[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645716":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":10,"centralContacts":34,"locations":40,"responsibleParty":55,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":10,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Necmettin Erbakan University","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Periodontally Healthy Systemically Healthy Group",null,"Periodontally healthy individuals without type 2 diabetes mellitus or other systemic diseases.",[13],"Diagnostic Test: Salivary Biomarker Analysis",{"label":15,"type":10,"description":16,"interventionNames":17},"Periodontally Healthy Type 2 Diabetes Group","Periodontally healthy individuals diagnosed with type 2 diabetes mellitus.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Periodontitis Systemically Healthy Group","Systemically healthy individuals diagnosed with generalized Stage II or Stage III periodontitis according to the 2017 World Workshop Classification.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Periodontitis Type 2 Diabetes Group","Individuals diagnosed with both generalized Stage II or Stage III periodontitis and type 2 diabetes mellitus.",[13],[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DIAGNOSTIC_TEST","Salivary Biomarker Analysis","Unstimulated saliva samples will be collected from participants before periodontal treatment and before periodontal probing. Salivary apelin, chemerin, ghrelin, and lipocalin-2 levels will be measured using enzyme-linked immunosorbent assay kits according to the manufacturer's instructions. This procedure is used for biomarker assessment only and does not involve any therapeutic intervention.",[9,15,19,23],[33],"ELISA-based salivary biomarker measurement",[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Osman Babayiğit","CONTACT","+90 506 320 84 74","obabayigit@erbakan.edu.tr",[41],{"facility":42,"status":43,"city":44,"state":44,"zip":45,"country":46,"countryCode":10,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Necmettin Erbakan University Faculty of Dentistry, Department of Periodontology","RECRUITING","Konya","42090","Turkey (Türkiye)",{"type":48,"coordinates":49},"Point",[50,51],32.48464,37.87135,{"lat":51,"lon":50},[54],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Osman Babayigit","Principal Investigator","100645716","salivary-apelin-chemerin-ghrelin-and-lipocalin-2-levels-in-diabetic-patients-with-periodontitis-100645716",false,"NCT07703345","Salivary Apelin, Chemerin, Ghrelin, and Lipocalin-2 Levels in Diabetic Patients With Periodontitis","Evaluation of Salivary Apelin, Chemerin, Ghrelin and Lipocalin 2 Levels in Diabetic Patients With Periodontitis","Inclusion Criteria:\n\n* Individuals aged 18 to 80 years. Individuals who apply to the Department of Periodontology, Faculty of Dentistry, Necmettin Erbakan University.\n\nIndividuals who agree to participate in the study and sign the informed consent form.\n\nPresence of at least 20 teeth. For the periodontally healthy groups: diagnosis of periodontal health based on routine clinical and radiographic examination.\n\nFor the periodontitis groups: diagnosis of generalized Stage II or Stage III periodontitis based on routine clinical and radiographic examination according to the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions.\n\nFor the type 2 diabetes mellitus groups: diagnosis of type 2 diabetes mellitus. For the systemically healthy groups: absence of systemic diseases, including type 2 diabetes mellitus.\n\nExclusion Criteria:\n\n* Periodontal treatment, including scaling and root surface debridement, within the last 6 months.\n\nAntibiotic use within the last 6 months. Pregnancy or lactation. Presence of autoimmune diseases such as rheumatoid arthritis, familial Mediterranean fever, ankylosing spondylitis, Behçet disease, or psoriasis.\n\nPresence of systemic diseases other than type 2 diabetes mellitus in the diabetes groups.\n\nPresence of systemic diseases such as nephrotic syndrome, chronic renal disease, or cardiovascular disease.\n\nSmoking 10 or more cigarettes per day.",true,"ALL","18 Years","80 Years",{"count":71,"type":72},88,"ESTIMATED","OBSERVATIONAL","This observational cross-sectional study will evaluate salivary apelin, chemerin, ghrelin, and lipocalin-2 levels in individuals with different periodontal and systemic conditions. Participants will be divided into four groups according to periodontal status and the presence or absence of type 2 diabetes mellitus.\n\nClinical periodontal measurements and unstimulated saliva samples will be obtained before periodontal treatment. Salivary biomarker levels will be measured using enzyme-linked immunosorbent assay kits. The study aims to determine whether salivary apelin, chemerin, ghrelin, and lipocalin-2 levels are associated with periodontitis, type 2 diabetes mellitus, and periodontal clinical parameters.",[76,77],"Periodontitis","Type 2 Diabetes Mellitus (T2DM)",[76,79,80,81,82],"Type 2 Diabetes Mellitus","Salivary Biomarkers","Apelin","Chemerin","2026-07-09",{"date":85,"type":86},"2026-07-14","ACTUAL",{"date":88,"type":86},"2026-07-01",{"date":90,"type":72},"2026-08-01",{"name":5,"class":6},1]