[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649013":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":32,"responsibleParty":60,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":10,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":83,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Istanbul University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Adults Undergoing Biopsy for Suspected Primary or Metastatic Bone or Soft Tissue Malignancy",null,"Single prospective cohort of adults undergoing clinically indicated biopsy for a suspected solid tumor involving bone or soft tissue. Participants are assessed before biopsy, after pathology-result disclosure, and at treatment initiation. No diagnostic or therapeutic intervention is assigned by the study.",[13],"Other: Routine Diagnostic and Treatment Pathway",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Routine Diagnostic and Treatment Pathway","Observational exposure of interest. Participants undergo clinically indicated biopsy, pathology-result disclosure, and treatment initiation according to routine clinical care. The study does not assign biopsy, imaging, surgery, systemic treatment, radiotherapy, or any other treatment. Research activities consist of psychological questionnaires and collection of routine demographic, clinical, and radiologic data at the prespecified assessment points.",[9],[20],{"name":21,"affiliation":5,"role":22},"Serkan Bayram, M.D.","PRINCIPAL_INVESTIGATOR",[24,28],{"name":21,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+90 535 384 1408","dr.serkanbayram89@gmail.com",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Irmak Polat, M.D.","+90 543 773 1949","irmak.polat@istanbul.edu.tr",[33],{"facility":34,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":10,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Istanbul University, Istanbul Faculty of Medicine, Department of Orthopedics and Traumatology","RECRUITING","Istanbul","34093","Turkey (Türkiye)",{"type":40,"coordinates":41},"Point",[42,43],28.94966,41.01384,{"lat":43,"lon":42},[46,47,51,52,54,56,58],{"name":21,"role":25,"phone":26,"phoneExt":10,"email":27},{"name":48,"role":25,"phone":49,"phoneExt":10,"email":50},"İsmail Tarık Atasoy, M.D.","+90 534 632 0870","tarikatasoy96@gmail.com",{"name":21,"role":22,"phone":10,"phoneExt":10,"email":10},{"name":29,"role":53,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":55,"role":53,"phone":10,"phoneExt":10,"email":10},"İsmail T. Atasoy, M.D.",{"name":57,"role":53,"phone":10,"phoneExt":10,"email":10},"Zeynep E. Çalış, M.D.",{"name":59,"role":53,"phone":10,"phoneExt":10,"email":10},"Hilal Aydemir, M.D.",{"type":22,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Serkan Bayram, MD","Associate Professor of Orthopedics and Traumatology","100649013","stress-and-anxiety-before-biopsy-after-biopsy-results-and-during-treatment-in-patients-with-suspected-bone-or-soft-tissue-cancer-100649013",false,"NCT07727434","Stress and Anxiety Before Biopsy, After Biopsy Results, and During Treatment in Patients With Suspected Bone or Soft Tissue Cancer","Comparative Evaluation of Psychological Stress and Anxiety Levels Before Biopsy, After Diagnosis, and During Treatment in Patients With Suspected Primary or Metastatic Bone or Soft Tissue Malignancy","BIOPSY-STRESS","Inclusion Criteria:\n\n* Age 18 years or older.\n* Scheduled for biopsy because of a suspected solid tumor.\n* Able to understand and answer the study questionnaires.\n* Able and willing to provide written informed consent before study participation.\n\nExclusion Criteria:\n\n* History of previous malignancy.\n* Current serious psychiatric disorder, including major depressive disorder or psychotic disorder.\n* Cognitive impairment or communication difficulty that prevents valid completion of the study questionnaires.\n* Severe general medical condition or need for emergency intervention that makes study participation inappropriate.","ALL","18 Years",{"count":74,"type":75},100,"ESTIMATED","OBSERVATIONAL","This prospective observational study will follow adults who are scheduled for a clinically indicated biopsy because of a suspected solid tumor involving bone or soft tissue. The period before biopsy, the disclosure of pathology results, and the start of treatment may be associated with changing levels of psychological stress and anxiety.\n\nThe purpose of the study is to compare psychological stress and anxiety in the same participants at three points in their care: before biopsy, after the pathology result or diagnosis is explained, and at treatment initiation. The investigators hypothesize that psychological questionnaire scores will differ across these three time points and may be associated with age, sex, disease stage, metastasis status, and treatment type.\n\nParticipants will complete the Hospital Anxiety and Depression Scale, Perceived Stress Scale, and Distress Thermometer. The study team will also collect relevant demographic and routine clinical information from medical records. The study will not assign any biopsy, diagnostic procedure, or treatment. All diagnostic and treatment decisions will be made by the treating clinical team as part of routine care.",[79,80,81,82],"Bone Neoplasms","Soft Tissue Neoplasms","Anxiety","Stress, Psychological",[84,85,86,87,88,89,90,91,92,81,93,94,95,96],"Orthopedic oncology","Biopsy","Solid tumor","Bone tumor","Soft tissue tumor","Cancer diagnosis","Pathology result disclosure","Treatment initiation","Psychological distress","Depression","Hospital Anxiety and Depression Scale","Perceived Stress Scale","Distress Thermometer","2026-07-24",{"date":99,"type":100},"2026-07-27","ACTUAL",{"date":102,"type":100},"2026-07-20",{"date":104,"type":75},"2027-01-20",{"name":5,"class":6},1]