[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654901":3},{"organization":4,"outcomesModule":7,"designInfo":84,"detailedDescription":87,"studyPopulation":87,"armGroups":91,"interventions":101,"overallOfficials":87,"centralContacts":106,"locations":113,"responsibleParty":130,"collaborators":134,"id":144,"slug":145,"hasResults":146,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":146,"sex":152,"minAge":153,"maxAge":154,"enrollmentInfo":155,"targetDuration":87,"studyType":158,"phases":159,"briefSummary":161,"conditions":162,"keywords":164,"overallStatus":116,"whyStopped":87,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":175},{"fullName":5,"class":6},"Universidad de León","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":23,"otherOutcomes":39},[9,13,16,20],{"measure":10,"description":11,"timeFrame":12},"Change in Symbol Digit Modalities Test Oral Score","Cognitive processing speed will be assessed through the oral version of the Symbol Digit Modalities Test (SDMT). The outcome will be reported as the total number of correct responses. Scores range from 0 to 110, with higher scores indicating better cognitive processing speed. Change from baseline to Week 4 will be evaluated.","Baseline and Week 4",{"measure":14,"description":15,"timeFrame":12},"Change in Fatigue Severity Scale Score","Fatigue severity will be assessed through the Fatigue Severity Scale (FSS). The FSS includes 9 items, each scored from 1, indicating strongly disagree, to 7, indicating strongly agree. The total score is calculated as the mean of the 9 items and ranges from 1 to 7, with higher scores indicating greater fatigue severity. Change from baseline to Week 4 will be evaluated.",{"measure":17,"description":18,"timeFrame":19},"Change in Timed 25 Foot Walk Time","Walking speed will be assessed through the Timed 25-Foot Walk (T25FW). This test will be performed forwards and backwards, at a comfortable pace and as fast as safely possible, with 2 trials for each condition. Time will be recorded in seconds using a stopwatch. The outcome will be reported as the lowest time recorded for each condition, with lower times indicating a faster walking speed. Change from baseline to Week 4 will be evaluated.","Baseline to Week 4",{"measure":21,"description":22,"timeFrame":12},"Change in the Six-Spot Step Test Time","Dynamic walking performance and lower-limb coordination will be assessed through the Six-Spot Step Test (SSST). The SSST will be performed after a familiarization trial as fast as safely possible for two trials with each leg. Time will be recorded in seconds using a stopwatch, with lower times indicating better lower-limb coordination and walking performance. The outcome will be reported as the lowest time recorded for each leg. Change from baseline to Week 4 will be evaluated.",[24,27,30,33,36],{"measure":25,"description":26,"timeFrame":12},"Change in Handgrip Strength","Handgrip strength will be assessed using a hand dynamometer and recorded in kg. The outcome will be the best of 3 trials, with higher scores indicating greater handgrip strength. Change from baseline to Week 4 will be evaluated.",{"measure":28,"description":29,"timeFrame":19},"Change in Lower-limb Muscle Power","Lower-limb muscle power will be assessed through the 5-repetition Sit-to-Stand test (5-STS) with the time recorded in seconds with a stopwatch. The outcome will be reported as the best of the 2 trials, with lower times indicating greater muscle power. Change from baseline to Week 4 will be evaluated.",{"measure":31,"description":32,"timeFrame":19},"Change in Lower-limb endurance and strength","Lower-limb endurance and strength will be assessed through the 30-second Sit-to-Stand test (30-STS), with the number of repetitions visually counted. The outcome will be reported as the best of 2 trials, with a higher number of repetitions indicating greater lower-limb endurance and strength. Change from baseline to Week 4 will be evaluated.",{"measure":34,"description":35,"timeFrame":12},"Change in Cardiorespiratory fitness","Cardiorespiratory fitness will be assessed using the Young Men's Christian Association 3-minute step test (YMCA step test). Heart rate will be assessed with a chest strap heart-rate monitor. The outcome will be recorded as the mean recovery heart rate after 60 s of rest, with lower scores indicating better cardiorespiratory fitness. Change from baseline to Week 4 will be evaluated.",{"measure":37,"description":38,"timeFrame":19},"Change in Plantar flexor strength-endurance","Plantar flexor strength-endurance will be assessed using the standing single-leg heel-rise test. The outcome will be reported as the number of repetitions visually counted from each leg in 1 trial, with a higher number of repetitions indicating greater plantar flexor endurance capacity. Change from baseline to Week 4 will be evaluated.",[40,44,47,50,54,58,61,65,67,69,72,74,76,78,80,82],{"measure":41,"description":42,"timeFrame":43},"Cadence during the intervention sessions","Data will be recorded during each intervention session and will be used as descriptive data.