[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649379":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":35,"centralContacts":39,"locations":45,"responsibleParty":62,"collaborators":64,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":10,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Bordeaux","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Alcohol",null,"Participants with various level of Alcohol Use Disorder severity",[13],"Other: Observational assessments (EMA and annual DSM-5 evaluations)",{"label":15,"type":10,"description":16,"interventionNames":17},"Tobacco","Participants with various level of Tobacco Use Disorder severity",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Cannabis","Participants with various level of CannabisUse Disorder severity",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Opiates","Participants with various level of Opiates Use Disorder severity.",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Stimulants","Participants with various level of Stimulant Use Disorder severity",[13],[31],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Observational assessments (EMA and annual DSM-5 evaluations)","Participants are observed over two years. Annual DSM-5 diagnostic criteria for substance use disorders (SUD) are assessed, and participants complete 2-week EMA protocols measuring substance use, craving, and related factors four times per day. No intervention is administered.",[9,19,23,27,15],[36],{"name":37,"affiliation":5,"role":38},"Fuschia SERRE","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":10,"email":44},"Fuschia SERRE, Ph-D","CONTACT","+33 05 56 56 17 38","fuschia.serre@u-bordeaux.fr",[46],{"facility":47,"status":48,"city":49,"state":10,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Université de Bordeaux CNRS UMR 6033 SANPSY","RECRUITING","Bordeaux","33000","France","FR",{"type":54,"coordinates":55},"Point",[56,57],-0.58046,44.84124,{"lat":57,"lon":56},[60],{"name":61,"role":42,"phone":10,"phoneExt":10,"email":44},"Fuschia SERRE, Ph.D",{"type":63,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[65],{"name":66,"class":6},"Hospices Civils de Lyon","100649379","role-of-craving-in-the-transition-across-level-of-addiction-severity-a-longitudinal-study-100649379",false,"NCT07734363","Role of Craving in the Transition Across Level of Addiction Severity: A Longitudinal Study.","Symptom Networks Characteristics and Centrality of Craving as Markers of Transition Across Levels of Addiction Severity: A Longitudinal Study","CARDEMA","Inclusion Criteria\n\n* Be over 18 years of age\n* Identify a primary substance as a main problematic substance use.\n* Be a regular user (at least twice a week in the last 30 days) of a primary substance (defined as their main problematic substance use).\n* Present a current diagnosis of SUD for this primary substance according to DSM-5 criteria.\n\nExclusion Criteria\n\n* Medical, psychiatric or addiction condition that warrants immediate inpatient treatment intervention.\n* Somatic, cognitive or other disorders preventing the use of the smartphone device (deafness, impaired vision, illiteracy….).\n* Not being familiar with the use of smartphone\n* Having a smartphone not compatible with the application and being unable to visit the laboratory to receive a loaner phone for the study.\n* Difficulty in understanding and\u002For writing and\u002For reading French.\n* Individuals participating in another study that includes an ongoing exclusion period.\n* Be deprived of liberty due to an ongoing legal procedure.\n* Be under legal protection.\n* Be under guardianship or conservatorship.","ALL","18 Years",{"count":78,"type":79},700,"ESTIMATED","OBSERVATIONAL","Substance\u002FAlcohol Use disorders are defined as a loss of control over the use despite harmul consequences, as well as an intense and persistent urge to use, also called craving. Previous research has shown that craving is central among the diagnostic criteria for addiction, suggesting that it may be important in the onset and persistence of addiction.\n\nAddiction develops progressively, and it appears crucial to identify predictive markers of the transition from one level of severity to another over time. One hypothesis is that more closely linked symptoms (meaning symptoms that influence each other more) could be associated with greater severity and\u002For with the evolution of addiction severity over time.\n\nThe aim of this project is to explore how the characteristics of the association between addiction symptoms (diagnostic criteria and symptoms as they occur in daily life), and the importance of craving relative to other symptoms, could serve as markers of different addiction severities and of the transition across these levels of severity.",[83],"Addiction",[85,83,86,87,88,89],"Substance Use Disorder","Symptoms network","Ecological Momentary Assessment","Trajectory","Staging","2026-07-23",{"date":92,"type":93},"2026-07-29","ACTUAL",{"date":95,"type":93},"2026-05-20",{"date":97,"type":79},"2031-06",{"name":5,"class":6},1]