[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592451":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":47,"centralContacts":51,"locations":56,"responsibleParty":77,"collaborators":79,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":10,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":92,"maxAge":10,"enrollmentInfo":93,"targetDuration":10,"studyType":96,"phases":10,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Maryland, Baltimore","OTHER",[8,16,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Normal Tension Glaucoma",null,"Newly diagnosed, treatment-naïve subjects with normal tension glaucoma. Brillouin imaging will be performed at baseline, and in a subset receiving IOP-lowering therapy, additional imaging will be performed at 3 and 6 weeks.",[13,14,15],"Drug: Prostaglandin Analogue -Containing IOP-Lowering Therapy","Drug: Beta Blocker","Device: Brillouin Microscopy",{"label":17,"type":10,"description":18,"interventionNames":19},"High Tension Glaucoma","Newly diagnosed, treatment-naïve subjects with high tension glaucoma. Brillouin imaging will be performed at baseline, and in a subset receiving IOP-lowering therapy, additional imaging will be performed at 3 and 6 weeks.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Control","Age-matched healthy control subjects with no history of glaucoma or IOP-lowering therapy. Brillouin imaging will be performed at a single time point for cross-sectional comparison.",[15],[25,34,40],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Prostaglandin Analogue -Containing IOP-Lowering Therapy","Subjects with glaucoma may be prescribed prostaglandin analogs as part of their clinical care. This group will be observed longitudinally to assess changes in corneal biomechanics.",[17,9],[31,32,33],"Latanoprost","Travaprost","Bimatoprost",{"type":26,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Beta Blocker","Subjects with glaucoma may be prescribed topical beta blockers as part of their clinical care. This group will be observed longitudinally to assess changes in corneal biomechanics.",[17,9],[39],"Timolol",{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"DEVICE","Brillouin Microscopy","Brillouin microscopy is a non-contact optical imaging method used to assess the biomechanical properties of the cornea in vivo with three-dimensional resolution. It will be used to evaluate corneal stiffness in all study subjects.",[21,17,9],[46],"Brillouin Imaging",[48],{"name":49,"affiliation":5,"role":50},"Osamah Saeedi, MD","PRINCIPAL_INVESTIGATOR",[52],{"name":49,"role":53,"phone":54,"phoneExt":10,"email":55},"CONTACT","16672141232","osaeedi@som.umaryland.edu",[57],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"University of Maryland School of Medicine","RECRUITING","Baltimore","Maryland","21201-1757","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-76.61219,39.29038,{"lat":69,"lon":68},[72,75,76],{"name":49,"role":53,"phone":73,"phoneExt":10,"email":74},"667-214-1232","eyeresearch@som.umaryland.edu",{"name":10,"role":53,"phone":10,"phoneExt":10,"email":55},{"name":49,"role":50,"phone":10,"phoneExt":10,"email":10},{"type":78,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[80],{"name":81,"class":82},"National Eye Institute (NEI)","NIH","100592451","study-of-corneal-biomechanics-in-glaucoma-patients-using-brillouin-microscopy-100592451",false,"NCT06993597","Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy","Development of Robust Corneal Biomechanical Biomarkers for Glaucoma Using Brillouin Microscopy","Inclusion Criteria:\n\n\\- Age 18 years or older\n\nDiagnosis of primary open angle glaucoma (POAG) or no history of glaucoma (for controls)\n\nOpen angle on gonioscopy (Shaffer grade 3 or 4)\n\nBest-corrected visual acuity of 20\u002F25 or better\n\nRefractive error between +3.00 and -5.00 diopters\n\nNo prior use of topical glaucoma medications\n\nDiagnosis of:\n\nHigh Tension Glaucoma (IOP ≥ 22 mmHg on 3 visits)\n\nNormal Tension Glaucoma (IOP ≤ 21 mmHg on 3 visits)\n\nOR age-matched control with normal optic nerve and visual fields\n\nExclusion Criteria:\n\nCorneal abnormalities or conditions interfering with Brillouin or applanation tonometry\n\nRetinal diseases affecting RNFL (e.g., macular traction)\n\nHistory of ocular surgery or laser\n\nDiagnosis of diabetes\n\nHistory of uveitis\n\nHistory of prolonged steroid use\n\nNeurodegenerative or systemic diseases (e.g., multiple sclerosis, Alzheimer's, Parkinson's, schizophrenia)\n\nUnreliable visual fields\n\nContraindications to beta blockers (e.g., bradycardia, severe pulmonary disease)\n\nModerate to severe glaucoma (per Hodapp-Anderson-Parrish criteria)\n\nHistory of contact lens use\n\nLow blood pressure",true,"ALL","18 Years",{"count":94,"type":95},60,"ESTIMATED","OBSERVATIONAL","This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness between patients with normal-tension glaucoma, high-tension glaucoma, and healthy controls, and to assess changes in corneal biomechanics following intraocular pressure (IOP)-lowering treatment. The goal is to determine whether Brillouin-derived biomechanical measurements can serve as biomarkers for glaucoma risk and progression.",[99],"Glaucoma",[101,102,103],"glaucoma","cornea","biomechanics","2026-08-07",{"date":106,"type":107},"2026-08-10","ACTUAL",{"date":109,"type":107},"2025-09-01",{"date":111,"type":95},"2027-06",{"name":5,"class":6},1]