\n\nCadence will be recorded using the potentiometer of the recumbent cycle ergometer by a custom software app in revolutions per minute.","During each sprint interval training session, up to 2 weeks",{"measure":45,"description":46,"timeFrame":43},"Heart rate during the intervention sessions","Data will be recorded during each intervention session and will be used as descriptive data.\n\nHeart rate will be recorded using the handheld sensors of the recumbent cycle ergometer by a custom software app in beats per minute.",{"measure":48,"description":49,"timeFrame":43},"Power during intervention sessions","Data will be recorded during each intervention session and will be used as descriptive data.\n\nPower output will be recorded using the potentiometer of the recumbent cycle ergometer by a custom software app in watts.",{"measure":51,"description":52,"timeFrame":53},"Rating of Perceived Exertion After Each Sprint","Rating of perceived exertion (RPE) will be assessed using the Borg Category-Ratio 10 scale (CR10). Scores range from 0 to 10, with 0 indicating rest and 10 indicating maximal effort. The outcome will be reported as the perceived exertion score recorded after each sprint, with lower scores indicating lower perceived exertion.","After each sprint during each sprint interval training session, up to 2 weeks",{"measure":55,"description":56,"timeFrame":57},"Session Rating of Perceived Exertion","Global session rating of perceived exertion (sRPE) will be assessed after each exercise session using the Borg Category-Ratio 10 scale (CR10). Scores ranges from 0 to 10, with 0 indicating rest and 10 indicating maximal effort. The outcome will be reported as the session perceived exertion score, with lower scores indicating lower perceived exertion.","After each exercise session during the 2-week intervention period",{"measure":59,"description":60,"timeFrame":53},"Affective Valence After Each Sprint","Affective valence will be assessed after every sprint in the short sprint interval training intervention using the Feeling Scale. This scale ranges from -5 to +5, with +5 indicating very good, 0 indicating neutral, and -5 indicating very bad. The outcome will be reported as the affective valence score, with higher scores indicating better affective valence.",{"measure":62,"description":63,"timeFrame":64},"Descriptive and anthropometric data","Height measured in meters.","Baseline",{"measure":62,"description":66,"timeFrame":64},"Body mass measured in kilograms.",{"measure":62,"description":68,"timeFrame":64},"Body mass index measured through the combination of weight and height reported in kg\u002Fm\\^2.",{"measure":70,"description":71,"timeFrame":64},"Descriptive and anthropometric data.","Waist circumference and Hip circumference will be measured in centimeters.",{"measure":62,"description":73,"timeFrame":64},"Waist circumference and Hip circumference will be combined to report Waist-to-hip ratio as an index.",{"measure":62,"description":75,"timeFrame":64},"Smoking status will be reported by the patient with yes or no.",{"measure":62,"description":77,"timeFrame":64},"Most affected side will be reported by the patient as left, right, or both.",{"measure":70,"description":79,"timeFrame":64},"Limb dominance will be reported by the patient as left, right, or ambidextrous.",{"measure":70,"description":81,"timeFrame":64},"Patient-reported walking ability over the previous 2 weeks will be assessed using the 12-Item Multiple Sclerosis Walking Scale (MSWS-12). Items are scored on a Likert scale from 1 to 5, with 1 indicating \"Not at all\" and 5 indicating \"Extremely\". Scores range from 12 to 60 and are transformed into a percentage. The outcome will be reported as the percentage, with higher percentages indicating a greater perceived impact of MS on walking.",{"measure":70,"description":83,"timeFrame":64},"Fatigue over the previous 4 weeks will be assessed using the Modified Fatigue Impact Scale (MFIS). Items are scored on a Likert scale from 0 to 4, with 0 indicating \"Never\" and 4 indicating \"Almost always\". Total scores range from 0 to 84. The outcome will be reported as the total score, with higher scores indicating a greater impact of fatigue.",{"allocation":85,"interventionModel":86,"interventionModelDescription":87,"primaryPurpose":88,"observationalModel":87,"timePerspective":87,"maskingInfo":89},"RANDOMIZED","PARALLEL",null,"SUPPORTIVE_CARE",{"masking":90,"maskingDescription":87,"whoMasked":87},"NONE",[92,97],{"label":93,"type":94,"description":87,"interventionNames":95},"Short