[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648116":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":37,"locations":29,"responsibleParty":47,"collaborators":29,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":29,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":82,"whyStopped":29,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":29},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Combined Intervention","EXPERIMENTAL","Participants will receive smartphone-guided paced breathing combined with supervised moderate-intensity aerobic exercise three sessions per week for 12 weeks, in addition to their usual antihypertensive medication.",[13],"Behavioral: Smartphone-Guided Paced Breathing + Aerobic Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Aerobic Exercise","Participants will receive supervised moderate-intensity aerobic exercise three sessions per week for 12 weeks, in addition to their usual antihypertensive medication.",[18],"Behavioral: Aerobic Exercise",{"label":20,"type":10,"description":21,"interventionNames":22},"Smartphone-Guided Paced Breathing","Participants will receive smartphone-guided paced breathing training for 12 weeks, in addition to their usual antihypertensive medication.",[23],"Behavioral: Smartphone-Guided Paced Breathing",[25,30,33],{"type":26,"name":20,"description":27,"armGroupLabels":28,"otherNames":29},"BEHAVIORAL","Participants will perform smartphone-guided paced breathing at approximately 6 breaths per minute according to the study protocol for 12 weeks in addition to usual medical care.",[20],null,{"type":26,"name":15,"description":31,"armGroupLabels":32,"otherNames":29},"Participants will perform supervised moderate-intensity aerobic exercise three sessions per week for 12 weeks in addition to usual medical care.",[15],{"type":26,"name":34,"description":35,"armGroupLabels":36,"otherNames":29},"Smartphone-Guided Paced Breathing + Aerobic Exercise","Participants will receive smartphone-guided paced breathing combined with supervised moderate-intensity aerobic exercise for 12 weeks in addition to usual medical care.",[9],[38,43],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},"Shimaa Taha, PhD","CONTACT","+201021088610","shimaa.taha@cu.edu.eg",{"name":44,"role":40,"phone":45,"phoneExt":29,"email":46},"Mona Ziethar, Lecturer of Physical Therapy f","+201151602624","monaamin028@gmail.com",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Shimaa Taha Mohamed Taha","Lecturer of Cardiovascular &Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University","100648116","smartphone-guided-paced-breathing-and-aerobic-exercise-for-essential-hypertension-100648116",false,"NCT07717996","Smartphone-Guided Paced Breathing and Aerobic Exercise for Essential Hypertension","Effect of Smartphone-Guided Paced Breathing Combined With Aerobic Exercise on Blood Pressure, Functional Capacity, and Quality of Life in Patients With Essential Hypertension","SPB-HTN","Inclusion Criteria:\n\nAdults aged 40-50 years. Both males and females. Clinically diagnosed with essential (primary) hypertension confirmed by a physician.\n\nStage 1-2 hypertension (SBP 130-160 mmHg and\u002For DBP 80-100 mmHg) based on standardized clinical measurement.\n\nDuration of diagnosed hypertension between 6 months and 5 years. Stable on antihypertensive medication for at least 4 weeks prior to enrollment, with no planned medication changes.\n\nMedically stable and cleared for participation in moderate-intensity exercise. Able to understand instructions and independently perform smartphone-guided breathing exercises.\n\nWilling to participate and provide written informed consent.\n\nExclusion Criteria:\n\nSecondary hypertension (e.g., renal, endocrine, or medication-induced hypertension).\n\nSevere or uncontrolled hypertension (SBP \\>180 mmHg and\u002For DBP \\>110 mmHg). History of major cardiovascular events (e.g., myocardial infarction within the past 6 months, unstable angina, uncontrolled arrhythmias, or decompensated heart failure).\n\nChronic respiratory diseases affecting exercise tolerance (e.g., chronic obstructive pulmonary disease \\[COPD\\] or severe asthma).\n\nNeurological, musculoskeletal, or orthopedic conditions that limit safe participation in walking or exercise training.\n\nCognitive impairment or psychiatric disorders that affect comprehension or adherence to the study protocol.\n\nParticipation in a structured exercise or pulmonary rehabilitation program within the previous 3 months.\n\nHeavy smoking. Pregnancy or lactation. Contraindications to exercise testing or training according to the American College of Sports Medicine (ACSM) guidelines.\n\nAnticipated changes in antihypertensive medication during the study period.","ALL","40 Years","50 Years",{"count":63,"type":64},75,"ESTIMATED","INTERVENTIONAL",[67],"NA","Hypertension is a major risk factor for cardiovascular disease and is associated with reduced functional capacity and impaired quality of life. Non-pharmacological interventions, including aerobic exercise and paced breathing, may improve blood pressure control by enhancing cardiovascular and autonomic function. This randomized controlled trial will evaluate whether combining smartphone-guided paced breathing with aerobic exercise provides greater benefits than either intervention alone in adults with essential hypertension. Seventy-five participants will be randomly assigned to one of three groups: (1) smartphone-guided paced breathing combined with aerobic exercise, (2) aerobic exercise alone, or (3) smartphone-guided paced breathing alone. The intervention will last 12 weeks. The primary outcome measures are systolic and diastolic blood pressure. Secondary outcome measures include heart rate, functional capacity assessed by the 6-Minute Walk Test, and health-related quality of life assessed using the Short Form-12 (SF-12) questionnaire. The findings of this study may help identify an effective, accessible, and low-cost non-pharmacological strategy for improving cardiovascular health and quality of life in patients with essential hypertension.",[70],"Essential (Primary) Hypertension",[72,15,20,73,74,75,76,77,78,79,80,81],"Essential Hypertension","Physical Therapy","Blood Pressure","Functional Capacity","Six-Minute Walk Test","Quality of Life","SF-12","Mobile Health","Nonpharmacological Treatment","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-07-21",{"date":85,"type":86},"2026-07-22","ACTUAL",{"date":88,"type":64},"2026-07-25",{"date":90,"type":64},"2026-12-01",{"name":5,"class":6}]