[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658368":3},{"organization":4,"outcomesModule":7,"designInfo":20,"detailedDescription":27,"studyPopulation":19,"armGroups":28,"interventions":40,"overallOfficials":19,"centralContacts":47,"locations":53,"responsibleParty":73,"collaborators":19,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":19,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":19,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":55,"whyStopped":19,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of Michigan","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":19},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Strength - Maximal Voluntary Contraction (MVC)","Changes in MVC after 8 weeks resistance training. MVC is the greatest force generated during a brief isometric contraction.","One session before and then after 8 weeks of training",{"measure":14,"description":15,"timeFrame":12},"Fatigability - Reduction in Power","Reduction in limb power and maximal force in response to a dynamic fatiguing contraction.",{"measure":17,"description":18,"timeFrame":12},"Strength - 1 Repetition Maximum","Reduction in limb power and maximal force in response to a dynamic fatiguing contraction",null,{"allocation":21,"interventionModel":22,"interventionModelDescription":23,"primaryPurpose":24,"observationalModel":19,"timePerspective":19,"maskingInfo":25},"NON_RANDOMIZED","PARALLEL","Each participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.","BASIC_SCIENCE",{"masking":26,"maskingDescription":19,"whoMasked":19},"NONE","The primary objective of the research is to and evaluate how hormonal status influences the neural and muscular drivers of strength and fatigue, which we have divided into two central Aims. Aim 1 will assess baseline differences in neuromuscular function between HT females and non-HT females. In Aim 2, participants will complete an 8-week high-resistance training program to evaluate the effects of sex and HT on neuromuscular adaptations.\n\nAt the University of Michigan, populations recruited will include:\n\n1. 60 healthy older females who have not used any form of HT\n2. 60 healthy older females who have been prescribed HT by their physician",[29,35],{"label":30,"type":31,"description":32,"interventionNames":33},"Postmenopausal Hormone Therapy","EXPERIMENTAL","Postmenopausal females who are currently taking hormone replacement therapy",[34],"Other: HRT: High-Resistance Strength Training",{"label":36,"type":31,"description":37,"interventionNames":38},"Postmenopausal Female Controls","Postmenopausal females who have no history of taking hormone replacement therapy",[39],"Other: Control: High-Resistance Strength Training",[41,44],{"type":6,"name":42,"description":23,"armGroupLabels":43,"otherNames":19},"HRT: High-Resistance Strength Training",[30],{"type":6,"name":45,"description":23,"armGroupLabels":46,"otherNames":19},"Control: High-Resistance Strength Training",[36],[48],{"name":49,"role":50,"phone":51,"phoneExt":19,"email":52},"Sandra Hunter, PhD","CONTACT","(734) 647-9819","sandrahu@umich.edu",[54],{"facility":5,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Ann Arbor","Michigan","48109","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-83.74088,42.27756,{"lat":65,"lon":64},[68,70],{"name":49,"role":50,"phone":69,"phoneExt":19,"email":52},"(734) 647-6019",{"name":71,"role":50,"phone":19,"phoneExt":69,"email":72},"Sarah Lessila, MS","slessila@umich.edu",{"type":74,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Sandra Hunter","Francie Kraker Goodridge Collegiate Professor of Kinesiology and Professor of Kinesiology, School of Kinesiology","100658368","sex-hormones-and-aging-100658368",false,"NCT07848438","Sex Hormones and Aging","Hormone-Related Mechanisms of Neuromuscular Aging and Exercise Adaptation","Inclusion Criteria:\n\nExclusion Criteria:\n\n* Females who are pregnant or likely to be pregnant. Female subjects of childbearing age will be asked of the possibility of pregnancy and will be excluded from the study if they are pregnant or become pregnant during the study.\n* Females who are not currently taking HT but have taken HT in the past 5 years.\n* Severe obesity (body mass index, BMI, \\> 45 kg\u002Fm2): this will be calculated from measured height and weight\n* Untreated hypothyroidism\n* Uncontrolled blood pressure (\\>160\u002F100 mmHg at rest)\n* Epilepsy or increased risk of seizures\n* Metal implants in the body, excluding the mouth\n* Head injury in the past 6 months\n* People who are taking any of the following medications: Medications that affect cortical excitability, Nonsteroidal anti-inflammatory drug (NSAID) use in the past 24 hours or chronic use of NSAIDs, Beta blockers or any other heart rate stabilizing medications, Any neurological, cardiovascular or musculoskeletal disease that precludes exercise testing",true,"FEMALE","50 Years","70 Years",{"count":89,"type":90},120,"ESTIMATED","INTERVENTIONAL",[93],"NA","This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training.\n\nAge-related declines in neuromuscular function are especially pronounced in females, potentially due to the sharp drop in estradiol after menopause. This project will compare postmenopausal females who have not taken hormonal therapy (HT) to age-matched females taking HT.",[96,97,98],"Menopause","Menopausal Hormone Therapy","Aging",[96,97,100],"Hormone Replacement Therapy","2026-09-23",{"date":103,"type":104},"2026-09-30","ACTUAL",{"date":106,"type":104},"2026-08-20",{"date":108,"type":90},"2031-08",{"name":5,"class":6},1]