[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651064":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":37,"responsibleParty":68,"collaborators":72,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":24,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":39,"whyStopped":24,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Southern California","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: Fluid Resuscitation in Stroke Volume with Leg Raise","EXPERIMENTAL","We suggest that changes in stroke volume on individual patients can further improve outcomes with fluid resuscitation and prevent fluid overload in the individuals with acute pancreatitis.",[13],"Other: Lactated Ringers Stroke Volume Based Dosing",{"label":15,"type":6,"description":16,"interventionNames":17},"Group 2: Moderate fluid resuscitation per body weight","This arm is based on a past fluid resuscitation study, WATERFALL Study, where there was moderate fluid resuscitation in the setting of treatment for acute pancreatitis.",[18],"Other: Lactated Ringer's",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Lactated Ringer's","lactated ringer's in intervention is dosed based on changes in stroke volume versus a weight based strategy",[15],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Lactated Ringers Stroke Volume Based Dosing","Lactated Ringers Rate is based on changes in stroke volume",[9],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"James L Buxbaum, MD","CONTACT","323 442 0876","jorge.zunigagomez@med.usc.edu",{"name":36,"role":32,"phone":33,"phoneExt":24,"email":34},"Jorge Zuniga-Gomez, BS",[38,57],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Los Angeles","California","90033","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-118.24368,34.05223,{"lat":49,"lon":48},[52,55],{"name":53,"role":32,"phone":54,"phoneExt":24,"email":34},"Jorge Zuniga, BS","3234420876",{"name":56,"role":32,"phone":54,"phoneExt":24,"email":34},"Jorge ZunigaGomez, BS",{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":43,"countryCode":44,"cosmosGeoPoint":63,"geoPoint":67,"contacts":24},"Ohio State University","ACTIVE_NOT_RECRUITING","Columbus","Ohio","43210",{"type":46,"coordinates":64},[65,66],-82.99879,39.96118,{"lat":66,"lon":65},{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","James Buxbaum","Principal Investigator, Clinical Scholar, MD",[73],{"name":58,"class":6},"100651064","stroke-volume-based-fluid-resuscitation-in-ap-100651064",false,"NCT07756476","Stroke Volume-based Fluid Resuscitation in AP","Stroke volUme-baSed Fluid resusciTAtIoN in AP (SUSTAIN)","SUSTAIN","Inclusion Criteria:\n\n* Patients between the age of 18-75\n* Predicted moderate and severe acute pancreatitis, which will be defined by the presence of SIRs, within 24 hours of enrollment\n\nExclusion Criteria:\n\n* Patients with the inability to preform a straight leg raise (i.e amputation)\n* Patients with high risk of adverse event related to fluid resuscitation\n* NYHA Class \\>= II Heart Failure\n* Child's B and C Cirrhosis\n* Dialysis Requirement\n* Clinical signs of hypervolemia, including pulmonary congestion (i.e dyspnea, pulmonary crackles on exam, interstitual edema on imaging) and ascites\n* Ages \\\u003C18 years old\n* Pregnant\n* Incarcerated\n* Unable to provide informed consent","ALL","18 Years","75 Years",{"count":86,"type":87},80,"ESTIMATED","INTERVENTIONAL",[90],"NA","The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.",[93],"Acute Pancreatitis (AP)",[95,96,97,98],"Acute Pancreatitis","Fluid Resuscitation","Pancreatitis","Stroke Volume","2026-08-05",{"date":101,"type":102},"2026-08-10","ACTUAL",{"date":104,"type":102},"2026-03-19",{"date":106,"type":87},"2028-09-19",{"name":5,"class":6},2]