[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100110076":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":22,"locations":32,"responsibleParty":49,"collaborators":52,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":10,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Baylor College of Medicine","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental",null,"Individuals with Aicardi syndrome and their first-degree relatives",[13],"Other: Syndrome cause identification",[15],{"type":6,"name":16,"description":10,"armGroupLabels":17,"otherNames":10},"Syndrome cause identification",[9],[19],{"name":20,"affiliation":5,"role":21},"Ignatia B Van den Veyver, MD","PRINCIPAL_INVESTIGATOR",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Ignatia Van den Veyver, PMD","CONTACT","832-824-8125","iveyver@bcm.edu",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Imen Chakchouk, PhD","832-824-8156","imen.chakchouk@bcm.edu",[33],{"facility":5,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Houston","Texas","77030","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-95.36327,29.76328,{"lat":44,"lon":43},[47,48],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},{"name":20,"role":21,"phone":10,"phoneExt":10,"email":10},{"type":21,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ignatia Van den Veyver","Professor",[53],{"name":54,"class":6},"Aicardi Syndrome Foundation","100110076","study-of-selected-x-linked-disorders-aicardi-syndrome-100110076",false,"NCT00697411","Study of Selected X-Linked Disorders: Aicardi Syndrome","Pathogenesis of Selected X-Linked Dominant Disorders and New Strategies to Identify the Gene Mutated in Aicardi Syndrome","Inclusion Criteria:\n\n* Features suggestive of Aicardi syndrome (not all features must be present)\n\n  * Agenesis of the corpus callosum\n  * Chorioretinal lacunae\n  * Seizures (infantile spasms)\n\nExclusion Criteria:\n\n* none","ALL",{"count":64,"type":65},500,"ESTIMATED","OBSERVATIONAL","Based on our current understanding of Aicardi syndrome, the condition is hypothesized to occur due to a genetic change on the X-chromosome. The research team is investigating Aicardi syndrome to identify the specific gene location associated with the disorder. The investigators are collecting blood and skin biopsy samples from patients and their parents. A permanent cell line is prepared and DNA from the blood and skin samples and cell lines is isolated and then used for genetic testing. The current research includes microarray analysis which which is used to look for duplications or deletions of genetic material, mutation analysis of candidate genes by sequencing, genome-wide sequencing, review of medical records to identify trends suggesting possible candidate genes of interest, and X chromosome inactivation studies.",[69,70],"Aicardi Syndrome","Brain Disorders",[72,73,74],"Aicardi syndrome","Neurodevelopmental disorders","X-linked disorders","2026-04-29",{"date":77,"type":78},"2026-05-05","ACTUAL",{"date":80,"type":78},"2002-10",{"date":82,"type":65},"2030-01",{"name":5,"class":6},1]