[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652551":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":37,"responsibleParty":52,"collaborators":11,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":11,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":11,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"National University of Singapore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"mushroom powder intervention arm","EXPERIMENTAL",null,[13],"Dietary Supplement: Golden oyster mushroom powder",{"label":15,"type":16,"description":11,"interventionNames":11},"Placebo arm","NO_INTERVENTION",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"DIETARY_SUPPLEMENT","Golden oyster mushroom powder","Participants in the intervention group will consume Pleurotus citrinopileatus mushroom powder daily for 24months, with compliance monitored using electronic diary apps. The powder contains 7.0 mg\u002Fg of ergothioneine (dry weight).",[9],[24],{"name":25,"affiliation":5,"role":26},"Lei FEng","PRINCIPAL_INVESTIGATOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Jiatong Shan","CONTACT","+65 89413228","e1397079@u.nus.edu",{"name":34,"role":30,"phone":35,"phoneExt":11,"email":36},"Kai Xuan Lim","+65 90553343","kaixuan@nus.edu.sg",[38],{"facility":39,"status":40,"city":41,"state":11,"zip":42,"country":41,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Tahir Foundation Building, MD1, Level 12 (12 Science Drive 2)","RECRUITING","Singapore","117549","SG",{"type":45,"coordinates":46},"Point",[47,48],103.85007,1.28967,{"lat":48,"lon":47},[51],{"name":34,"role":30,"phone":35,"phoneExt":11,"email":36},{"type":26,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Feng Lei","Assistant Professor","100652551","study-protocol-the-efficacy-of-mushroom-to-reduce-cognitive-decline-in-at-risk-middle-aged-adults-and-young-olds-living-in-the-community-100652551",false,"NCT07775833","Study Protocol: The Efficacy of Mushroom to Reduce Cognitive Decline in At-Risk Middle-aged Adults and Young-olds Living in the Community","Inclusion Criteria:\n\n* (1) Community-living adult aged 45 years to 80 years, AND\n* (2) Family history of Alzheimer's disease or having subjective cognitive (SCD) defined as \"self-reported memory problems that have been getting worse over the past year.\", AND\n* (3) Consume mushrooms no more than once a week, AND\n* (4) No dementia: CDR global score equal to zero.\n\nExclusion Criteria:\n\n* (1) Any diagnosis of neurological diseases (e.g., epilepsy, stroke) made by a clinician, OR\n* (2) Any diagnosis of psychiatric illnesses (e.g., depressive disorders) made by a clinician, OR\n* (3) Significant sensory or motor impairments, OR\n* (4) Known allergy to mushrooms or a history of serious food allergies, OR\n* (5) Participants with a history of gout, OR\n* (6) Diagnosed with hyperuricemia.",true,"ALL","45 Years","80 Years",{"count":66,"type":67},600,"ESTIMATED","INTERVENTIONAL",[70],"NA","The investigator's objective is to explore the definitive evidence of mushroom on cognitive functions among at-risk middle-aged and young-olds.\n\nThe investigator carefully designed a randomized controlled trial (RCT) to assess the role of mushrooms in promoting cognitive functioning among around 600 middle-aged adults and young-olds.\n\nParticipants were selected based on specific inclusion criteria, such as being community-living adults aged 45-80 years with a family history of dementia or subjective cognitive decline, while consuming mushrooms no more than once a week and having no dementia, along with the exclusion of individuals with neurological or psychiatric disorders and significant sensory or motor impairments. Participants in the intervention group will consume Pleurotus citrinopileatus mushroom powder daily for 24months, with compliance",[73,74],"Dementia","Cognitive Assessment","2026-08-18",{"date":77,"type":78},"2026-08-20","ACTUAL",{"date":80,"type":67},"2026-10",{"date":82,"type":67},"2030-12",{"name":5,"class":6},1]