[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658456":3},{"organization":4,"outcomesModule":7,"designInfo":19,"detailedDescription":22,"studyPopulation":23,"armGroups":18,"interventions":24,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":55,"collaborators":18,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":18,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":18,"studyType":72,"phases":18,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":81,"whyStopped":18,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"Improvement or Relief of Local Compressive Symptoms","Assessment of changes in patient-reported compressive symptoms (such as dysphagia, dyspnea, and local neck discomfort or pressure) following total thyroidectomy compared to baseline status.","6 months postoperatively",[14],{"measure":15,"description":16,"timeFrame":17},"Incidence of Postoperative Complications","Rate of surgical complications including transient or permanent hypocalcemia, recurrent laryngeal nerve injury, and wound complications.","Up to 30 days postoperatively",null,{"allocation":18,"interventionModel":18,"interventionModelDescription":18,"primaryPurpose":18,"observationalModel":20,"timePerspective":21,"maskingInfo":18},"COHORT","PROSPECTIVE","Hashimoto's thyroiditis is a chronic autoimmune disease often presenting with goiter and local pressure symptoms. While levothyroxine replacement is standard for hypothyroidism, persistent compressive symptoms, cosmetic concerns, or suspicion of malignancy may necessitate surgical intervention.\n\nThis study investigates patients diagnosed with Hashimoto's thyroiditis presenting with significant local symptoms. Eligible patients undergoing total thyroidectomy will be evaluated preoperatively and postoperatively to assess symptom resolution, postoperative complication rates (such as hypocalcemia and recurrent laryngeal nerve injury), and overall patient satisfaction following surgery.","Patients diagnosed with Hashimoto's thyroiditis who suffer from persistent local compressive symptoms and undergo total thyroidectomy at the Department of Surgery, Assiut University Hospitals.",[25],{"type":26,"name":27,"description":28,"armGroupLabels":18,"otherNames":18},"PROCEDURE","Total Thyroidectomy","Surgical removal of the entire thyroid gland performed under general anesthesia for patients with Hashimoto's thyroiditis presenting with compressive or local neck symptoms.",[30],{"name":31,"affiliation":18,"role":32},"Ahmed Gamal Hamdan, Lecturer","STUDY_DIRECTOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":18,"email":38},"Ahmed Atef Muslim, Bachelor of Medicine and Surge","CONTACT","+201099626447","ahmed.atef.465.aa@gmail.com",[40],{"facility":41,"status":18,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Assiut University Hospitals","Asyut","Asyut Governorate","71515","Egypt","EG",{"type":48,"coordinates":49},"Point",[50,51],31.18368,27.18096,{"lat":51,"lon":50},[54],{"name":35,"role":36,"phone":37,"phoneExt":18,"email":38},{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Ahmed Atef Muslim Hassan","Resident doctor","100658456","role-of-total-thyroidectomy-in-relieving-local-symptoms-in-hashimotos-thyroiditis-100658456",false,"NCT07852026","Role of Total Thyroidectomy in Relieving Local Symptoms in Hashimoto's Thyroiditis","The Role of Total Thyroidectomy in Relieving Chronic Local Symptoms Associated With Hashimoto's Thyroiditis: Prospective Cohort Study","Inclusion Criteria:\n\n* Adults patients with confirmed Hashimoto's thyroiditis (elevated serum anti-thyroid peroxidase \\\\anti-thyroglobulin antibodies, characteristic ultrasound findings and\u002For positive fine needle aspiration cytology)\n* Biochemically euthyroid with normal thyroid function test.\n* Presence of persistent local symptoms (neck pain, throat discomfort,neck tightness,chocking) for more than 6 months\n* Patient fit and motivated to surgery.\n\nExclusion Criteria:\n\n* Confirmed or high-suspicion thyroid malignancy (Bethesda V or IV on FNAC\n* Previous thyroid or neck surgery\n* Patient refusal to participate in the study\n* Severe comorbidities precluding general anesthesia\n* Active psychiatric illness","ALL","18 Years","70 Years",{"count":70,"type":71},30,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the role and effectiveness of total thyroidectomy in relieving compressive and local symptoms (such as dysphagia, dyspnea, and anterior neck pain\u002Fdiscomfort) in patients with Hashimoto's thyroiditis who fail to improve with conservative medical management.",[75,76],"Hashimoto Thyroiditis","Goiter",[27,78,79,80],"Hashimoto's Thyroiditis","Compressive Symptoms","Thyroid Surgery","NOT_YET_RECRUITING","2026-09-25",{"date":84,"type":85},"2026-10-01","ACTUAL",{"date":84,"type":71},{"date":88,"type":71},"2028-06-01",{"name":5,"class":6},1]