Sprint Interval Training Intervention Group","EXPERIMENTAL",[96],"Other: Short sprint interval training",{"label":98,"type":99,"description":100,"interventionNames":87},"Usual Physical Activity Control Group","NO_INTERVENTION","Participants in this arm will not receive any intervention and will be asked to continue their usual physical activity during the 2-week study period.",[102],{"type":6,"name":103,"description":104,"armGroupLabels":105,"otherNames":87},"Short sprint interval training","Participants will perform a supervised short sprint interval training program on a recumbent cycle ergometer for 2 weeks, with 3 sessions per week. Each session will include a 5-minute warm-up at an easy intensity, followed by repeated 5-second high-intensity cycling sprints separated by 40 seconds of active recovery. The number of sprints will increase progressively across sessions from 5 to 9, with a reduced number of sprints in the final session.",[93],[107],{"name":108,"role":109,"phone":110,"phoneExt":111,"email":112},"Daniel Alexandre Boullosa Álvarez","CONTACT","+34 987 29 30 00","56","dboua@unileon.es",[114],{"facility":115,"status":116,"city":117,"state":118,"zip":119,"country":120,"countryCode":121,"cosmosGeoPoint":122,"geoPoint":127,"contacts":128},"Ule Motion Lab","RECRUITING","Ponferrada","León","24416","Spain","ES",{"type":123,"coordinates":124},"Point",[125,126],-6.59619,42.54664,{"lat":126,"lon":125},[129],{"name":108,"role":109,"phone":110,"phoneExt":111,"email":112},{"type":131,"investigatorFullName":132,"investigatorTitle":133,"investigatorAffiliation":5,"oldNameTitle":87,"oldOrganization":87},"PRINCIPAL_INVESTIGATOR","Daniel Boullosa","\"Ramón y Cajal\" Fellow",[135,137,140,142],{"name":136,"class":6},"Hasselt University",{"name":138,"class":139},"University of Leon","UNKNOWN",{"name":141,"class":139},"El Bierzo Hospital",{"name":143,"class":139},"Sil Multiple Sclerosis Association","100654901","short-sprint-interval-training-in-people-with-multiple-sclerosis-100654901",false,"NCT07804264","Short Sprint Interval Training in People With Multiple Sclerosis","Short Sprint Interval Training as an Effective Exercise Strategy for People With Multiple Sclerosis","sSIT-MS","Inclusion Criteria:\n\n* Diagnosis of multiple sclerosis according to the revised McDonald criteria; Expanded Disability Status Scale score 0-3.5.\n* Age 18-65 years.\n* No multiple sclerosis relapse or exacerbation in the previous month.\n\nExclusion Criteria:\n\n* Neurological disease other than multiple sclerosis.\n* Cognitive impairment preventing completion of tests or questionnaires.\n* Neurological, orthopedic, or visual impairments affecting gait.","ALL","18 Years","65 Years",{"count":156,"type":157},40,"ESTIMATED","INTERVENTIONAL",[160],"NA","The goal of this clinical trial is to learn whether a short sprint interval training protocol on a cycle ergometer can improve physical function, walking, muscle strength, exercise capacity, fatigue, cognitive processing speed, and patient-reported outcomes in people with multiple sclerosis.\n\nThe main questions it aims to answer are:\n\n1. Does short sprint interval training improve walking performance, lower-limb coordination, muscle strength, exercise capacity, fatigue, and cognitive processing speed in people with multiple sclerosis?\n2. How do participants respond to short sprint interval training in terms of heart rate, power, cadence, perceived exertion, and affective valence?\n3. What adverse events or unintended effects, if any, occur during the intervention?\n\nResearchers will compare short sprint interval training with usual physical activity to see if this exercise program improves physical, cognitive, and patient-reported outcomes.\n\nParticipants will:\n\n1. Be randomly assigned to either a short sprint interval training group or a usual physical activity group.\n2. Complete assessments before and after the 2-week training period.\n3. Continue their usual physical activity if they are assigned to the control group.\n4. Complete 6 supervised exercise sessions over 2 weeks if they are assigned to the short sprint interval training group.\n5. During each exercise session, perform short 5-second high-intensity cycling sprints on a recumbent cycle ergometer, separated by recovery periods.\n6. Complete walking, strength, stepping, calf endurance, fatigue, and cognitive processing speed assessments.",[163],"Multiple Sclerosis",[165,103],"Multiple sclerosis","2026-08-31",{"date":168,"type":169},"2026-09-04","ACTUAL",{"date":171,"type":157},"2026-09",{"date":173,"type":157},"2026-10",{"name":5,"class":6},1]