[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654616":3},{"organization":4,"outcomesModule":7,"designInfo":76,"detailedDescription":83,"studyPopulation":75,"armGroups":84,"interventions":91,"overallOfficials":97,"centralContacts":105,"locations":113,"responsibleParty":126,"collaborators":75,"id":130,"slug":131,"hasResults":132,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":75,"eligibilityCriteria":136,"healthyVolunteers":132,"sex":137,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":75,"studyType":143,"phases":144,"briefSummary":145,"conditions":146,"keywords":154,"overallStatus":159,"whyStopped":75,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":169},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":75},[9],{"measure":10,"description":11,"timeFrame":12},"Mean nocturnal SpO2 after 7 days at sea level","Difference in mean nocturnal SpO2 between 2850m and Night 7 at sea level in patients with pulmonary arterial hypertension","From high altitude (2850m) to night 7 at sea level",[14,17,20,23,26,30,33,36,39,42,46,50,53,56,59,63,66,69,72],{"measure":15,"description":16,"timeFrame":12},"Time spent with low SpO2 after 7 days at sea level","Difference\u002Fchange in time spent with low SpO2 (\\\u003C 90% and \\\u003C 80%) between 2850m and night 7 at sea level in patients with pulmonary arterial hypertension",{"measure":18,"description":19,"timeFrame":12},"Apnoea-Hypopnoea-Index AHI after 7 days at sea level","Difference\u002Fchange in nocturnal apnoea-hypopnoea-index between 2850m and night 7 at sea level in patients with pulmonary arterial hypertension",{"measure":21,"description":22,"timeFrame":12},"Oxygen-Desaturation-Index ODI after 7 days at sea level","Difference\u002Fchange in nocturnal Oxygen-Desaturation-Index ODI between 2850m and night 7 at sea level in patients with pulmonary arterial hypertension",{"measure":24,"description":25,"timeFrame":12},"Nocturnal cardiovascular autonomic control after 7 days at sea level","Difference\u002Fchange in nocturnal cardiovascular autonomic control by heart rate (variability) between 2850m and night 7 at sea level in patients with pulmonary arterial hypertension",{"measure":27,"description":28,"timeFrame":29},"Acclimatization-Effect of mean nocturnal SpO2 at sea level","Difference\u002Fchange in mean nocturnal SpO2 at night 1 and night 7 within a stay at sea level of 7 days (after relocation from high altitude) in patients with pulmonary arterial hypertension","From Night 1 to Night 7 at sea level",{"measure":31,"description":32,"timeFrame":29},"Acclimatization-Effect of time spent with low SpO2 at sea level","Difference\u002Fchange in time spent with low SpO2 (\\\u003C 90% and \\\u003C 80%) at night 1 and night 7 within a stay at sea level of 7 days (after relocation from high altitude) in patients with pulmonary arterial hypertension",{"measure":34,"description":35,"timeFrame":29},"Acclimatization-Effect of Apnoea-Hypopnoea-Index AHI at sea level","Difference\u002Fchange in nocturnal apnoea-hypopnoea-index at night 1 and night 7 within a stay at sea level of 7 days (after relocation from high altitude) in patients with pulmonary arterial hypertension",{"measure":37,"description":38,"timeFrame":29},"Acclimatization-Effect of Oxygen-Desaturation-Index ODI at sea level","Difference\u002Fchange in nocturnal oxygen-desaturation-index ODI at night 1 and night 7 within a stay at sea level of 7 days (after relocation from high altitude) in patients with pulmonary arterial hypertension",{"measure":40,"description":41,"timeFrame":29},"Acclimatization-Effect of nocturnal cardiovascular autonomic control at sea level","Difference\u002Fchange in nocturnal cardiovascular autonomic control by heart rate (variability) at night 1 and night 7 within a stay at sea level of 7 days (after relocation from high altitude) in patients with pulmonary arterial hypertension",{"measure":43,"description":44,"timeFrame":45},"Mean nocturnal SpO2 after re-ascent to 2850m","Difference\u002Fchange in mean nocturnal SpO2 between sea level (after one-week stay) and night after re-ascent to 2850m in patients with pulmonary arterial hypertension","From Night 7 at sea level to night after reascent (time frame of 3 days)",{"measure":47,"description":48,"timeFrame":49},"Time spent with low SpO2 after re-ascent to 2850m","Difference\u002Fchange in time spent with low SpO2 (\\\u003C 90% and \\\u003C 80%) between sea level (after one-week stay) and night after re-ascent to 2850m in patients with pulmonary arterial hypertension","From Night 7 at sea level to night after re-ascent (time frame of 3 days)",{"measure":51,"description":52,"timeFrame":49},"Apnoea-Hypopnoea-Index AHI after re-ascent to 2850m","Difference\u002Fchange in nocturnal apnoea-hypopnoea-index between sea level (after one-week stay) and night after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":54,"description":55,"timeFrame":49},"Oxygen-Desaturation-Index ODI after re-ascent to 2850m","Difference\u002Fchange in nocturnal oxygen-desaturation-index between sea level (after one-week stay) and night after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":57,"description":58,"timeFrame":49},"Nocturnal cardiovascular autonomic control after re-ascent to 2850m","Difference\u002Fchange in nocturnal cardiovascular autonomic control by heart rate (variability) between sea level (after one-week stay) and night after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":60,"description":61,"timeFrame":62},"Mean nocturnal SpO2 pre-descent and after re-ascent (2850m)","Difference\u002Fchange in mean nocturnal SpO2 between the night at 2850m prior to the descent to sea level (stay of 7 days at sea level in between) and the night at 2850m after re-ascent in patients with pulmonary arterial