[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648766":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":18,"locations":29,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":69,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Nice","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Patients with peripheral sensory polyneuropathies",null,[12],"Other: Retrospective Medical Record Review",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":10},"Retrospective Medical Record Review","This observational study involves retrospective collection and analysis of routinely acquired clinical and electrophysiological data from approximately 180 patients with sensory polyneuropathy. Data extracted from medical records include demographic characteristics, clinical diagnosis, and nerve conduction study parameters, including sural and radial sensory nerve action potential amplitudes used to calculate the sural\u002Fradial amplitude ratio (SRAR). No additional diagnostic procedures, treatments, or study-specific assessments are performed. All data are obtained from standard clinical care.",[9],[19,25],{"name":20,"role":21,"phone":22,"phoneExt":23,"email":24},"Angela Puma","CONTACT","0492035435","+33","puma.ar@chu-nice.fr",{"name":26,"role":21,"phone":27,"phoneExt":23,"email":28},"Abderhmane Slioui","0492038953","slioui.a@chu-nice.fr",[30],{"facility":31,"status":10,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"CHU de Nice","Nice","Alpes Maritimes","06000","France","FR",{"type":38,"coordinates":39},"Point",[40,41],7.26608,43.70313,{"lat":41,"lon":40},[44,45],{"name":20,"role":21,"phone":22,"phoneExt":23,"email":24},{"name":46,"role":21,"phone":27,"phoneExt":23,"email":28},"Abderhmane de Nice",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100648766","single-center-study-evaluating-the-impact-of-age-on-the-diagnostic-performance-of-the-sural-to-radial-sensory-amplitude-ratio-in-length-dependent-and-non-length-dependent-peripheral-polyneuropathies-100648766",false,"NCT07725120","Single-Center Study Evaluating the Impact of Age on the Diagnostic Performance of the Sural-to-Radial Sensory Amplitude Ratio in Length-Dependent and Non-Length-Dependent Peripheral Polyneuropathies","Retrospective Single-Center Study Evaluating the Impact of Age on the Diagnostic Performance of the Sural-to-Radial Sensory Amplitude Ratio in Length-Dependent and Non-Length-Dependent Peripheral Polyneuropathies","ASPIRE","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Diagnosis of peripheral sensory polyneuropathy.\n* Classification as length-dependent (LDN) or non-length-dependent (NLDN) based on clinical and electrophysiological findings.\n* Available nerve conduction study including sural and radial sensory nerve amplitudes allowing calculation of the SRAR.\n* Evaluated at the Peripheral Neuromuscular Rare Disease Reference Center, Nice University Hospital, between January 2013 and July 2026.\n\nExclusion Criteria:\n\n* Missing or incomplete clinical or electrophysiological data preventing SRAR calculation.\n* Unclassifiable neuropathy phenotype.\n* Technical factors affecting the reliability of nerve conduction studies.","ALL","18 Years","90 Years",{"count":61,"type":62},180,"ESTIMATED","OBSERVATIONAL","This retrospective single-center observational study will evaluate the impact of age on the diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR) in patients with length-dependent and non-length-dependent peripheral sensory polyneuropathies. Clinical and electrophysiological data collected during routine care between January 2013 and July 2026 will be analyzed. Diagnostic performance will be assessed using receiver operating characteristic (ROC) curve analysis across predefined age groups to determine whether age-adjusted SRAR thresholds improve the differentiation between the two polyneuropathy phenotypes.",[66,67,68],"Polyneuropathies","Electromyography","Diagnostic Techniques","NOT_YET_RECRUITING","2026-07-21",{"date":72,"type":73},"2026-07-24","ACTUAL",{"date":75,"type":62},"2026-09-01",{"date":77,"type":62},"2026-12-31",{"name":5,"class":6},1]