[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658482":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":32,"studyPopulation":33,"armGroups":29,"interventions":29,"overallOfficials":34,"centralContacts":39,"locations":44,"responsibleParty":58,"collaborators":29,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":29,"studyType":75,"phases":29,"briefSummary":76,"conditions":77,"keywords":29,"overallStatus":47,"whyStopped":29,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Centre Hospitalier St Anne","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":20,"otherOutcomes":29},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"Working memory performance - Cogmed","Cognitive trajectories will be characterized using performance measures derived from the home-based training.","5 week.",{"measure":14,"description":15,"timeFrame":16},"Working memory performance - CANTAB","Cognitive trajectories will be characterized using performance measures derived from the Spatial Span (SSP) task from the CANTAB battery, administered under standardized conditions at GHU Paris Psychiatry and Neurosciences.","2 week",{"measure":18,"description":19,"timeFrame":16},"Multimodal MRI data","Multimodal MRI data - including anatomical, resting-state, working memory (WM) task-based functional, and diffusion-weighted sequences - will be acquired repeatedly over a six-week period during WM training, as well as before and after the training phase.",[21,25],{"measure":22,"description":23,"timeFrame":24},"executive functions performance","To enable complementary analyses of non-trained executive functions (EF), the participant will complete three tasks from the NIH Toolbox Cognitive Battery.","1 week",{"measure":26,"description":27,"timeFrame":28},"behavioral variables","At baseline, we will collect demographic and cognitive information including age, sex, years of education, and baseline cognitive performance. In addition, we will record a set of covariates related to the participant's state during the scanning session and within the 24 hours preceding each training session.","5 week for most variables",null,{"allocation":29,"interventionModel":29,"interventionModelDescription":29,"primaryPurpose":29,"observationalModel":31,"timePerspective":6,"maskingInfo":29},"CASE_ONLY","The participants will benefit from a comprehensive training program in the Memory of the taught by the computerized CogMed method. This training showed a positive effect for improve the skills in Memory of the working in the healthy subject","healthy adult volunteers aged 18 to 30 who have no contraindications to an MRI scan.",[35],{"name":36,"affiliation":37,"role":38},"CACHIA Arnaud","hospital saint anne of the GHU Paris","PRINCIPAL_INVESTIGATOR",[40],{"name":36,"role":41,"phone":42,"phoneExt":29,"email":43},"CONTACT","0661519200","arnaud.cachia@u-paris.fr",[45],{"facility":46,"status":47,"city":48,"state":29,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":29},"CACHIA","RECRUITING","Paris","75014","France","FR",{"type":53,"coordinates":54},"Point",[55,56],2.3488,48.85341,{"lat":56,"lon":55},{"type":59,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100658482","study-of-individual-neurocognitive-changes-associated-with-the-training-of-the-working-memory-100658482",false,"NCT07851051","Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory.","Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory(SAMPLEX)","SAMPLEX","Inclusion Criteria:\n\nThe inclusion criteria include\n\n* age between 18 and 30 years,\n* right-handedness (assessed using the Edinburgh Handedness Inventory),\n* native French speaker, affiliation with the French national health insurance system\n* provision of written informed consent prior to participation.\n\nExclusion Criteria:\n\nExclusion criteria include:\n\n* contraindications to MRI,\n* neurological or psychiatric disorders\n* history of traumatic brain injury\n* any geographical or psychological condition preventing full compliance with the study protocol.",true,"ALL","18 Years","30 Years",{"count":73,"type":74},8,"ESTIMATED","OBSERVATIONAL","8 participants including 2 pilots. The 2 pilot participants will each execute an MRI acquisition session in order to adjust the experimental paradigm",[78],"Mental Health","2026-09-24",{"date":81,"type":82},"2026-10-01","ACTUAL",{"date":84,"type":82},"2025-09-29",{"date":86,"type":74},"2030-09-29",{"name":5,"class":6},1]