[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656546":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":36,"studyPopulation":37,"armGroups":38,"interventions":32,"overallOfficials":32,"centralContacts":45,"locations":51,"responsibleParty":62,"collaborators":32,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":32,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":32,"studyType":79,"phases":32,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":88,"whyStopped":32,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Inonu University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":32},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Change in Peri-Implant Crevicular Fluid RANKL Level","Receptor activator of nuclear factor kappa-B ligand (RANKL) levels in peri-implant crevicular fluid (PICF) will be measured using enzyme-linked immunosorbent assay (ELISA) and compared between short and standard implant groups.","Baseline; 1 and 3 months after non-surgical peri-implant therapy in participants who develop peri-implant mucositis.",{"measure":14,"description":15,"timeFrame":12},"Change in Peri-Implant Crevicular Fluid OPG Level","Osteoprotegerin (OPG) levels in peri-implant crevicular fluid (PICF) will be measured using enzyme-linked immunosorbent assay (ELISA) and compared between short and standard implant groups.",{"measure":17,"description":18,"timeFrame":12},"Change in Peri-Implant Crevicular Fluid Cathepsin K Level","Cathepsin K levels in peri-implant crevicular fluid (PICF) will be measured using enzyme-linked immunosorbent assay (ELISA) and compared between short and standard implant groups.",[20,23,26,29],{"measure":21,"description":22,"timeFrame":12},"Change in Peri-Implant Probing Depth","Peri-implant probing depth (PPD) will be measured in millimeters using a periodontal probe at six sites around each implant and compared between short and standard implant groups.",{"measure":24,"description":25,"timeFrame":12},"Change in Peri-Implant Bleeding on Probing","Bleeding on probing (BOP) will be assessed following gentle probing around each implant and recorded as the percentage of sites exhibiting bleeding.",{"measure":27,"description":28,"timeFrame":12},"Change in Peri-Implant Plaque Index","Peri-implant plaque accumulation will be evaluated using the Plaque Index (PI) and compared between short and standard implant groups.",{"measure":30,"description":31,"timeFrame":12},"Change in Gingival Index","Peri-implant soft tissue inflammation will be evaluated using the Gingival Index (mGI) and compared between short and standard implant groups.",null,{"allocation":32,"interventionModel":32,"interventionModelDescription":32,"primaryPurpose":32,"observationalModel":34,"timePerspective":35,"maskingInfo":32},"COHORT","PROSPECTIVE","This is a prospective study enrolling approximately 40 patients who will receive a total of 80 dental implants, categorized as short (≤6 mm) or standard (\\>8 mm) in length. Peri-implant crevicular fluid (PICF) samples will be collected at baseline from all patients. In patients who develop peri-implant mucositis, an additional PICF sample will be collected at 1 and 3 months. PICF samples will be analyzed by ELISA for RANKL, OPG, cathepsin-K, and cytokine levels. Implant diameter and length will be recorded for each patient. Clinical parameters of peri-implant tissue health will also be assessed at each visit. The study aims to compare biochemical and clinical outcomes between short and standard implants to determine whether implant length influences peri-implant tissue health.","Adult patients presenting to the Department of Periodontology, Faculty of Dentistry, Inonu University, for routine dental check-up, who have at least one short (≤6 mm) and\u002For standard (\\>8 mm) dental implant in function for at least 2 years.",[39,42],{"label":40,"type":32,"description":41,"interventionNames":32},"Short implant group","Patients receiving dental implants with a length of 6 mm or less. Peri-implant crevicular fluid (PICF) samples will be collected to assess RANKL, OPG, and cathepsin-K levels, along with clinical peri-implant tissue health parameters",{"label":43,"type":32,"description":44,"interventionNames":32},"Standard Implant Group","Patients receiving dental implants with a length greater than 8 mm. Peri-implant crevicular fluid (PICF) samples will be collected to assess RANKL, OPG, and cathepsin-K levels, along with clinical peri-implant tissue health parameters.",[46],{"name":47,"role":48,"phone":49,"phoneExt":32,"email":50},"Kubra Aral","CONTACT","05330578801","drkubraaral@gmail.com",[52],{"facility":53,"status":32,"city":54,"state":32,"zip":32,"country":55,"countryCode":32,"cosmosGeoPoint":56,"geoPoint":61,"contacts":32},"Inonu University Faculty of Dentistry","Malatya","Turkey (Türkiye)",{"type":57,"coordinates":58},"Point",[59,60],38.31667,38.35018,{"lat":60,"lon":59},{"type":63,"investigatorFullName":47,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Associate Professor, Department of Periodontology, Faculty of Dentistry","100656546","short-versus-standard-dental-implants-clinical-and-biomarker-outcomes-100656546",false,"NCT07828067","Short Versus Standard Dental Implants: Clinical and Biomarker Outcomes","Comparison of Peri-Implant Tissue Health and Biomarker Outcomes Between Short and Standard Dental Implants: A Prospective Study","Inclusion Criteria:\n\n* Systemically healthy adults aged 18-70 years.\n* Presence of at least one short (≤6 mm) and\u002For standard (\\>8 mm) dental implant in function for at least 2 years.\n* Patients presenting to the Department of Periodontology, Faculty of Dentistry, Inonu University, for routine dental examination.\n* For the peri-implant health group: absence of clinical signs of inflammation (redness, edema, or suppuration), absence of bleeding on probing (BOP), probing pocket depth (PPD) ≤5 mm, full-mouth BOP \\\u003C10%, no radiographic evidence of pathological peri-implant bone loss, and no clinical implant mobility.\n* For the peri-implant mucositis group: presence of clinical signs of inflammation (redness and\u002For edema) without suppuration, presence of bleeding on probing (BOP), probing pocket depth (PPD) ≤5 mm, full-mouth BOP \\>10%, no radiographic evidence of pathological peri-implant bone loss, and no clinical implant mobility.\n\nExclusion Criteria:\n\n* Age younger than 18 years or older than 70 years.\n* Presence of any systemic disease.\n* Immune system disorders or use of immunosuppressive medications.\n* Requirement for antibiotic prophylaxis before dental procedures.\n* Bisphosphonate therapy for osteoporosis.\n* Pregnancy or lactation.\n* Smoking.\n* Alcohol consumption.\n* Antibiotic treatment within the previous 6 months.\n* Continuous use of systemic medications.",true,"ALL","18 Years","70 Years",{"count":77,"type":78},40,"ESTIMATED","OBSERVATIONAL","This study compares two types of dental implants, short implants (6 millimeters or less in length) and standard implants (longer than 8 millimeters), to evaluate their effect on the health of the gum and bone tissue surrounding the implant. Approximately 40 patients receiving a total of 80 dental implants will be followed. Researchers will assess clinical signs of gum health around the implants, measure specific protein levels (biomarkers) in the fluid surrounding the implants associated with gum disease. The goal of this study is to determine whether implant length affects the risk of inflammation or infection around dental implants, which may help guide treatment decisions in the future.",[82],"Peri-Implant Mucositis",[84,85,86,87],"Short Dental Implants","Standard Dental Implants","Peri-Implant Tissue Health","Peri-Implant Crevicular Fluid","NOT_YET_RECRUITING","2026-09-15",{"date":91,"type":92},"2026-09-18","ACTUAL",{"date":94,"type":78},"2026-09-20",{"date":96,"type":78},"2026-12-30",{"name":5,"class":6},1]