[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617257":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":165,"collaborators":11,"id":167,"slug":168,"hasResults":169,"nctId":170,"briefTitle":171,"officialTitle":171,"acronym":11,"eligibilityCriteria":172,"healthyVolunteers":169,"sex":173,"minAge":174,"maxAge":11,"enrollmentInfo":175,"targetDuration":11,"studyType":178,"phases":179,"briefSummary":181,"conditions":182,"keywords":11,"overallStatus":69,"whyStopped":11,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":194},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual care Group","ACTIVE_COMPARATOR",null,[13],"Drug: Usual Care",{"label":15,"type":16,"description":11,"interventionNames":17},"Catheter Ablation Group","EXPERIMENTAL",[18],"Procedure: Catheter Ablation",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Catheter Ablation","For patients in the catheter ablation group, low-dose anticoagulation for 1 month after pulsed field ablation is recommended. Suggested regimens include rivaroxaban 10-15 mg once daily, dabigatran 110 mg twice daily, or edoxaban 30 mg once daily. For patients with paroxysmal atrial fibrillation (AF), an ablation strategy based on bilateral pulmonary vein isolation (PVI) is adopted. For patients with persistent AF, PVI plus ethanol infusion of the vein of Marshall and linear ablation (mitral isthmus, cavotricuspid isthmus, and left atrial roof) strategy is recommended. Other additional ablation strategies are determined by the operator.",[15],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"DRUG","Usual Care","Patients received standard medical therapy without anticoagulation.",[9],[31,35,37],{"name":32,"affiliation":33,"role":34},"Yan Wang","Xiamen Cardiovascular Hospital, Xiamen University","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Caihua Sang",{"name":38,"affiliation":5,"role":34},"Changsheng Ma",[40],{"name":41,"role":42,"phone":43,"phoneExt":11,"email":44},"Liu He","CONTACT","13810720787","theliu@139.com",[46,67,89,104,121,133,149],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"The First Affiliated Hospital of Anhui Medical University","NOT_YET_RECRUITING","Hefei","Anhui","230022","China","CN",{"type":55,"coordinates":56},"Point",[57,58],117.28083,31.86389,{"lat":58,"lon":57},[61,65],{"name":62,"role":42,"phone":63,"phoneExt":11,"email":64},"Ronghui Yu","+86 13901080383","ronghuiyu@vip.sina.com",{"name":66,"role":34,"phone":11,"phoneExt":11,"email":11},"Ronghui Yu, MD",{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":52,"countryCode":53,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Beijing Anzhen Hospital, Capital Medical University","RECRUITING","Beijing","Beijing Municipality","100029",{"type":55,"coordinates":74},[75,76],116.39723,39.9075,{"lat":76,"lon":75},[79,82,86,88],{"name":80,"role":42,"phone":81,"phoneExt":11,"email":44},"Liu HE, MD","+86 13810720787",{"name":83,"role":42,"phone":84,"phoneExt":11,"email":85},"Caihua Sang, MD","+86 010-81992281","sch9613070@sina.com",{"name":87,"role":34,"phone":11,"phoneExt":11,"email":11},"Changsheng Ma, MD",{"name":83,"role":34,"phone":11,"phoneExt":11,"email":11},{"facility":90,"status":69,"city":91,"state":92,"zip":11,"country":52,"countryCode":53,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Xiamen Cadiovascular Hospital","Xiamen","Fujian",{"type":55,"coordinates":94},[95,96],118.08187,24.47979,{"lat":96,"lon":95},[99,102],{"name":32,"role":42,"phone":100,"phoneExt":11,"email":101},"+86-0592-968120","wy@medmail.com.cn",{"name":103,"role":34,"phone":11,"phoneExt":11,"email":11},"Yan Wang, MD",{"facility":105,"status":48,"city":106,"state":107,"zip":108,"country":52,"countryCode":53,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"The First Affiliated Hospital of Harbin Medical University","Harbin","Heilongjiang","150001",{"type":55,"coordinates":110},[111,112],126.65,45.75,{"lat":112,"lon":111},[115,119],{"name":116,"role":42,"phone":117,"phoneExt":11,"email":118},"Yue