[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658976":3},{"organization":4,"outcomesModule":7,"designInfo":13,"detailedDescription":19,"studyPopulation":11,"armGroups":20,"interventions":27,"overallOfficials":37,"centralContacts":41,"locations":46,"responsibleParty":61,"collaborators":11,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":11,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":11,"enrollmentInfo":72,"targetDuration":11,"studyType":75,"phases":76,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":49,"whyStopped":11,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Mahidol University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"To determine the prevalence of shrimp sensitization and clinical shrimp allergy among patients with a history of edible insect allergy.",null,"Up to 4 weeks",{"allocation":14,"interventionModel":15,"interventionModelDescription":11,"primaryPurpose":16,"observationalModel":11,"timePerspective":11,"maskingInfo":17},"NA","SINGLE_GROUP","DIAGNOSTIC",{"masking":18,"maskingDescription":11,"whoMasked":11},"NONE","A cross-sectional study of 19 patients aged ≥7 years with confirmed edible insect allergy. Participants will undergo comprehensive allergy assessment, including skin prick testing, specific IgE, tropomyosin, ALEX2, and immunoblot analysis. Risk-based oral food challenges to edible insects and white shrimp will be performed when clinically appropriate. The study aims to characterize shrimp sensitization, confirmed shrimp allergy, and clinical and molecular cross-reactivity between edible insects and shrimp",[21],{"label":22,"type":6,"description":23,"interventionNames":24},"Patients with Edible Insect Allergy","Patients aged ≥7 years with confirmed edible insect allergy will undergo allergy assessment, including skin prick testing, specific IgE testing, ALEX2, immunoblot analysis, and oral food challenges to edible insects and\u002For white shrimp when clinically appropriate.",[25,26],"Dietary Supplement: Edible Insect Oral Food Challenge","Dietary Supplement: White Shrimp Oral Food Challenge",[28,33],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"DIETARY_SUPPLEMENT","Edible Insect Oral Food Challenge","Participants with suspected edible insect allergy who do not have a history of anaphylaxis or a previous positive oral food challenge will undergo an oral food challenge to the implicated edible insect (silkworm, bamboo worm, or palm weevil). The challenge will be performed using a graded protocol under medical supervision. Participants will be observed for at least 120 minutes after completion of the challenge.",[22],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"White Shrimp Oral Food Challenge","Participants with confirmed edible insect allergy will undergo a risk-based oral food challenge to white shrimp when clinically appropriate. Participants with previous tolerance will receive a single-step challenge with 100% of the age-appropriate serving, whereas those who have never consumed white shrimp or have a history of mild reactions will undergo a 4-step graded challenge (1\u002F12, 1\u002F6, 1\u002F4, and 1\u002F2 of the total serving). Participants with a history of white shrimp anaphylaxis or a white shrimp SPT wheal \\>22.5 mm will not undergo the challenge. Participants will be observed for at least 120 minutes after the challenge",[22],[38],{"name":39,"affiliation":5,"role":40},"Punchama Pacharn","PRINCIPAL_INVESTIGATOR",[42],{"name":39,"role":43,"phone":44,"phoneExt":11,"email":45},"CONTACT","024197000 Ext. 5670","punchama@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":11},"Siriraj hospital","RECRUITING","Bangkok","Bangkoknoi","10700","Thailand","TH",{"type":56,"coordinates":57},"Point",[58,59],100.50144,13.75398,{"lat":59,"lon":58},{"type":62,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100658976","shrimp-sensitization-and-allergy-among-patients-with-edible-insect-allergy-100658976",false,"NCT07857187","Shrimp Sensitization and Allergy Among Patients With Edible Insect Allergy","Inclusion Criteria:\n\n* Patients aged 7 years or older with a history of allergy to one or more of the following edible insects: silkworm, bamboo worm, or palm weevil.\n* Patients with a history of an acute allergic reaction to silkworm, bamboo worm, or sago palm weevil who meet at least one of the following criteria:\n\n  1. Development of clinical symptoms consistent with an acute allergic reaction within 2 hours after ingestion of the implicated edible insect, with evidence of sensitization confirmed by a positive skin prick test (SPT) to that edible insect; or\n  2. A positive oral food challenge (OFC) to the edible insect previously associated with allergic symptoms (silkworm, bamboo worm, or sago palm weevil).\n\nExclusion Criteria:\n\n* Scombroidosis (histamine fish poisoning).\n* Currently receiving allergen immunotherapy.\n* Unable to comply with the study follow-up schedule.\n* Uncontrolled or severe asthma.\n* Cardiovascular disease.\n* Current use of beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs).\n* Developmental delay or intellectual disability.",true,"ALL","7 Years",{"count":73,"type":74},19,"ESTIMATED","INTERVENTIONAL",[14],"This study aims to determine the prevalence of shrimp sensitization and clinical shrimp allergy among patients aged ≥7 years with confirmed allergy to edible insects, including silkworm, bamboo worm, and palm weevil. Participants undergo skin prick testing, specific IgE testing, ALEX2, immunoblot analysis, and risk-based oral food challenges to assess clinical cross-reactivity between edible insects and white shrimp and to help avoid unnecessary shrimp restriction.",[79,80,81],"Edible Insect Allergy","Shrimp Allergy","Shrimp Sensitization",[83,84,85,86,87,88,89,90,91],"edible insect allergy","shrimp allergy","silkworm allergy","tropomyosin","crossreactivity","oral food challenge","skin prick test","edible insect","Alex","2026-10-05",{"date":94,"type":95},"2026-10-08","ACTUAL",{"date":97,"type":95},"2026-08-30",{"date":99,"type":74},"2027-06",{"name":5,"class":6},1]