hypertension","From the night at 2850m prior to the descent, stay at sea level of one week in between to the night after re-ascent to 2850m (time frame approximately 11 days)",{"measure":64,"description":65,"timeFrame":62},"Time spent with low SpO2 pre-descent and after re-ascent (2850m)","Difference\u002Fchange in time spent with low SpO2 (\\\u003C 90% and \\\u003C 80%) between the night at 2850m prior to the descent to sea level (stay of 7 days at sea level in between) and the night at 2850m after re-ascent in patients with pulmonary arterial hypertension",{"measure":67,"description":68,"timeFrame":62},"Apnoea-Hypopnoea-Index AHI pre-descent and after re-ascent (2850m)","Difference\u002Fchange in nocturnal apnoea-hypopnoea-index between the night at 2850m prior to the descent to sea level (stay of 7 days at sea level in between) and the night at 2850m after re-ascent in patients with pulmonary arterial hypertension",{"measure":70,"description":71,"timeFrame":62},"Oxygen-Desaturation-Index ODI pre-descent and after re-ascent (2850m)","Difference\u002Fchange in nocturnal oxygen-desaturation-index between the night at 2850m prior to the descent to sea level (stay of 7 days at sea level in between) and the night at 2850m after re-ascent in patients with pulmonary arterial hypertension",{"measure":73,"description":74,"timeFrame":62},"Nocturnal cardiovascular autonomic control pre-descent and after re-ascent (2850m)","Difference\u002Fchange in nocturnal cardiovascular autonomic control by heart rate (variability) between the night at 2850 prior to the descent to sea level (stay of 7 days at sea level in between) and the night at 2850m after re-ascent in patients with pulmonary arterial hypertension",null,{"allocation":77,"interventionModel":78,"interventionModelDescription":79,"primaryPurpose":80,"observationalModel":75,"timePerspective":75,"maskingInfo":81},"NA","SINGLE_GROUP","Patients with pulmonary arterial hypertension living permanently \\> 2600m around Quito (Ecuador) will be assessed at 2850m, after relocation to sea level for 7 days and after re-ascent","SUPPORTIVE_CARE",{"masking":82,"maskingDescription":75,"whoMasked":75},"NONE","The aim of this research is to investigate sleeping parameters by polygraphy before and after relocation (high altitude near their living altitude vs. sea level) in patients with diagnosed pulmonary arterial hypertension according to guidelines, who permanently live at high altitude over 2600m",[85],{"label":86,"type":87,"description":88,"interventionNames":89},"Sleep-parameters at 2850m and at sea level","EXPERIMENTAL","Assessment of sleep-parameters by polygraphy in patients with pulmonary arterial hypertension at 2850m and at sea level",[90],"Behavioral: Descent to sea level",[92],{"type":93,"name":94,"description":95,"armGroupLabels":96,"otherNames":75},"BEHAVIORAL","Descent to sea level","Descent from 2850m to sea level with a stay for 7 days and re-ascent back to 2850m",[86],[98,102],{"name":99,"affiliation":100,"role":101},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":103,"affiliation":104,"role":101},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[106,111],{"name":107,"role":108,"phone":109,"phoneExt":75,"email":110},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":112,"role":108,"phone":109,"phoneExt":75,"email":75},"Michael Furian, Prof. Dr. sc. ETH",[114],{"facility":115,"status":75,"city":116,"state":75,"zip":117,"country":118,"countryCode":119,"cosmosGeoPoint":120,"geoPoint":125,"contacts":75},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":121,"coordinates":122},"Point",[123,124],8.55,47.36667,{"lat":124,"lon":123},{"type":127,"investigatorFullName":128,"investigatorTitle":129,"investigatorAffiliation":5,"oldNameTitle":75,"oldOrganization":75},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654616","sleep-assessment-in-patients-between-high-altitude-ha-vs-sea-level-la-in-patients-with-pulmonary-arterial-hypertension-pah-100654616",false,"NCT07801963","Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adult patients aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* Diagnosis of pulmonary arterial hypertension PAH (PAHHA-Group) according to guidelines\n* Patients are stable on therapy\n* NYHA (new york heart association) functional class I-III.\n* written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* unstable condition\n* Patients who cannot follow the study investigations\n* Patient permanently living \\\u003C 2600m.\n* Patients who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks.\n* Patients with moderate to severe concomitant lung disease (FEV1\\\u003C70% or forced vital capacity \\\u003C70%), severe parenchymal lung disease, severe smokers (\\>20 cigarettes\u002Fday)\n* Severely hypoxemic patients at Quito permanently having persistent SpO2 (oxygen saturation by pulseoximetry) \\\u003C80% on ambient air.\n* Patient with a non-corrected ventricular septum defect\n* Relevant concomitant other disease of the heart, kidney, liver, blood (anemia hemoglobin\\\u003C11 g\u002Fdl)","ALL","18 Years","80 Years",{"count":141,"type":142},20,"ESTIMATED","INTERVENTIONAL",[77],"To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in patients with pulmonary arterial hypertension PAH, who live permanently \\>2600m.",[147,148,149,150,151,152,153],"Pulmonary Arterial Hypertension (PAH)","Pulmonary Vascular Disease","Polygraphy","Sleep","Sleep Disordered Breathing (SDB)","High Altitude Effects","High Altitude",[147,155,153,156,149,150,157,158],"Hypoxia","Pulmonary Hypertension","Sleep disordered breathing SDB","Pulmonary vascular disease","NOT_YET_RECRUITING","2026-08-31",{"date":162,"type":163},"2026-09-03","ACTUAL",{"date":165,"type":142},"2026-09-25",{"date":167,"type":142},"2026-12-31",{"name":128,"class":6},1]