[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100527375":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":151,"collaborators":154,"id":166,"slug":167,"hasResults":168,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":25,"eligibilityCriteria":172,"healthyVolunteers":168,"sex":173,"minAge":174,"maxAge":175,"enrollmentInfo":176,"targetDuration":25,"studyType":179,"phases":180,"briefSummary":182,"conditions":183,"keywords":185,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":198},{"fullName":5,"class":6},"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Omitting dissection of the No.253 lymph node","EXPERIMENTAL","Perform surgery based on the principle of Total Mesorectal Excision (TME), without denuding the root of the Inferior Mesenteric Artery (IMA) and without dissection of the No.253 lymph node. Ligation of the IMA is performed at a low position distal to the origin of the left colonic artery.",[13],"Procedure: Omitting the dissection of the No.253 lymph node",{"label":15,"type":16,"description":17,"interventionNames":18},"Dissection of the No.253 lymph node","ACTIVE_COMPARATOR","Perform surgery based on the principle of Total Mesorectal Excision (TME). During the procedure, fully expose the root of the Inferior Mesenteric Artery (IMA), thoroughly dissect the No.253 lymph node, and perform a high ligation along the artery at the root of the IMA; or expose the bifurcation of the left colonic artery, ligating the IMA at a low position distal to the origin of the left colonic artery, ensuring the dissection of the No. 253 lymph node while preserving the left colonic artery.",[19],"Procedure: Dissection of the No.253 lymph node",[21,26],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","The range of the No.253 lymph node is as follows: medially, it extends from the root of the inferior mesenteric artery to the starting section of the left colonic artery; caudally, from the starting point of the left colonic artery to the intersection with the inferior mesenteric vein; laterally, it is bordered by the outer margin of the inferior mesenteric vein; and cranially, from the horizontal section of the duodenum to the beginning of the jejunum. In the controlled group, the surgery is performed with dissection of the No.253 lymph node.",[15],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Omitting the dissection of the No.253 lymph node","In the experimental group, the surgery is performed without dissection of the No.253 lymph node.",[9],[31],{"name":32,"affiliation":33,"role":34},"Qian Liu","Cancer Hospital Chinese Academy of Medical Science","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Mingguang Zhang, Dr.","CONTACT","+8613261967603","zmgslimshady@163.com",{"name":42,"role":38,"phone":43,"phoneExt":25,"email":44},"Qian Liu, Dr.","13601008906","fcwpumch@163.com",[46,65,77,88,99,111,125,136],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Peking Union Medical College Hospital","RECRUITING","Beijing","Beijing Municipality","100021","China","CN",{"type":55,"coordinates":56},"Point",[57,58],116.39723,39.9075,{"lat":58,"lon":57},[61,64],{"name":62,"role":38,"phone":63,"phoneExt":25,"email":25},"Yi Xiao, Dr.","13366036387",{"name":62,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":66,"status":67,"city":49,"state":50,"zip":68,"country":52,"countryCode":53,"cosmosGeoPoint":69,"geoPoint":71,"contacts":72},"China-Japan Friendship Hospital","NOT_YET_RECRUITING","100029",{"type":55,"coordinates":70},[57,58],{"lat":58,"lon":57},[73,76],{"name":74,"role":38,"phone":75,"phoneExt":25,"email":25},"Lei Zhou, Dr.","13910279583",{"name":74,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":78,"status":67,"city":49,"state":50,"zip":79,"country":52,"countryCode":53,"cosmosGeoPoint":80,"geoPoint":82,"contacts":83},"Beijing Cancer Hospital","100142",{"type":55,"coordinates":81},[57,58],{"lat":58,"lon":57},[84,87],{"name":85,"role":38,"phone":86,"phoneExt":25,"email":25},"Aiwen Wu, Dr.","13911577190",{"name":85,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":89,"status":67,"city":49,"state":90,"zip":91,"country":52,"countryCode":53,"cosmosGeoPoint":92,"geoPoint":94,"contacts":95},"Chinese PLA General Hospital","Beijng","100141",{"type":55,"coordinates":93},[57,58],{"lat":58,"lon":57},[96,98],{"name":97,"role":38,"phone":25,"phoneExt":25,"email":25},"Xiaohui Du, Dr.",{"name":97,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":100,"status":48,"city":49,"state":101,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":102,"geoPoint":104,"contacts":105},"Cancer Hospital Chinese Academy of Medical Sciences","Chaoyang District",{"type":55,"coordinates":103},[57,58],{"lat":58,"lon":57},[106,108,110],{"name":107,"role":38,"phone":43,"phoneExt":25,"email":44},"Qian