[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652816":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":14,"collaborators":7,"id":18,"slug":19,"hasResults":20,"nctId":21,"briefTitle":22,"officialTitle":23,"acronym":7,"eligibilityCriteria":24,"healthyVolunteers":20,"sex":25,"minAge":26,"maxAge":27,"enrollmentInfo":28,"targetDuration":31,"studyType":32,"phases":7,"briefSummary":33,"conditions":34,"keywords":38,"overallStatus":42,"whyStopped":7,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":48,"leadSponsor":50,"locationsCount":7},{"fullName":5,"class":6},"Assiut University","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":12,"email":13},"Abobakr A bakr, Resident","CONTACT","01100440065","AbuBakr.18313431@med.aun.edu.eg",{"type":15,"investigatorFullName":16,"investigatorTitle":17,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Abobakr Ahmed Bakr Madkour","Resident","100652816","sii-and-siri-as-prognostic-biomarkers-in-lupus-nephritis-100652816",false,"NCT07780045","SII and SIRI as Prognostic Biomarkers in Lupus Nephritis","Emerging Inflammatory Biomarkers (SII and SIRI) for Predicting Disease Activity, Renal Flares and Outcomes in Lupus Nephritis: A Prospective Observational Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of systemic lupus erythematosus according to the 2019 EULAR\u002FACR classification criteria\n* Confirmed lupus nephritis according to ISN\u002FRPS classification\n\nExclusion Criteria:\n\n* Active infection, sepsis, or other concurrent inflammatory or autoimmune conditions\n* Malignancy or hematologic disorders affecting blood cell counts\n* Pregnancy\n* Use of medications significantly affecting blood counts (such as recent chemotherapy or G-CSF)\n* Incomplete medical records or anticipated loss to follow-up","ALL","18 Years","70 Years",{"count":29,"type":30},100,"ESTIMATED","12 Months","OBSERVATIONAL","This prospective observational study aims to evaluate the prognostic utility of the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) as novel inflammatory biomarkers for monitoring disease activity and predicting renal progression, flares, and outcomes in patients with lupus nephritis.",[35,36,37],"Lupus Nephritis","Systemic Lupus Erythematosus","Kidney Diseases",[39,40,41],"Systemic Immune-Inflammation Index SII","Systemic Inflammation Response Index SIRI","Lupus Nephritis Biomarkers","NOT_YET_RECRUITING","2026-08-19",{"date":45,"type":46},"2026-08-21","ACTUAL",{"date":43,"type":30},{"date":49,"type":30},"2027-10-19",{"name":5,"class":6}]