risk Factors and Prognosis of Autism Spectrum Disorder","Risk Factors and Prognosis of Autism Spectrum Disorder in Children Attending Assiut University Children's Hospital","Inclusion Criteria\n\nInclusion Criteria (Cases):\n\n* Age 3 to 17 years\n* Confirmed diagnosis of ASD according to DSM-5 criteria, supported by standardized tools (e.g., CARS)\n* Parent or legal guardian able and willing to provide informed consent\n\nInclusion Criteria (Controls):\n\n\\- Age- and sex-matched children without ASD or other neurodevelopmental disorders\n\nExclusion Criteria:\n\n* Age below 3 years or above 17 years\n* Known chromosomal or genetic syndrome associated with secondary autistic features (e.g., Fragile X, Down syndrome), unless studied as a separate subgroup\n* Incomplete medical records\n* Refusal of parents\u002Fguardians to participate\n* Loss to follow-up before the minimum 6-month prognostic assessment",true,"ALL","3 Years","17 Years",{"count":69,"type":70},84,"ESTIMATED","6 Months","OBSERVATIONAL","This case-control study with prospective follow-up aims to identify risk factors associated with autism spectrum disorder and to evaluate the prognosis of children with ASD attending Assiut University Children's Hospital.",[75,76,77],"Autism Spectrum Disorder","Autistic Disorder","Child Development Disorders, Pervasive",[79,80,81,82,83,84],"Autism spectrum disorder","Risk factors","Prognosis","CARS","Children","Assiut","NOT_YET_RECRUITING","2026-09-11",{"date":88,"type":89},"2026-09-15","ACTUAL",{"date":91,"type":70},"2026-09-10",{"date":93,"type":70},"2028-04-10",{"name":5,"class":6}]