Liu, M.D.",{"name":109,"role":38,"phone":39,"phoneExt":25,"email":40},"Mingguang Zhang, M.D.",{"name":107,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":112,"status":67,"city":113,"state":114,"zip":115,"country":52,"countryCode":53,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Ruijin Hospital, Shanghai Jiaotong University School of Medicine","Shanghai","Shanghai Municipality","200025",{"type":55,"coordinates":117},[118,119],121.45806,31.22222,{"lat":119,"lon":118},[122,124],{"name":123,"role":38,"phone":25,"phoneExt":25,"email":25},"Minhua Zheng",{"name":123,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":126,"status":48,"city":113,"state":114,"zip":127,"country":52,"countryCode":53,"cosmosGeoPoint":128,"geoPoint":130,"contacts":131},"Fudan University Shanghai Cancer Center","200032",{"type":55,"coordinates":129},[118,119],{"lat":119,"lon":118},[132,134],{"name":133,"role":38,"phone":25,"phoneExt":25,"email":25},"Xinxiang Li, Dr.",{"name":135,"role":34,"phone":25,"phoneExt":25,"email":25},"Xinxiang Li",{"facility":137,"status":67,"city":138,"state":139,"zip":140,"country":52,"countryCode":53,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"West China Hospital Sichuan University","Chengdu","Sichuan","610044",{"type":55,"coordinates":142},[143,144],104.06667,30.66667,{"lat":144,"lon":143},[147,149],{"name":148,"role":38,"phone":25,"phoneExt":25,"email":25},"Ziqiang Wang, Dr.",{"name":150,"role":34,"phone":25,"phoneExt":25,"email":25},"Ziqiang Wang",{"type":34,"investigatorFullName":152,"investigatorTitle":153,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"QIAN LIU","Professor",[155,156,157,158,160,162,164],{"name":47,"class":6},{"name":66,"class":6},{"name":89,"class":6},{"name":159,"class":6},"Ruijin Hospital",{"name":161,"class":6},"Fudan University",{"name":163,"class":6},"West China Hospital",{"name":165,"class":6},"Peking University Cancer Hospital & Institute","100527375","safety-of-mid-and-low-rectal-cancer-surgery-without-dissection-of-the-no253-lymph-node-s-m-o-o-t-h-100527375",false,"NCT06146946","Safety of Mid and Low Rectal Cancer Surgery Without Dissection of the No.253 Lymph Node (S-M-O-O-T-H)","Safety of Mid and Low Rectal Cancer Surgery Without Dissection of the No.253 Lymph Node, a Prospective, Multicenter, Non-inferior Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patient age between 18-75 years.\n2. Colonic biopsy pathology confirms adenocarcinoma.\n3. At initial treatment, colonoscopy and imaging diagnose the tumor's lower edge as less than or equal to 7cm from the anus.\n4. At initial treatment, imaging diagnoses the tumor T stage as less than or equal to 3.\n5. At initial treatment, imaging diagnoses no enlarged lymph nodes at the root of the inferior mesenteric artery.\n6. At initial treatment, imaging diagnoses the number of mesenteric metastatic lymph nodes as less than or equal to three.\n7. Strong willingness for surgery and signed informed consent.\n\nExclusion Criteria:\n\n1. Previous history of malignant colorectal tumors.\n2. Colonic biopsy pathology reveals mucinous adenocarcinoma or signet ring cell carcinoma.\n3. Imaging diagnosis of distant metastasis.\n4. Patients who have undergone multiple abdominal-pelvic surgeries or have extensive abdominal adhesions.\n5. Patients with complications such as intestinal obstruction, intestinal perforation, or intestinal bleeding requiring emergency surgery.\n6. Extensive lesions not amenable to R0 resection.\n7. Diagnosed with other malignancies within the past five years.\n8. ASA (American Society of Anesthesiologists) classification ≥ IV and\u002For ECOG (Eastern Cooperative Oncology Group) performance status score ≥ 2.\n9. Patients with severe liver, kidney, cardiac, pulmonary, coagulation dysfunctions, or serious underlying diseases that cannot tolerate surgery.\n10. History of severe mental illness.\n11. Pregnant or breastfeeding women.","ALL","18 Years","75 Years",{"count":177,"type":178},1384,"ESTIMATED","INTERVENTIONAL",[181],"NA","The goal of this clinical trial is to learn about whether it is safe to omit dissection of the No.253 lymph nodes in mid and low rectal cancer surgery. The main question it aims to answer is that if it is possible to achieve the same long-term survival with and without the dissection of the No.253 lymph node in mid and low rectal cancer surgery. Participants will underwent laparoscopic rectal radical resection with or without the dissection of the No.253 lymph node.",[184],"Rectal Cancer",[186,187,188],"Rectal cancer","Lymph node dissection","No.253 lymph node","2026-07-30",{"date":191,"type":192},"2026-07-31","ACTUAL",{"date":194,"type":192},"2023-12-01",{"date":196,"type":178},"2029-12-01",{"name":5,"class":6},8]