[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100375572":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":10,"centralContacts":36,"locations":42,"responsibleParty":62,"collaborators":10,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":10,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":10,"enrollmentInfo":76,"targetDuration":10,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Rochester","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Atopic Dermatitis",null,"Intervention is whatever Rx the URMC dermatologist thinks is best suited to the subject as part of \"real-world\" disease management in her clinic.\n\n1\\. Ages: 1. 13-65 yrs of age (inclusive), all genders, races and ethnicities 2. Additional 66+ yrs of age group, all genders, races and ethnicities",[13],"Other: AD subject visit sampling procedures",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy control","No intervention\n\nAges:\n\n1. 13-65 yrs of age (inclusive), all genders, races and ethnicities\n2. Additional 66+ yrs of age group, all genders, races and ethnicities",[18],"Other: Healthy control visit sampling procedures",{"label":20,"type":10,"description":21,"interventionNames":22},"Psoriasis","Intervention is whatever Rx the URMC dermatologist thinks is best suited to the subject as part of \"real-world\" disease management in her clinic. Ages:13-65 yrs of age (inclusive), all genders, races and ethnicities.",[23],"Other: PS subject visit sampling procedures",[25,29,33],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"AD subject visit sampling procedures","Skin swabs for microbial analysis, Tape stripping and transepidermal water loss measurements (TEWL) with tape stripping (all patients) to assess skin barrier function, blood serum (adults \\& optional for adolescents), and optional biopsy (adults only)",[9],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"PS subject visit sampling procedures","Skin swabs for microbial analysis, Tape stripping and transepidermal water loss measurements (TEWL) with tape stripping (all patients) to assess skin barrier function, and blood serum (optional for all PS subjects)",[20],{"type":6,"name":34,"description":27,"armGroupLabels":35,"otherNames":10},"Healthy control visit sampling procedures",[15],[37],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Dermatology clinical trials unit","CONTACT","585-273-4195","DermCTU_Appointments@URMC.Rochester.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"University of Rochester Medical Center","RECRUITING","Rochester","New York","14642","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-77.61556,43.15478,{"lat":55,"lon":54},[58],{"name":59,"role":39,"phone":60,"phoneExt":10,"email":61},"Lisa Beck, MD","585-275-7546","lisa_beck@urmc.rochester.edu",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Lisa Beck","Professor","100375572","skin-microbial-ecology-in-atopic-dermatitis-100375572",false,"NCT04170244","Skin Microbial Ecology in Atopic Dermatitis","Longitudinal \"Real-World\" Changes in Skin Microbial Ecology in Atopic Dermatitis (AD) and Psoriasis (PS) Patients","Inclusion Criteria:\n\n* ≥13 to 65 years of age (inclusive) for PS, ≥13 for AD and NA, male or female\n* Optional Bx sub study - only adults (18-65 yrs; inclusive only)\n* Able to understand protocol and give consent\n* Able to keep clinic\u002Fstudy appointments and comply with study related procedures\n* Must be able to read, speak, and understand English\n* Chronic AD, according to the American Academy of Dermatology (AAD) Consensus Criteria (Eichenfield 2014), that has been present for at least 1 year before the enrollment visit\n* Chronic PS, according to the AAD Consensus Criteria (Menter et al 2008 (section 1)), that has been present for at least 1 year before the enrollment visit.\n* AD subjects: have active lesions on upper extremities, lower extremities, or trunk and a total disease severity of high moderate-to-severe (EASI ≥12)\n* PS subjects: have active lesions on upper extremities, lower extremities, or trunk and a total disease severity of high moderate-to-severe (PASI ≥7)\n\nExclusion Criteria:\n\n* Unwilling and\u002For unable to complete informed consent process\n* \\\u003C13 or \\> 65 years of age for PS, \\>13 for AD and NA\n* AD subjects: disease without upper extremity, lower extremity, or trunk lesions\n* AD subjects: total disease severity less than moderate (EASI \\\u003C12), depending on enrollment\n* PS subjects: disease without upper extremity, lower extremity, or trunk lesions\n* PS subjects: total disease severity less than moderate (PASI \\\u003C7), depending on enrollment\n* Control subjects: diagnosed with an inflammatory skin disease\n* Severe concomitant illness(es) that, in the investigator's judgment, would adversely affect the individual's participation in the study (Ex: HIV infection, autoimmune disease, severe heart failure, Hx of malignancy (other than in situ cervical cancer or basosquamous skin cancer), etc.)\n* Recent bacterial, fungal, or viral infection requiring systemic therapies (PO, IV or IM) within the last month.\n* Subjects with a history of serious life-threatening reaction to tape or adhesives may be enrolled but cannot undergo Tape stripping procedure and will therefore only have a baseline TEWL measurement.\n* (For Skin biopsy substudy only) - Subjects with history of keloid formation or allergy to lidocaine.",true,"ALL","13 Years",{"count":77,"type":78},240,"ESTIMATED","OBSERVATIONAL","Everybody's skin has bacteria that normally lives on it. Previous research has shown that people with eczema (or atopic dermatitis \\[AD\\]) have much higher concentrations of a certain bacteria (S. aureus), especially when their disease is active but little is known about the role that this bacteria plays in psoriasis (i.e. disease severity, biomarkers and skin barrier function). The overarching purpose of this longitudinal study is to understand how the abundance of skin S. aureus (and several commensal bacteria) change as a consequence of standard of care treatment in the URMC dermatology clinics. Other assays and biospecimens will also be collected to address a number of questions.",[9,20,82],"Healthy",[84],"staphylococcus, microbiome, atopic dermatitis, cutibacterium","2026-07-12",{"date":87,"type":88},"2026-07-14","ACTUAL",{"date":90,"type":88},"2019-04-17",{"date":92,"type":78},"2027-04-01",{"name":5,"class":6},1]