Li","+86 13945057313","ly99ly@vip.163.com",{"name":120,"role":34,"phone":11,"phoneExt":11,"email":11},"Yue Li, MD",{"facility":122,"status":48,"city":106,"state":107,"zip":11,"country":52,"countryCode":53,"cosmosGeoPoint":123,"geoPoint":125,"contacts":126},"The Second Affiliated Hospital of Harbin Medical University",{"type":55,"coordinates":124},[111,112],{"lat":112,"lon":111},[127,131],{"name":128,"role":42,"phone":129,"phoneExt":11,"email":130},"Bo Yu","+86-0451-86605084","yubodr@163.coms",{"name":132,"role":34,"phone":11,"phoneExt":11,"email":11},"Bo Yu, MD",{"facility":134,"status":48,"city":135,"state":136,"zip":11,"country":52,"countryCode":53,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"The First Hospital of Jilin University","Changchun","Jilin",{"type":55,"coordinates":138},[139,140],125.32278,43.88,{"lat":140,"lon":139},[143,147],{"name":144,"role":42,"phone":145,"phoneExt":11,"email":146},"Qian Tong","+86-0431-81879801","tongqian@jlu.edu.cn",{"name":148,"role":34,"phone":11,"phoneExt":11,"email":11},"Qian Tong, MD",{"facility":150,"status":48,"city":151,"state":152,"zip":11,"country":52,"countryCode":53,"cosmosGeoPoint":153,"geoPoint":157,"contacts":158},"The First Affiliated Hospital of Xi'an Jiaotong University","Xi'an","Shaanxi",{"type":55,"coordinates":154},[155,156],108.92861,34.25833,{"lat":156,"lon":155},[159,163],{"name":160,"role":42,"phone":161,"phoneExt":11,"email":162},"Zuyi Yuan","+86-029-85323473","yue.wu@xjtu.edu.cn",{"name":164,"role":34,"phone":11,"phoneExt":11,"email":11},"Zuyi Yuan, MD",{"type":166,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100617257","safety-and-effectiveness-of-catheter-ablation-for-atrial-fibrillation-with-intracranial-hemorrhage-safer-af-100617257",false,"NCT07316270","SAfety and eFfectiveness of cathetER Ablation for Atrial Fibrillation With Intracranial Hemorrhage (SAFER-AF)","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Between 14 Days and 12 Months After Spontaneous Intracranial Hemorrhage (intraparenchymal or intraventricular hemorrhage, and subdural hematoma)\n3. Able to Access Intracranial Hemorrhage Imaging Data\n4. ECG indicating the presence of atrial fibrillation\n5. CHA₂DS₂-VA Score ≥ 2\n6. Willing to undergo randomization and able to complete follow-up as required\n\nExclusion Criteria:\n\n1. Atrial fibrillation secondary to clearly reversible causes (e.g., hyperthyroidism, hypokalemia, etc.)\n2. Fully dependent (modified Rankin Scale \\[mRS\\] score \\> 4)\n3. Uncontrolled hypertension (systolic blood pressure \\> 160 mmHg)\n4. Presence of uncontrolled active bleeding\n5. Presence of active infection requiring antibiotic treatment\n6. End-stage renal failure or receiving dialysis treatment\n7. Presence of liver failure\n8. Untreated coronary artery disease with indication for revascularization\n9. Presence of intracardiac masses, thrombi, etc., as evaluated by transthoracic echocardiography or transesophageal echocardiography\n10. Expected life expectancy \\\u003C 1 year (e.g., advanced malignant tumors, etc.)\n11. Pregnant, lactating, or women planning to become pregnant\n12. Presence of psychological or psychiatric disorders that prevent understanding or cooperation with the study\n13. Other conditions deemed unsuitable for participation in the study by the investigators","ALL","18 Years",{"count":176,"type":177},646,"ESTIMATED","INTERVENTIONAL",[180],"NA","SAFER-AF is an investigator-initiated, multicenter, open-label, parallel-group trial comparing catheter ablation versus usual care in patients with atrial fibrillation and intracranial hemorrhage.",[183,184],"AF - Atrial Fibrillation","Intracranial Hemorrhage, Spontaneous","2026-08-05",{"date":187,"type":188},"2026-08-07","ACTUAL",{"date":190,"type":188},"2026-05-06",{"date":192,"type":177},"2030-01",{"name":5,"class":6},7]